Ribonucleases as novel chemotherapeutics : the ranpirnase example
about
Barnase as a new therapeutic agent triggering apoptosis in human cancer cellsFunctional and structural analyses of N-acylsulfonamide-linked dinucleoside inhibitors of RNase AOnconase and amphinase, the antitumor ribonucleases from Rana pipiens oocytesComparative functional analysis of ribonuclease 1 homologs: Molecular insights into evolving vertebrate physiology.Arginine residues are more effective than lysine residues in eliciting the cellular uptake of onconase.Modern Technologies for Creating Synthetic Antibodies for Clinical application.Onconase responsive genes in human mesothelioma cells: implications for an RNA damaging therapeutic agent.Replacing Mn(2+) with Co(2+) in human arginase i enhances cytotoxicity toward l-arginine auxotrophic cancer cell lines.Cellular uptake of ribonuclease A relies on anionic glycans.The cytotoxic ribonuclease onconase targets RNA interference (siRNA).Antitumor activity of ribonuclease multimers created by site-specific covalent tethering.Ribonuclease/angiogenin inhibitor 1 regulates stress-induced subcellular localization of angiogenin to control growth and survival.MicroRNA drop in the bloodstream and microRNA boost in the tumour caused by treatment with ribonuclease A leads to an attenuation of tumour malignancy.Fluorogenic label to quantify the cytosolic delivery of macromolecules.Fluorogenic probe for constitutive cellular endocytosisCytostatic and cytotoxic properties of Amphinase: a novel cytotoxic ribonuclease from Rana pipiens oocytes.Human ribonuclease with a pendant poly(ethylene glycol) inhibits tumor growth in mice.Ribonuclease binase inhibits primary tumor growth and metastases via apoptosis induction in tumor cells.Evasion of ribonuclease inhibitor as a determinant of ribonuclease cytotoxicityRanpirnase and its potential for the treatment of unresectable malignant mesotheliomaRibonucleases as potential modalities in anticancer therapyStability and folding of amphibian ribonuclease A superfamily members in comparison with mammalian homologues.Site-specific PEGylation endows a mammalian ribonuclease with antitumor activity.Rational design and evaluation of mammalian ribonuclease cytotoxinsOnconase mediated NFKβ downregulation in malignant pleural mesothelioma.Potentiation of ribonuclease cytotoxicity by a poly(amidoamine) dendrimer.An efficient synthetic approach to 6,5'-(S)- and 6,5'-(R)-cyclouridine.Onconase cytotoxicity relies on the distribution of its positive charge.Mechanism of ribonuclease A endocytosis: analogies to cell-penetrating peptides.Remarkable enhancement of cytotoxicity of onconase and cepharanthine when used in combination on various tumor cell lines.RNA-Pt adducts following cisplatin treatment of Saccharomyces cerevisiae.Design and characterization of an HIV-specific ribonuclease zymogen.Site-specific folate conjugation to a cytotoxic protein.Humane anesthesia and pain management in amphibian limb surgery of Rana pipiens.Interaction of onconase with the human ribonuclease inhibitor protein.Contribution of electrostatics to the binding of pancreatic-type ribonucleases to membranes.Silencing an inhibitor unleashes a cytotoxic enzyme.The systemic tumor response to RNase A treatment affects the expression of genes involved in maintaining cell malignancy.Onconase downregulates microRNA expression through targeting microRNA precursors.Two variables dominating the retention of intact proteins under gradient elution with simultaneous ultrafast high-resolution separation by hydrophobic interaction chromatography.
P2860
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P2860
Ribonucleases as novel chemotherapeutics : the ranpirnase example
description
2008 nî lūn-bûn
@nan
2008 թուականին հրատարակուած գիտական յօդուած
@hyw
2008 թվականին հրատարակված գիտական հոդված
@hy
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
name
Ribonucleases as novel chemotherapeutics : the ranpirnase example
@ast
Ribonucleases as novel chemotherapeutics : the ranpirnase example
@en
Ribonucleases as novel chemotherapeutics : the ranpirnase example
@nl
type
label
Ribonucleases as novel chemotherapeutics : the ranpirnase example
@ast
Ribonucleases as novel chemotherapeutics : the ranpirnase example
@en
Ribonucleases as novel chemotherapeutics : the ranpirnase example
@nl
prefLabel
Ribonucleases as novel chemotherapeutics : the ranpirnase example
@ast
Ribonucleases as novel chemotherapeutics : the ranpirnase example
@en
Ribonucleases as novel chemotherapeutics : the ranpirnase example
@nl
P2860
P1433
P1476
Ribonucleases as novel chemotherapeutics : the ranpirnase example
@en
P2093
J Eugene Lee
P2860
P356
10.2165/00063030-200822010-00006
P407
P577
2008-01-01T00:00:00Z
P5875
P6179
1010524008