Reconstructed evolutionary adaptive paths give polymerases accepting reversible terminators for sequencing and SNP detection
about
Beyond directed evolution--semi-rational protein engineering and designExploiting models of molecular evolution to efficiently direct protein engineeringDirected evolution: an evolving and enabling synthetic biology toolDNA polymerases engineered by directed evolution to incorporate non-standard nucleotidesIrreversible inhibition of DNA polymerase β by small-molecule mimics of a DNA lesionUtilizing natural diversity to evolve protein function: applications towards thermostability.Directed evolution of DNA polymerases for next-generation sequencing.Toward more accurate ancestral protein genotype-phenotype reconstructions with the use of species tree-aware gene trees.The history and advances of reversible terminators used in new generations of sequencing technology.AAV ancestral reconstruction library enables selection of broadly infectious viral variants.The Toolbox for Modified Aptamers.Synergistic Effects of an Irreversible DNA Polymerase Inhibitor and DNA Damaging Agents on HeLa Cells.Ancestral protein resurrection and engineering opportunities of the mamba aminergic toxinsConstructing de novo biosynthetic pathways for chemical synthesis inside living cells.Directed polymerase evolution.Expanding the metabolic engineering toolbox with directed evolution.The functional importance of co-evolving residues in proteins.DNA polymerases drive DNA sequencing-by-synthesis technologies: both past and present.Directed evolution 2.0: improving and deciphering enzyme properties.Methods for the directed evolution of proteins.Alternative Watson-Crick Synthetic Genetic Systems.Engineering human PrimPol into an efficient RNA-dependent-DNA primase/polymerase.Fluoride-cleavable, fluorescently labelled reversible terminators: synthesis and use in primer extension.Rapid incorporation kinetics and improved fidelity of a novel class of 3'-OH unblocked reversible terminators.Labeled nucleoside triphosphates with reversibly terminating aminoalkoxyl groups.Design and Discovery of New Combinations of Mutant DNA Polymerases and Modified DNA Substrates.The evolution of substrate discrimination in macrolide antibiotic resistance enzymes.Directed evolution of SIRT6 for improved deacylation and glucose homeostasis maintenance.Single-base mismatch discrimination by T7 exonuclease with target cyclic amplification detection.Protein design: from computer models to artificial intelligence
P2860
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P2860
Reconstructed evolutionary adaptive paths give polymerases accepting reversible terminators for sequencing and SNP detection
description
2010 nî lūn-bûn
@nan
2010 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年学术文章
@wuu
2010年学术文章
@zh-cn
2010年学术文章
@zh-hans
2010年学术文章
@zh-my
2010年学术文章
@zh-sg
2010年學術文章
@yue
name
Reconstructed evolutionary ada ...... r sequencing and SNP detection
@ast
Reconstructed evolutionary ada ...... r sequencing and SNP detection
@en
Reconstructed evolutionary ada ...... r sequencing and SNP detection
@nl
type
label
Reconstructed evolutionary ada ...... r sequencing and SNP detection
@ast
Reconstructed evolutionary ada ...... r sequencing and SNP detection
@en
Reconstructed evolutionary ada ...... r sequencing and SNP detection
@nl
prefLabel
Reconstructed evolutionary ada ...... r sequencing and SNP detection
@ast
Reconstructed evolutionary ada ...... r sequencing and SNP detection
@en
Reconstructed evolutionary ada ...... r sequencing and SNP detection
@nl
P2093
P2860
P356
P1476
Reconstructed evolutionary ada ...... r sequencing and SNP detection
@en
P2093
Daniel Hutter
Eric A Gaucher
Eric A Ortlund
Nicole A Leal
Sridhar Govindarajan
Stephanie A Havemann
P2860
P304
P356
10.1073/PNAS.0908463107
P407
P577
2010-02-02T00:00:00Z