Cell cycle-dependent colocalization of BARD1 and BRCA1 proteins in discrete nuclear domains
about
Nuclear localization and cell cycle-specific expression of CtIP, a protein that associates with the BRCA1 tumor suppressorNovel alternative splicing and nuclear localization of human RGS12 gene productsNucleophosmin/B23 is a candidate substrate for the BRCA1-BARD1 ubiquitin ligaseBARD1 induces apoptosis by catalysing phosphorylation of p53 by DNA-damage response kinaseBRCA1/BARD1 inhibition of mRNA 3' processing involves targeted degradation of RNA polymerase II.Highlight: BRCA1 and BRCA2 proteins in breast cancerControl of biochemical reactions through supramolecular RING domain self-assembly.Siah-1 N-terminal RING domain is required for proteolysis function, and C-terminal sequences regulate oligomerization and binding to target proteinsBRCA1 and BRCA2 proteins: roles in health and diseaseDegradation of transcription repressor ZBRK1 through the ubiquitin-proteasome pathway relieves repression of Gadd45a upon DNA damageBinding and recognition in the assembly of an active BRCA1/BARD1 ubiquitin-ligase complexStructural Basis of Targeting the Exportin CRM1 in CancerA guide for functional analysis of BRCA1 variants of uncertain significanceThe BRCA1 Breast Cancer Suppressor: Regulation of Transport, Dynamics, and Function at Multiple Subcellular LocationsNuclear-cytoplasmic shuttling of BARD1 contributes to its proapoptotic activity and is regulated by dimerization with BRCA1The RING heterodimer BRCA1-BARD1 is a ubiquitin ligase inactivated by a breast cancer-derived mutationBARD1 induces BRCA1 intranuclear foci formation by increasing RING-dependent BRCA1 nuclear import and inhibiting BRCA1 nuclear exportIdentification of residues required for the interaction of BARD1 with BRCA1Enhancement of BRCA1 E3 ubiquitin ligase activity through direct interaction with the BARD1 proteinIs there more to BARD1 than BRCA1?BRCA1-BARD1 complexes are required for p53Ser-15 phosphorylation and a G1/S arrest following ionizing radiation-induced DNA damageOverexpression of RAD51 occurs in aggressive prostatic cancerHigh RAD51 mRNA expression characterize estrogen receptor-positive/progesteron receptor-negative breast cancer and is associated with patient's outcomeLoss of Bard1, the heterodimeric partner of the Brca1 tumor suppressor, results in early embryonic lethality and chromosomal instabilityBARD1 participates with BRCA1 in homology-directed repair of chromosome breaksChromatin remodeling and activation of chromosomal DNA replication by an acidic transcriptional activation domain from BRCA1.Rapid recruitment of BRCA1 to DNA double-strand breaks is dependent on its association with Ku80The functions of breast cancer susceptibility gene 1 (BRCA1) product and its associated proteins.BRCA1 and BRCA2 in breast cancer.PI 3 kinase related kinases-independent proteolysis of BRCA1 regulates Rad51 recruitment during genotoxic stress in human cells.Structural basis to stabilize the domain motion of BARD1-ARD BRCT by CstF50.Role of the tumor suppressor gene Brca1 in genetic stability and mammary gland tumor formation.Tumor suppressor p53 is required to modulate BRCA1 expression.BRCA1 and cell signaling.DNA polymerase stalling, sister chromatid recombination and the BRCA genes.BRCA1 and prostate cancer.A conditional mouse model for measuring the frequency of homologous recombination events in vivo in the absence of essential genes.Identification and characterization of missense alterations in the BRCA1 associated RING domain (BARD1) gene in breast and ovarian cancerA model for mitotic inheritance of histone lysine methylation.AKT regulates BRCA1 stability in response to hormone signaling.
P2860
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P2860
Cell cycle-dependent colocalization of BARD1 and BRCA1 proteins in discrete nuclear domains
description
1997 nî lūn-bûn
@nan
1997 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
1997 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
1997年の論文
@ja
1997年論文
@yue
1997年論文
@zh-hant
1997年論文
@zh-hk
1997年論文
@zh-mo
1997年論文
@zh-tw
1997年论文
@wuu
name
Cell cycle-dependent colocaliz ...... ns in discrete nuclear domains
@ast
Cell cycle-dependent colocaliz ...... ns in discrete nuclear domains
@en
Cell cycle-dependent colocaliz ...... ns in discrete nuclear domains
@nl
type
label
Cell cycle-dependent colocaliz ...... ns in discrete nuclear domains
@ast
Cell cycle-dependent colocaliz ...... ns in discrete nuclear domains
@en
Cell cycle-dependent colocaliz ...... ns in discrete nuclear domains
@nl
prefLabel
Cell cycle-dependent colocaliz ...... ns in discrete nuclear domains
@ast
Cell cycle-dependent colocaliz ...... ns in discrete nuclear domains
@en
Cell cycle-dependent colocaliz ...... ns in discrete nuclear domains
@nl
P2093
P2860
P356
P1476
Cell cycle-dependent colocaliz ...... ns in discrete nuclear domains
@en
P2093
P2860
P304
12075-12080
P356
10.1073/PNAS.94.22.12075
P407
P577
1997-10-01T00:00:00Z