Role of sigma-1 receptor C-terminal segment in inositol 1,4,5-trisphosphate receptor activation: constitutive enhancement of calcium signaling in MCF-7 tumor cells
about
Sigma receptors: potential targets for a new class of antidepressant drugCrystal structure of the human σ1 receptorThe sigma-1 receptor is enriched in postsynaptic sites of C-terminals in mouse motoneurons. An anatomical and behavioral studyActivation of the Sigma-1 receptor by haloperidol metabolites facilitates brain-derived neurotrophic factor secretion from human astrogliaCharacterization of the human sigma-1 receptor chaperone domain structure and binding immunoglobulin protein (BiP) interactionsRegulation of sigma-1 receptors and endoplasmic reticulum chaperones in the brain of methamphetamine self-administering ratsThe oligomeric states of the purified sigma-1 receptor are stabilized by ligands.Inositol 1,4,5-trisphosphate-induced Ca2+ signalling is involved in estradiol-induced breast cancer epithelial cell growth.Inhibition of sigma-1 receptor reduces N-methyl-D-aspartate induced neuronal injury in methamphetamine-exposed and -naive hippocampi.Identification of the PGRMC1 protein complex as the putative sigma-2 receptor binding site.Photoaffinity labeling of the sigma-1 receptor with N-[3-(4-nitrophenyl)propyl]-N-dodecylamine: evidence of receptor dimers.Sigma receptor 1 modulates endoplasmic reticulum stress in retinal neurons.Involvement of sigma-1 receptors in the antidepressant-like effects of dextromethorphan.Late-onset inner retinal dysfunction in mice lacking sigma receptor 1 (σR1).The sigma1 receptor interacts with N-alkyl amines and endogenous sphingolipids.Role of the Sigma-1 receptor in Amyotrophic Lateral Sclerosis (ALS)The sigma-1 receptors are present in monomeric and oligomeric forms in living cells in the presence and absence of ligandsThe sigma-1 receptor protects against cellular oxidative stress and activates antioxidant response elements.Expression of a truncated form of the endoplasmic reticulum chaperone protein, σ1 receptor, promotes mitochondrial energy depletion and apoptosis.The sigma-1 receptor mediates the beneficial effects of pridopidine in a mouse model of Huntington diseaseSynthesis and characterization of N,N-dialkyl and N-alkyl-N-aralkyl fenpropimorph-derived compounds as high affinity ligands for sigma receptors.Sigma1 receptors inhibit store-operated Ca2+ entry by attenuating coupling of STIM1 to Orai1Modulation of the endoplasmic reticulum-mitochondria interface in Alzheimer's disease and related models.Sigma-1 receptor alters the kinetics of Kv1.3 voltage gated potassium channels but not the sensitivity to receptor ligands.The pharmacology of sigma-1 receptors.ER-Mitochondria Crosstalk during Cerebral Ischemia: Molecular Chaperones and ER-Mitochondrial Calcium Transfer.Selective sigma-1 receptor antagonists for the treatment of pain.Involvement of ion channels and transporters in carcinoma angiogenesis and metastasis.Sigma-1 Receptors and Neurodegenerative Diseases: Towards a Hypothesis of Sigma-1 Receptors as Amplifiers of Neurodegeneration and Neuroprotection.Loss-of-function mutations in the SIGMAR1 gene cause distal hereditary motor neuropathy by impairing ER-mitochondria tethering and Ca2+ signalling.New neurogenic lipoic-based hybrids as innovative Alzheimer's drugs with σ-1 agonism and β-secretase inhibition.Sigma 1 Receptor and Ion Channel Dynamics in Cancer.Targeting Nanocarriers with Anisamide: Fact or Artifact?Peeking into Sigma-1 Receptor Functions Through the Retina.2-Aminopyridine derivatives as potential σ(2) receptor antagonists.The SigmaR1 chaperone drives breast and colorectal cancer cell migration by tuning SK3-dependent Ca2+ homeostasis.Mechanisms of activation of nucleus accumbens neurons by cocaine via sigma-1 receptor-inositol 1,4,5-trisphosphate-transient receptor potential canonical channel pathways.Sigmar1 regulates endoplasmic reticulum stress-induced C/EBP-homologous protein expression in cardiomyocytes.Solution NMR studies reveal the location of the second transmembrane domain of the human sigma-1 receptor.Synthesis and pharmacological evaluation of like- and unlike-configured tetrahydro-2-benzazepines with the α-substituted benzyl moiety in the 5-position.
P2860
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P2860
Role of sigma-1 receptor C-terminal segment in inositol 1,4,5-trisphosphate receptor activation: constitutive enhancement of calcium signaling in MCF-7 tumor cells
description
2008 nî lūn-bûn
@nan
2008 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2008 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
name
Role of sigma-1 receptor C-ter ...... signaling in MCF-7 tumor cells
@ast
Role of sigma-1 receptor C-ter ...... signaling in MCF-7 tumor cells
@en
Role of sigma-1 receptor C-ter ...... signaling in MCF-7 tumor cells
@nl
type
label
Role of sigma-1 receptor C-ter ...... signaling in MCF-7 tumor cells
@ast
Role of sigma-1 receptor C-ter ...... signaling in MCF-7 tumor cells
@en
Role of sigma-1 receptor C-ter ...... signaling in MCF-7 tumor cells
@nl
prefLabel
Role of sigma-1 receptor C-ter ...... signaling in MCF-7 tumor cells
@ast
Role of sigma-1 receptor C-ter ...... signaling in MCF-7 tumor cells
@en
Role of sigma-1 receptor C-ter ...... signaling in MCF-7 tumor cells
@nl
P2860
P3181
P356
P1476
Role of sigma-1 receptor C-ter ...... signaling in MCF-7 tumor cells
@en
P2093
Wayne D Bowen
Zhiping Wu
P2860
P304
P3181
P356
10.1074/JBC.M802099200
P407
P577
2008-10-17T00:00:00Z