Identification of human and mouse p19, a novel CDK4 and CDK6 inhibitor with homology to p16ink4
about
The p16(INK4a) tumour suppressor protein inhibits alphavbeta3 integrin-mediated cell spreading on vitronectin by blocking PKC-dependent localization of alphavbeta3 to focal contacts.INK4 cell cycle inhibitors direct transcriptional inactivation of NF-kappaBIsolation and characterization of p19INK4d, a p16-related inhibitor specific to CDK6 and CDK4CAK-independent activation of CDK6 by a viral cyclinTransforming growth factor beta stabilizes p15INK4B protein, increases p15INK4B-cdk4 complexes, and inhibits cyclin D1-cdk4 association in human mammary epithelial cellsId2 specifically alters regulation of the cell cycle by tumor suppressor proteinsNovel INK4 proteins, p19 and p18, are specific inhibitors of the cyclin D-dependent kinases CDK4 and CDK6Structure-based design of p18INK4c proteins with increased thermodynamic stability and cell cycle inhibitory activityStructure of the cyclin-dependent kinase inhibitor p19Ink4dCrystal structure of the CDK4/6 inhibitory protein p18INK4c provides insights into ankyrin-like repeat structure/function and tumor-derived p16INK4 mutationsGenetic and biochemical interactions among Yar1, Ltv1 and Rps3 define novel links between environmental stress and ribosome biogenesis in Saccharomyces cerevisiae.An essential function of a phosphoinositide-specific phospholipase C is relieved by inhibition of a cyclin-dependent protein kinase in the yeast Saccharomyces cerevisiaeLack of p19INK4d in human testicular germ-cell tumours contrasts with high expression during normal spermatogenesisThe INK4 family of cell cycle inhibitors in cancerp57Kip2 regulates actin dynamics by binding and translocating LIM-kinase 1 to the nucleusBiochemical characterization of p16INK4- and p18-containing complexes in human cell linesAn important role of CDK inhibitor p18(INK4c) in modulating antigen receptor-mediated T cell proliferationRedistribution of the CDK inhibitor p27 between different cyclin.CDK complexes in the mouse fibroblast cell cycle and in cells arrested with lovastatin or ultraviolet irradiationTbx5-hedgehog molecular networks are essential in the second heart field for atrial septationFunctional redundancy of the Nur77 and Nor-1 orphan steroid receptors in T-cell apoptosis9-Aminoacridine inhibition of HIV-1 Tat dependent transcription.Overexpression of cell cycle regulator CDCA3 promotes oral cancer progression by enhancing cell proliferation with prevention of G1 phase arrest.p27kip1: a multifunctional cyclin-dependent kinase inhibitor with prognostic significance in human cancers.Prognostic implications of expression of the cell cycle inhibitor protein p27Kip1.Human T-cell leukemia virus type 1 Tax and cell cycle progression: role of cyclin D-cdk and p110Rb.c-Myc regulates cyclin D-Cdk4 and -Cdk6 activity but affects cell cycle progression at multiple independent pointsCoupled transcriptional and translational control of cyclin-dependent kinase inhibitor p18INK4c expression during myogenesis.Cell cycle checkpoints and their inactivation in human cancer.Molecular mechanisms of oxidative stress-induced carcinogenesis: from epidemiology to oxygenomics.p53-independent inhibition of proliferation and p21(WAF1/Cip1)-modulated induction of cell death by the antioxidants N-acetylcysteine and vitamin E.Iron and carcinogenesis: from Fenton reaction to target genes.A murine tumor progression model for pancreatic cancer recapitulating the genetic alterations of the human diseaseAlterations in signal transduction pathways implicated in tumour progression during multistage mouse skin carcinogenesis.Cell-cycle control of plasma cell differentiation and tumorigenesis.Incomplete folding upon binding mediates Cdk4/cyclin D complex activation by tyrosine phosphorylation of inhibitor p27 protein.Genetic evidence for functional dependency of p18Ink4c on Cdk4.Cyclin-dependent kinase inhibitor p27KIP1 in lymphoid tissue: p27KIP1 expression is inversely proportional to the proliferative indexAnti-p19 antibody treatment exacerbates lyme arthritis and enhances borreliacidal activity.Expression of p27(kip) and other cell cycle regulators in malignant peripheral nerve sheath tumors and neurofibromas: the emerging role of p27(kip) in malignant transformation of neurofibromas.Deletions of the INK4A gene occur in malignant peripheral nerve sheath tumors but not in neurofibromas
P2860
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P2860
Identification of human and mouse p19, a novel CDK4 and CDK6 inhibitor with homology to p16ink4
description
1995 nî lūn-bûn
@nan
1995 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
1995 թվականի մայիսին հրատարակված գիտական հոդված
@hy
1995年の論文
@ja
1995年論文
@yue
1995年論文
@zh-hant
1995年論文
@zh-hk
1995年論文
@zh-mo
1995年論文
@zh-tw
1995年论文
@wuu
name
Identification of human and mo ...... bitor with homology to p16ink4
@ast
Identification of human and mo ...... bitor with homology to p16ink4
@en
Identification of human and mo ...... bitor with homology to p16ink4
@nl
type
label
Identification of human and mo ...... bitor with homology to p16ink4
@ast
Identification of human and mo ...... bitor with homology to p16ink4
@en
Identification of human and mo ...... bitor with homology to p16ink4
@nl
prefLabel
Identification of human and mo ...... bitor with homology to p16ink4
@ast
Identification of human and mo ...... bitor with homology to p16ink4
@en
Identification of human and mo ...... bitor with homology to p16ink4
@nl
P2093
P2860
P356
P1476
Identification of human and mo ...... bitor with homology to p16ink4
@en
P2093
P2860
P304
P356
10.1128/MCB.15.5.2682
P407
P577
1995-05-01T00:00:00Z