The R7 RGS protein family: multi-subunit regulators of neuronal G protein signaling
about
GPR158/179 regulate G protein signaling by controlling localization and activity of the RGS7 complexesType 5 G protein beta subunit (Gbeta5) controls the interaction of regulator of G protein signaling 9 (RGS9) with membrane anchorsBehavioral and Genetic Evidence for GIRK Channels in the CNS: Role in Physiology, Pathophysiology, and Drug AddictionRegulators of G-protein signaling in the heart and their potential as therapeutic targets.Photoreceptor signaling: supporting vision across a wide range of light intensities.R7BP complexes with RGS9-2 and RGS7 in the striatum differentially control motor learning and locomotor responses to cocaineLight-induced translocation of RGS9-1 and Gβ5L in mouse rod photoreceptorsG protein beta 5 is targeted to D2-dopamine receptor-containing biochemical compartments and blocks dopamine-dependent receptor internalizationAssociation between regulator of G protein signaling 9-2 and body weightRegulation of GPCR activity, trafficking and localization by GPCR-interacting proteins.The evolution of regulators of G protein signalling proteins as drug targets - 20 years in the making: IUPHAR Review 21.RSBP-1 is a membrane-targeting subunit required by the Galpha(q)-specific but not the Galpha(o)-specific R7 regulator of G protein signaling in Caenorhabditis elegans.Regulator of G protein signaling 6 (RGS6) protein ensures coordination of motor movement by modulating GABAB receptor signaling.Photophobia and abnormally sustained pupil responses in a mouse model of bradyopsia.Membrane anchor R9AP potentiates GTPase-accelerating protein activity of RGS11 x Gbeta5 complex and accelerates inactivation of the mGluR6-G(o) signaling.Association of Rgs7/Gβ5 complexes with Girk channels and GABAB receptors in hippocampal CA1 pyramidal neurons.Proteomic identification of Hsc70 as a mediator of RGS9-2 degradation by in vivo interactome analysis.Nuclear localization of the G protein beta 5/R7-regulator of G protein signaling protein complex is dependent on R7 binding protein.Decreased RGS6 expression is associated with poor prognosis in pancreatic cancer patientsRegulators of G-protein signaling and their Gα substrates: promises and challenges in their use as drug discovery targets.cAMP regulates DEP domain-mediated binding of the guanine nucleotide exchange factor Epac1 to phosphatidic acid at the plasma membraneBrown and white adipose tissues: intrinsic differences in gene expression and response to cold exposure in miceA conserved protein interaction interface on the type 5 G protein beta subunit controls proteolytic stability and activity of R7 family regulator of G protein signaling proteins.Regulator of G protein signaling 6 (RGS6) induces apoptosis via a mitochondrial-dependent pathway not involving its GTPase-activating protein activity.Rgs6 is required for adult maintenance of dopaminergic neurons in the ventral substantia nigra.Gi/o signaling and the palmitoyltransferase DHHC2 regulate palmitate cycling and shuttling of RGS7 family-binding protein.Helix 8 and the i3 loop of the muscarinic M3 receptor are crucial sites for its regulation by the Gβ5-RGS7 complex.Knockout of G protein β5 impairs brain development and causes multiple neurologic abnormalities in mice.Targeted deletion of one or two copies of the G protein β subunit Gβ5 gene has distinct effects on body weight and behavior in mice.Membrane attachment is key to protecting transducin GTPase-activating complex from intracellular proteolysis in photoreceptorsRegulator of G protein signaling 9-2 (RGS9-2) mRNA is up regulated during neuronal differentiation of mouse embryonic stem cells.β-arrestin2 plays permissive roles in the inhibitory activities of RGS9-2 on G protein-coupled receptors by maintaining RGS9-2 in the open conformation.D(2)-Dopamine receptors target regulator of G protein signaling 9-2 to detergent-resistant membrane fractions.Orphan Receptor GPR158 Is an Allosteric Modulator of RGS7 Catalytic Activity with an Essential Role in Dictating Its Expression and Localization in the BrainGβ5-RGS complexes are gatekeepers of hyperactivity involved in control of multiple neurotransmitter systems.Regulators of G protein signaling RGS7 and RGS11 determine the onset of the light response in ON bipolar neurons.Fine Mapping of the Body Fat QTL on Human Chromosome 1q43.Expression of the Gβ5/R7-RGS protein complex in pituitary and pancreatic islet cells.Subcellular localization of regulator of G protein signaling RGS7 complex in neurons and transfected cells.Functional mapping of interacting regions of the photoreceptor phosphodiesterase (PDE6) γ-subunit with PDE6 catalytic dimer, transducin, and regulator of G-protein signaling9-1 (RGS9-1).
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P2860
The R7 RGS protein family: multi-subunit regulators of neuronal G protein signaling
description
2009 nî lūn-bûn
@nan
2009 թուականին հրատարակուած գիտական յօդուած
@hyw
2009 թվականին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
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name
The R7 RGS protein family: multi-subunit regulators of neuronal G protein signaling
@ast
The R7 RGS protein family: multi-subunit regulators of neuronal G protein signaling
@en
The R7 RGS protein family: multi-subunit regulators of neuronal G protein signaling
@nl
type
label
The R7 RGS protein family: multi-subunit regulators of neuronal G protein signaling
@ast
The R7 RGS protein family: multi-subunit regulators of neuronal G protein signaling
@en
The R7 RGS protein family: multi-subunit regulators of neuronal G protein signaling
@nl
prefLabel
The R7 RGS protein family: multi-subunit regulators of neuronal G protein signaling
@ast
The R7 RGS protein family: multi-subunit regulators of neuronal G protein signaling
@en
The R7 RGS protein family: multi-subunit regulators of neuronal G protein signaling
@nl
P2093
P2860
P921
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P1476
The R7 RGS protein family: multi-subunit regulators of neuronal G protein signaling
@en
P2093
Ekaterina Posokhova
Garret R Anderson
Kirill A Martemyanov
P2860
P2888
P3181
P356
10.1007/S12013-009-9052-9
P407
P577
2009-01-01T00:00:00Z
P5875
P6179
1048436418