Soluble hemojuvelin is released by proprotein convertase-mediated cleavage at a conserved polybasic RNRR site
about
Hemojuvelin and bone morphogenetic protein (BMP) signaling in iron homeostasisPro-protein convertases control the maturation and processing of the iron-regulatory protein, RGMc/hemojuvelinNeogenin interacts with hemojuvelin through its two membrane-proximal fibronectin type III domainsConserved proximal promoter elements control repulsive guidance molecule c/hemojuvelin (Hfe2) gene transcription in skeletal muscleNeogenin-mediated hemojuvelin shedding occurs after hemojuvelin traffics to the plasma membraneBMP signaling modulates hepcidin expression in zebrafish embryos independent of hemojuvelinMolecular biology, genetics and biochemistry of the repulsive guidance molecule familySelective binding of RGMc/hemojuvelin, a key protein in systemic iron metabolism, to BMP-2 and neogeninSuppression of hepatic hepcidin expression in response to acute iron deprivation is associated with an increase of matriptase-2 proteinIdentification of TMPRSS6 cleavage sites of hemojuvelinRole of matriptase-2 (TMPRSS6) in iron metabolism.Iron Loading and Overloading due to Ineffective Erythropoiesis.Molecular mechanisms of hepcidin regulation: implications for the anemia of CKD.Liver and muscle hemojuvelin are differently glycosylated.Soluble repulsive guidance molecule c/hemojuvelin is a broad spectrum bone morphogenetic protein (BMP) antagonist and inhibits both BMP2- and BMP6-mediated signaling and gene expression.Immunoassay for human serum hemojuvelinMatriptase-2- and proprotein convertase-cleaved forms of hemojuvelin have different roles in the down-regulation of hepcidin expression.Repulsive guidance molecule (RGM) family proteins exhibit differential binding kinetics for bone morphogenetic proteins (BMPs)Novel association to the proprotein convertase PCSK7 gene locus revealed by analysing soluble transferrin receptor (sTfR) levels.Skeletal muscle hemojuvelin is dispensable for systemic iron homeostasis.Regulation of cell surface transferrin receptor-2 by iron-dependent cleavage and release of a soluble form.Impaired hepcidin expression in alpha-1-antitrypsin deficiency associated with iron overload and progressive liver disease.Neogenin interacts with matriptase-2 to facilitate hemojuvelin cleavage.A novel validated enzyme-linked immunosorbent assay to quantify soluble hemojuvelin in mouse serum.The RGM/DRAGON family of BMP co-receptorsIron homeostasis: recently identified proteins provide insight into novel control mechanismsNeogenin Facilitates the Induction of Hepcidin Expression by Hemojuvelin in the Liver.Processing of hemojuvelin requires retrograde trafficking to the Golgi in HepG2 cells.Hemojuvelin-neogenin interaction is required for bone morphogenic protein-4-induced hepcidin expression.Genetics of the first seven proprotein convertase enzymes in health and disease.The liver: conductor of systemic iron balance.The iron cycle in chronic kidney disease (CKD): from genetics and experimental models to CKD patients.The Regulation of Iron Absorption and Homeostasis.Molecular mechanisms of normal iron homeostasis.Control of systemic iron homeostasis by the hemojuvelin-hepcidin axis.Obesity and iron deficiency in chronic kidney disease: the putative role of hepcidin.Repulsive guidance molecules (RGMs) and neogenin in bone morphogenetic protein (BMP) signaling.The role of adipocytes in the modulation of iron metabolism in obesity.Regulation of cellular iron metabolism and its implications in lung cancer progression.The mutual control of iron and erythropoiesis.
P2860
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P2860
Soluble hemojuvelin is released by proprotein convertase-mediated cleavage at a conserved polybasic RNRR site
description
2008 nî lūn-bûn
@nan
2008 թուականին հրատարակուած գիտական յօդուած
@hyw
2008 թվականին հրատարակված գիտական հոդված
@hy
2008年の論文
@ja
2008年学术文章
@wuu
2008年学术文章
@zh-cn
2008年学术文章
@zh-hans
2008年学术文章
@zh-my
2008年学术文章
@zh-sg
2008年學術文章
@yue
name
Soluble hemojuvelin is release ...... conserved polybasic RNRR site
@ast
Soluble hemojuvelin is release ...... conserved polybasic RNRR site
@en
Soluble hemojuvelin is release ...... conserved polybasic RNRR site
@nl
type
label
Soluble hemojuvelin is release ...... conserved polybasic RNRR site
@ast
Soluble hemojuvelin is release ...... conserved polybasic RNRR site
@en
Soluble hemojuvelin is release ...... conserved polybasic RNRR site
@nl
prefLabel
Soluble hemojuvelin is release ...... conserved polybasic RNRR site
@ast
Soluble hemojuvelin is release ...... conserved polybasic RNRR site
@en
Soluble hemojuvelin is release ...... conserved polybasic RNRR site
@nl
P2093
P2860
P1476
Soluble hemojuvelin is release ...... conserved polybasic RNRR site
@en
P2093
Dharma R Thapa
Elizabeta Nemeth
Julia B Goodnough
Victoria Gabayan
P2860
P304
P356
10.1016/J.BCMD.2007.06.023
P407
P50
P577
2008-01-01T00:00:00Z