Ubc4/5 and c-Cbl continue to ubiquitinate EGF receptor after internalization to facilitate polyubiquitination and degradation
about
Threshold-controlled ubiquitination of the EGFR directs receptor fateVHS domains of ESCRT-0 cooperate in high-avidity binding to polyubiquitinated cargoSCAMP3 negatively regulates epidermal growth factor receptor degradation and promotes receptor recycling.Protein tyrosine kinase regulation by ubiquitination: critical roles of Cbl-family ubiquitin ligasesUEV-1 is an ubiquitin-conjugating enzyme variant that regulates glutamate receptor trafficking in C. elegans neuronsCbl controls EGFR fate by regulating early endosome fusion.Lysine 63-linked polyubiquitination of the dopamine transporter requires WW3 and WW4 domains of Nedd4-2 and UBE2D ubiquitin-conjugating enzymes.The phosphatase and tensin homolog regulates epidermal growth factor receptor (EGFR) inhibitor response by targeting EGFR for degradationRoles of E3 ubiquitin ligases in cell adhesion and migration.The von Hippel-Lindau tumor suppressor protein promotes c-Cbl-independent poly-ubiquitylation and degradation of the activated EGFR.Heterozygous germline mutations in the CBL tumor-suppressor gene cause a Noonan syndrome-like phenotype.A novel TIP30 protein complex regulates EGF receptor signaling and endocytic degradation.Impaired degradation followed by enhanced recycling of epidermal growth factor receptor caused by hypo-phosphorylation of tyrosine 1045 in RBE cells.Alteration of EGFR spatiotemporal dynamics suppresses signal transduction.Ubiquitination-dependent regulation of signaling receptors in cancer.Nexus of signaling and endocytosis in oncogenesis driven by non-small cell lung cancer-associated epidermal growth factor receptor mutants.Macromolecular juggling by ubiquitylation enzymes.Endocytosis and intracellular trafficking of ErbBs.ESCRT-0 marks an APPL1-independent transit route for EGFR between the cell surface and the EEA1-positive early endosome.Cytoplasmic retention of a nucleocytoplasmic protein TBC1D3 by microtubule network is required for enhanced EGFR signalingThe signaling and transformation potency of the overexpressed HER2 protein is dependent on the normally-expressed EGFR.Molecular mechanisms of ubiquitin-dependent membrane trafficYmer acts as a multifunctional regulator in nuclear factor-κB and Fas signaling pathways.CIN85 phosphorylation is essential for EGFR ubiquitination and sorting into multivesicular bodies.Forskolin stimulation promotes urea transporter UT-A1 ubiquitination, endocytosis, and degradation in MDCK cells.CCN2 inhibits lung cancer metastasis through promoting DAPK-dependent anoikis and inducing EGFR degradation.RIN1 orchestrates the activation of RAB5 GTPases and ABL tyrosine kinases to determine the fate of EGFR.Lysine 63-linked polyubiquitination is required for EGF receptor degradation.Epidermal growth factor receptor phosphorylation sites Ser991 and Tyr998 are implicated in the regulation of receptor endocytosis and phosphorylations at Ser1039 and Thr1041.Membrane protein targeting to the MVB/lysosome.Degradation of activated protein kinases by ubiquitination.Spatio-temporal regulation of EGFR signaling by the Eps15 homology domain-containing protein 3 (EHD3).Cbl-family proteins as regulators of cytoskeleton-dependent phenomena.Phosphatidylinositol 3-phosphate, a lipid that regulates membrane dynamics, protein sorting and cell signalling.Regulation of EGFR signal transduction by analogue-to-digital conversion in endosomes.Ubiquitin conjugase UBCH8 targets active FMS-like tyrosine kinase 3 for proteasomal degradation.VAV2 regulates epidermal growth factor receptor endocytosis and degradation.Endocytosis of Ubiquitylation-Deficient EGFR Mutants via Clathrin-Coated Pits is Mediated by Ubiquitylation.The Roles of VHL-Dependent Ubiquitination in Signaling and Cancer.Contribution of lysine 11-linked ubiquitination to MIR2-mediated major histocompatibility complex class I internalization
P2860
Q24296784-40E42978-E4FF-4F44-9DB4-A99BECF04000Q24299091-354EDCF1-9FE2-4C55-AE3C-099F589691B9Q24657896-45CFD62E-D9DC-4FB4-9269-A9D7B446081AQ26852269-41DC6072-8A1E-4FAE-AA6C-1694F3EE5DA4Q27315936-D37671AF-BB96-462D-B202-6D6C07951974Q30492938-A44531C0-88BC-4CB7-8AE1-D0FA6DBD8567Q33748196-2144F02A-C582-4426-B90E-10C832526D0DQ33778905-8240715A-608D-4033-9BD0-3C22F004C2C5Q33781079-B0097108-1104-4297-A588-B7B5CD9F9CA9Q34031245-AC712892-E4A3-4079-896B-073F6D407030Q34050931-F9BB21A1-005F-4322-9BB2-87E36EA59530Q34160054-D82F0879-5DC7-4FFD-AD39-CE878166B31DQ34271518-72027BE7-84BD-49FE-8A15-F141256B8151Q34326437-2667AD08-ED5C-46C8-AC73-21C1E2A35EE8Q34365210-0A5AB217-C675-4C65-81AB-0CD1B20C3AFAQ34657670-47345D2A-F69D-4401-8C6B-25C29D0B6C66Q34782977-22B675C5-6486-4340-8AE6-397D278F6DC9Q34827744-B76D1EDC-C4AC-4A3C-960C-6B852F1B4CE7Q35081689-F5B9AAB4-DCCB-4B23-A0ED-30DA0C582C8CQ35142815-0C4FD257-7291-4812-B34E-53797369B5D5Q35491037-ECC1AF8F-513E-438E-9EB6-AEC05D0BBEC6Q35738601-566BB851-6E28-4F4E-95AD-493BEAEB63E4Q36071725-695226F5-1574-4AAE-B115-0545F1C4183BQ36234483-7EF763D1-FDCD-4F0C-9560-FA0D31FC526EQ36455845-8A93B172-D34D-4418-B599-4C3B3E3703F5Q36603116-12ABBB69-0845-49D4-9AB0-1FF59C49DA0EQ36619492-6AD3DFA9-A1C9-4FAD-8E9C-B450ADEEB6F3Q37203860-5FCC8782-1A54-41E4-811A-E39D7E099571Q37343076-602B3520-7B20-40F0-A64A-4323569F2889Q37401247-ADAC1088-7CF9-4299-A7B3-C28F593C856BQ37419861-23EA5C6C-F96D-4091-9EBE-8132529E94DCQ37694775-6061227C-4CCD-46C9-9825-D3086E284291Q38112644-E96CF11B-1AF7-492E-83A2-11C536896129Q38123773-DD1334E2-C5B2-434B-9A84-3CA8766C5462Q39206639-8D6B74B5-F8A0-43D1-9393-FE6916577AEEQ39699250-EBFDA839-42ED-4229-BEF6-28A3ADDA2EE8Q39742296-4D631285-F3DB-4AFA-8DFB-C56D2583F994Q41832305-6BAB4A2E-3CAD-429F-AC2F-F32399FF5E83Q41911531-E69B8635-42BD-4F77-89D2-E7224837F88AQ42014050-5DB3523A-990C-482D-A384-FB8C0D0E48B9
P2860
Ubc4/5 and c-Cbl continue to ubiquitinate EGF receptor after internalization to facilitate polyubiquitination and degradation
description
2008 nî lūn-bûn
@nan
2008 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2008 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
name
Ubc4/5 and c-Cbl continue to u ...... ubiquitination and degradation
@ast
Ubc4/5 and c-Cbl continue to u ...... ubiquitination and degradation
@en
Ubc4/5 and c-Cbl continue to u ...... ubiquitination and degradation
@nl
type
label
Ubc4/5 and c-Cbl continue to u ...... ubiquitination and degradation
@ast
Ubc4/5 and c-Cbl continue to u ...... ubiquitination and degradation
@en
Ubc4/5 and c-Cbl continue to u ...... ubiquitination and degradation
@nl
prefLabel
Ubc4/5 and c-Cbl continue to u ...... ubiquitination and degradation
@ast
Ubc4/5 and c-Cbl continue to u ...... ubiquitination and degradation
@en
Ubc4/5 and c-Cbl continue to u ...... ubiquitination and degradation
@nl
P2860
P356
P1476
Ubc4/5 and c-Cbl continue to u ...... ubiquitination and degradation
@en
P2093
Kyohei Umebayashi
P2860
P304
P356
10.1091/MBC.E07-10-0988
P407
P577
2008-08-01T00:00:00Z