The differentiation of human T(H)-17 cells requires transforming growth factor-beta and induction of the nuclear receptor RORgammat - Wikidata - awgldk - TriplyDB

The differentiation of human T(H)-17 cells requires transforming growth factor-beta and induction of the nuclear receptor RORgammat

The differentiation of human T(H)-17 cells requires transforming growth factor-beta and induction of the nuclear receptor RORgammat

http://www.wikidata.org/entity/Q24648890

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An integrative computational systems biology approach identifies differentially regulated dynamic transcriptome signatures which drive the initiation of human T helper cell differentiation The environment of regulatory T cell biology: cytokines, metabolites, and the microbiome T helper 17 cell heterogeneity and pathogenicity in autoimmune disease Secukinumab for rheumatology: development and its potential place in therapy Targeting Th17 Cells with Small Molecules and Small Interference RNA Advances in T Helper 17 Cell Biology: Pathogenic Role and Potential Therapy in Multiple Sclerosis Autoimmune Liver Disease Post-Liver Transplantation: A Summary and Proposed Areas for Future Research Maintenance of Immune Homeostasis through ILC/T Cell Interactions Regulation of IL-17 in autoimmune diseases by transcriptional factors and microRNAs Inflammatory cytokines in systemic lupus erythematosus Regulation of human helper T cell subset differentiation by cytokines An immunology primer for computational modelers ROR nuclear receptors: structures, related diseases, and drug discovery Pouring fuel on the fire: Th17 cells, the environment, and autoimmunity Graft rejection - endogenous or allogeneic?IL-17+Foxp3+ T cells: an intermediate differentiation stage between Th17 cells and regulatory T cells Diversity of IL-17-producing T lymphocytes Immune Components of Liver Damage Associated with Connective Tissue Diseases Th22 cells in allergic disease Correlations between psoriasis and inflammatory bowel diseases Putting together the psoriasis puzzle: an update on developing targeted therapies Deoxynivalenol as a new factor in the persistence of intestinal inflammatory diseases: an emerging hypothesis through possible modulation of Th17-mediated response Structural Basis of Digoxin That Antagonizes ROR t Receptor Activity and Suppresses Th17 Cell Differentiation and Interleukin (IL)-17 Production The IL-23-IL-17 immune axis: from mechanisms to therapeutic testing Birdshot retinochoroidopathy Mast cells and neutrophils release IL-17 through extracellular trap formation in psoriasis The IL-20 subfamily of cytokines--from host defence to tissue homeostasis Sterol metabolism controls T(H)17 differentiation by generating endogenous RORγ agonists T(H)17 cells promote microbial killing and innate immune sensing of DNA via interleukin 26 A human natural killer cell subset provides an innate source of IL-22 for mucosal immunity The IL-17 pathway as a major therapeutic target in autoimmune diseases Regulation of the psoriatic chemokine CCL20 by E3 ligases Trim32 and Piasy in keratinocytes Development of a Topical Treatment for Psoriasis Targeting RORγ: From Bench to Skin A validated regulatory network for Th17 cell specification Cytokine responses in birds challenged with the human food-borne pathogen Campylobacter jejuni implies a Th17 response Src kinases are required for a balanced production of IL-12/IL-23 in human dendritic cells activated by Toll-like receptor agonists Circulating immune cells in multiple sclerosis.The role of peroxisome proliferator-activated receptor γ in immune responses to enteroaggregative Escherichia coli infection.Tumor-like stem cells derived from human keloid are governed by the inflammatory niche driven by IL-17/IL-6 axis.The changes of Th17 cells and the related cytokines in the progression of human colorectal cancers.

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The differentiation of human T(H)-17 cells requires transforming growth factor-beta and induction of the nuclear receptor RORgammat

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The differentiation of human T ...... the nuclear receptor RORgammat

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Dan R Littman

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Derya Unutmaz

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Nicolas Manel

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P2860

Stimulation of the intracellular bacterial sensor NOD2 programs dendritic cells to promote interleukin-17 production in human memory T cells

A receptor for the heterodimeric cytokine IL-23 is composed of IL-12Rbeta1 and a novel cytokine receptor subunit, IL-23R

IRAK (Pelle) family member IRAK-2 and MyD88 as proximal mediators of IL-1 signaling

TGF-beta-induced Foxp3 inhibits T(H)17 cell differentiation by antagonizing RORgammat function

Differential activation of acute phase response factor/STAT3 and STAT1 via the cytoplasmic domain of the interleukin 6 signal transducer gp130. I. Definition of a novel phosphotyrosine motif mediating STAT1 activation

IL-21 is produced by Th17 cells and drives IL-17 production in a STAT3-dependent manner

T cell interleukin-17 induces stromal cells to produce proinflammatory and hematopoietic cytokines

IL-23 receptor (IL-23R) gene protects against pediatric Crohn's disease

Interleukin-17 production in central nervous system-infiltrating T cells and glial cells is associated with active disease in multiple sclerosis

Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells

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10.1038/NI.1610

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18454151

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2597394

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