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Predicting new molecular targets for known drugs

Predicting new molecular targets for known drugs

http://www.wikidata.org/entity/Q24649687

about

The application of the open pharmacological concepts triple store (Open PHACTS) to support drug discovery research The ketamine analogue methoxetamine and 3- and 4-methoxy analogues of phencyclidine are high affinity and selective ligands for the glutamate NMDA receptor Genome-scale screening of drug-target associations relevant to Ki using a chemogenomics approach Evolution of minimal specificity and promiscuity in steroid hormone receptors Chapter 7: Pharmacogenomics BitterDB: a database of bitter compounds ChemProt: a disease chemical biology database Multiple receptors contribute to the behavioral effects of indoleamine hallucinogens.Chemical informatics uncovers a new role for moexipril as a novel inhibitor of cAMP phosphodiesterase-4 (PDE4)Computational approaches in target identification and drug discovery Drug Repurposing Is a New Opportunity for Developing Drugs against Neuropsychiatric Disorders Systems Pharmacology in Small Molecular Drug Discovery Integrating Multiscale Modeling with Drug Effects for Cancer Treatment Leveraging big data to transform target selection and drug discovery Psychedelics and Immunomodulation: Novel Approaches and Therapeutic Opportunities Network-based approaches in drug discovery and early development Effects of opioids on immunologic parameters that are relevant to anti-tumour immune potential in patients with cancer: a systematic literature review DREADDs: novel tools for drug discovery and development Linked clinical trials--the development of new clinical learning studies in Parkinson's disease using screening of multiple prospective new treatments Computational methods in drug discovery Cholinergic modulation by opioid receptor ligands: potential application to Alzheimer's disease Translational bioinformatics: linking the molecular world to the clinical world A survey on the computational approaches to identify drug targets in the postgenomic era Structure and dynamics of molecular networks: a novel paradigm of drug discovery: a comprehensive review Recent advances in the neuropsychopharmacology of serotonergic hallucinogens Metabolomics and systems pharmacology: why and how to model the human metabolic network for drug discovery In silico molecular comparisons of C. elegans and mammalian pharmacology identify distinct targets that regulate feeding Complementarity Between a Docking and a High-Throughput Screen in Discovering New Cruzain Inhibitors Inhibition of Antibiotic-Resistant Staphylococcus aureus by the Broad-Spectrum Dihydrofolate Reductase Inhibitor RAB1 Prediction of the Carcinogenic Potential of Human Pharmaceuticals Using Repeated Dose Toxicity Data and Their Pharmacological Properties.DRABAL: novel method to mine large high-throughput screening assays using Bayesian active learning A multi-label approach to target prediction taking ligand promiscuity into account Accurate and efficient target prediction using a potency-sensitive influence-relevance voter Improving chemical similarity ensemble approach in target prediction BioTriangle: a web-accessible platform for generating various molecular representations for chemicals, proteins, DNAs/RNAs and their interactions Target prediction utilising negative bioactivity data covering large chemical space Leveraging 3D chemical similarity, target and phenotypic data in the identification of drug-protein and drug-adverse effect associations DASPfind: new efficient method to predict drug–target interactions Epigenetic polypharmacology: from combination therapy to multitargeted drugs Genome-wide significant loci: how important are they? Systems genetics to understand heritability of coronary artery disease and other common complex disorders

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Predicting new molecular targets for known drugs

http://www.wikidata.org/entity/Q24649687

description

2009 nî lūn-bûn

@nan

2009 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած

@hyw

2009 թվականի նոյեմբերին հրատարակված գիտական հոդված

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2009年の論文

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2009年論文

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2009年論文

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2009年論文

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2009年論文

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2009年論文

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2009年论文

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name

Predicting new molecular targets for known drugs

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Predicting new molecular targets for known drugs

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Predicting new molecular targets for known drugs

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Predicting new molecular targets for known drugs

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Predicting new molecular targets for known drugs

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Predicting new molecular targets for known drugs

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Predicting new molecular targets for known drugs

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Brian K Shoichet

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Roberto C Matos

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Ryan Whaley

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Cloning, characterization, and chromosomal localization of a human 5-HT6 serotonin receptor

The hallucinogen N,N-dimethyltryptamine (DMT) is an endogenous sigma-1 receptor regulator

When the endogenous hallucinogenic trace amine N,N-dimethyltryptamine meets the sigma-1 receptor.

Basic local alignment search tool

A class of selective antibacterials derived from a protein kinase inhibitor pharmacophore

ZINC--a free database of commercially available compounds for virtual screening

The effect of antihistaminic preparations on the binding of labelled mepyramine, ketanserin and quinuclidinyl benzilate in the rat brain

Magic shotguns versus magic bullets: selectively non-selective drugs for mood disorders and schizophrenia

Drugs and valvular heart disease

WAY 100635 produces discriminative stimulus effects in rats mediated by dopamine D(4) receptor activation

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10.1038/NATURE08506

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Michael J Keiser

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