Female lethality and apoptosis of spermatocytes in mice lacking the UBR2 ubiquitin ligase of the N-end rule pathway - Wikidata - awgldk - TriplyDB

Female lethality and apoptosis of spermatocytes in mice lacking the UBR2 ubiquitin ligase of the N-end rule pathway

Female lethality and apoptosis of spermatocytes in mice lacking the UBR2 ubiquitin ligase of the N-end rule pathway

http://www.wikidata.org/entity/Q24649866

about

A family of mammalian E3 ubiquitin ligases that contain the UBR box motif and recognize N-degrons.The N-end rule pathway Discovery of cellular regulation by protein degradation Synthetic heterovalent inhibitors targeting recognition E3 components of the N-end rule pathway Structural basis of substrate recognition and specificity in the N-end rule pathway Rpn4 is a physiological substrate of the Ubr2 ubiquitin ligase.Amino acids induce peptide uptake via accelerated degradation of CUP9, the transcriptional repressor of the PTR2 peptide transporter.Deficiency of UBR1, a ubiquitin ligase of the N-end rule pathway, causes pancreatic dysfunction, malformations and mental retardation (Johanson-Blizzard syndrome)The ubiquitin ligase Ubr2, a recognition E3 component of the N-end rule pathway, stabilizes Tex19.1 during spermatogenesis Mutation in mouse hei10, an e3 ubiquitin ligase, disrupts meiotic crossing over Biochemical and genetic studies of UBR3, a ubiquitin ligase with a function in olfactory and other sensory systems UBR2 mediates transcriptional silencing during spermatogenesis via histone ubiquitination The substrate recognition domains of the N-end rule pathway.The UBR-box and its relationship to binuclear RING-like treble clef zinc fingers Ablation of arginylation in the mouse N-end rule pathway: loss of fat, higher metabolic rate, damaged spermatogenesis, and neurological perturbations.PINK1 is degraded through the N-end rule pathway Sent to destroy: the ubiquitin proteasome system regulates cell signaling and protein quality control in cardiovascular development and disease.Ubiquitin ligases of the N-end rule pathway: assessment of mutations in UBR1 that cause the Johanson-Blizzard syndrome RGS4 and RGS5 are in vivo substrates of the N-end rule pathway The N-end rule pathway and regulation by proteolysis UBR2 of the N-end rule pathway is required for chromosome stability via histone ubiquitylation in spermatocytes and somatic cells.Crystal structure of human protein N-terminal glutamine amidohydrolase, an initial component of the N-end rule pathway.Aminoacyl-transferases and the N-end rule pathway of prokaryotic/eukaryotic specificity in a human pathogen Ubr3 E3 ligase regulates apoptosis by controlling the activity of DIAP1 in Drosophila.Impact of the N-terminal amino acid on targeted protein degradation.Impaired neurogenesis and cardiovascular development in mice lacking the E3 ubiquitin ligases UBR1 and UBR2 of the N-end rule pathway.Expression and biochemical characterization of the human enzyme N-terminal asparagine amidohydrolase.Poly(ADP-ribose) polymerase-2 contributes to the fidelity of male meiosis I and spermiogenesis Alternative ubiquitin activation/conjugation cascades interact with N-end rule ubiquitin ligases to control degradation of RGS proteins.Single nucleotide polymorphism in the UBR2 gene may be a genetic risk factor for Japanese patients with azoospermia by meiotic arrest.Meiotic functions of RAD18.Heteromorphic sex chromosomes: navigating meiosis without a homologous partner.Mice lacking the USP2 deubiquitinating enzyme have severe male subfertility associated with defects in fertilization and sperm motility.Amino-terminal arginylation targets endoplasmic reticulum chaperone BiP for autophagy through p62 binding Cardiac Nav 1.5 is modulated by ubiquitin protein ligase E3 component n-recognin UBR3 and 6.Characterization of arginylation branch of N-end rule pathway in G-protein-mediated proliferation and signaling of cardiomyocytes The N-end rule pathway counteracts cell death by destroying proapoptotic protein fragments Pharmacological Modulation of the N-End Rule Pathway and Its Therapeutic Implications.Listeriolysin O secreted by Listeria monocytogenes into the host cell cytosol is degraded by the N-end rule pathway.UBR box N-recognin-4 (UBR4), an N-recognin of the N-end rule pathway, and its role in yolk sac vascular development and autophagy

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P2860

Female lethality and apoptosis of spermatocytes in mice lacking the UBR2 ubiquitin ligase of the N-end rule pathway

http://www.wikidata.org/entity/Q24649866

description

2003 nî lūn-bûn

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2003 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած

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2003 թվականի նոյեմբերին հրատարակված գիտական հոդված

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2003年の論文

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2003年論文

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2003年論文

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2003年論文

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2003年論文

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2003年論文

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2003年论文

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Female lethality and apoptosis ...... gase of the N-end rule pathway

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Female lethality and apoptosis ...... gase of the N-end rule pathway

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Female lethality and apoptosis ...... gase of the N-end rule pathway

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Female lethality and apoptosis ...... gase of the N-end rule pathway

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Female lethality and apoptosis ...... gase of the N-end rule pathway

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Female lethality and apoptosis ...... gase of the N-end rule pathway

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Female lethality and apoptosis ...... gase of the N-end rule pathway

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Female lethality and apoptosis ...... gase of the N-end rule pathway

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Female lethality and apoptosis ...... gase of the N-end rule pathway

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MCB.23.22.8255-8271.2003

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Molecular and Cellular Biology

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Female lethality and apoptosis ...... gase of the N-end rule pathway

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Alexander Varshavsky

http://www.w3.org/2001/XMLSchema#string

Ilia V Davydov

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Jai Wha Seo

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Jee Young An

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Jun Sheng

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Takafumi Tasaki

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Yong Tae Kwon

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Youming Xie

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Zanxian Xia

http://www.w3.org/2001/XMLSchema#string

P2860

Cohesin cleavage by separase required for anaphase and cytokinesis in human cells

The N-end rule: functions, mysteries, uses

The mouse and human genes encoding the recognition component of the N-end rule pathway

Mechanisms underlying ubiquitination

Peptides accelerate their uptake by activating a ubiquitin-dependent proteolytic pathway.

The E2-E3 interaction in the N-end rule pathway: the RING-H2 finger of E3 is required for the synthesis of multiubiquitin chain.

Degradation of HIV-1 integrase by the N-end rule pathway

Meiotic cohesin REC8 marks the axial elements of rat synaptonemal complexes before cohesins SMC1beta and SMC3

Loss of HR6B ubiquitin-conjugating activity results in damaged synaptonemal complex structure and increased crossing-over frequency during the male meiotic prophase.

Female germ cell aneuploidy and embryo death in mice lacking the meiosis-specific protein SCP3

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8255-71

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4514869

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10.1128/MCB.23.22.8255-8271.2003

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22

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2003-11-01T00:00:00Z

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14585983

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apoptotic process

Ubiquitin protein ligase E3 component n-recognin 1

Ubiquitin protein ligase E3 component n-recognin 2

Ubiquitin-conjugating enzyme E2B

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