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The histamine H3 receptor: an attractive target for the treatment of cognitive disorders

The histamine H3 receptor: an attractive target for the treatment of cognitive disorders

http://www.wikidata.org/entity/Q24654788

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Attention-modulating effects of cognitive enhancers Drug Design for CNS Diseases: Polypharmacological Profiling of Compounds Using Cheminformatic, 3D-QSAR and Virtual Screening Methodologies Multiple Targeting Approaches on Histamine H3 Receptor Antagonists International Union of Basic and Clinical Pharmacology. XCVIII. Histamine Receptors Histamine H3 receptors and its antagonism as a novel mechanism for antipsychotic effect: a current preclinical & clinical perspective S 38093, a histamine H3 antagonist/inverse agonist, promotes hippocampal neurogenesis and improves context discrimination task in aged mice.Bioactive marine drugs and marine biomaterials for brain diseases The H3 antagonist ABT-288 is tolerated at significantly higher exposures in subjects with schizophrenia than in healthy volunteers A neurodevelopmental framework for the development of interventions for children with fetal alcohol spectrum disorders Pharmacological treatment of schizophrenia: a critical review of the pharmacology and clinical effects of current and future therapeutic agents.A randomized trial of the efficacy and safety of the H3 antagonist ABT-288 in cognitive impairment associated with schizophrenia.Differential effects of acute and repeat dosing with the H3 antagonist GSK189254 on the sleep-wake cycle and narcoleptic episodes in Ox-/- mice.Alzheimer's disease and age-related memory decline (preclinical)Histamine-2 receptor antagonist use and incident dementia in an older cohort Loss of Melanopsin Photoreception and Antagonism of the Histamine H3 Receptor by Ciproxifan Inhibit Light-Induced Sleep in Mice.Effects of methimepip and JNJ-5207852 in Wistar rats exposed to an open-field with and without object and in Balb/c mice exposed to a radial-arm maze Blockade of the brain histamine H3 receptor by JNJ-39220675: preclinical PET studies with [¹¹C]GSK189254 in anesthetized baboon.Enhanced histaminergic neurotransmission and sleep-wake alterations, a study in histamine H3-receptor knock-out mice.Safety, tolerability and pharmacokinetics of the histamine H3 receptor antagonist, ABT-288, in healthy young adults and elderly volunteers.Histamine-induced itch and its relationship with pain.Effects of a novel cognition-enhancing agent on fetal ethanol-induced learning deficits.Histamine-HisCl1 receptor axis regulates wake-promoting signals in Drosophila melanogaster Potential enhancing effects of histamine H₁ agonism/H₃ antagonism on working memory assessed by performance and bold response in healthy volunteers Characterization of histamine H3 receptors in Alzheimer's Disease brain and amyloid over-expressing TASTPM mice Use of the H3 receptor antagonist radioligand [3H]-A-349821 to reveal in vivo receptor occupancy of cognition enhancing H3 receptor antagonists Differential effects of the histamine H(3) receptor agonist methimepip on dentate granule cell excitability, paired-pulse plasticity and long-term potentiation in prenatal alcohol-exposed rats.Ligand autoradiographical quantification of histamine H3 receptor in human dementia with Lewy bodies.Molecular and biochemical pharmacology of the histamine H4 receptor.The Obesity-Impulsivity Axis: Potential Metabolic Interventions in Chronic Psychiatric Patients.Recent progress in neuroactive marine natural products.Current therapeutic targets for the treatment of Alzheimer's disease.Recent advances in histamine H3 receptor antagonists/inverse agonists.Can small molecules provide truly effective enhancement of cognition? Current achievements and future directions.Histamine pharmacology and new CNS drug targets.Clinical utility of neuroprotective agents in neurodegenerative diseases: current status of drug development for Alzheimer's, Parkinson's and Huntington's diseases, and amyotrophic lateral sclerosis.Histamine H3 receptor antagonists in relation to epilepsy and neurodegeneration: a systemic consideration of recent progress and perspectives.The histaminergic network in the brain: basic organization and role in disease.Procognitive properties of drugs with single and multitargeting H3 receptor antagonist activities.Synthesis, biological evaluation, and computational studies of Tri- and tetracyclic nitrogen-bridgehead compounds as potent dual-acting AChE inhibitors and hH3 receptor antagonists.Recent advances in acetylcholinesterase Inhibitors and Reactivators: an update on the patent literature (2012-2015).

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The histamine H3 receptor: an attractive target for the treatment of cognitive disorders

http://www.wikidata.org/entity/Q24654788

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The histamine H3 receptor: an attractive target for the treatment of cognitive disorders

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The histamine H3 receptor: an attractive target for the treatment of cognitive disorders

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The histamine H3 receptor: an attractive target for the treatment of cognitive disorders

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The histamine H3 receptor: an attractive target for the treatment of cognitive disorders

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The histamine H3 receptor: an attractive target for the treatment of cognitive disorders

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The histamine H3 receptor: an attractive target for the treatment of cognitive disorders

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British Journal of Pharmacology

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The histamine H3 receptor: an attractive target for the treatment of cognitive disorders

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J D Brioni

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K E Browman

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M D Cowart

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M Strakhova

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R S Bitner

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Cloning and functional expression of the human histamine H3 receptor

Genomic organization and characterization of splice variants of the human histamine H3 receptor

Acute wake-promoting actions of JNJ-5207852, a novel, diamine-based H3 antagonist

Neurochemical and behavioral effects of ciproxifan, a potent histamine H3-receptor antagonist

The histamine H3 receptor as a novel therapeutic target for cognitive and sleep disorders

Pharmacological properties of ABT-239 [4-(2-{2-[(2R)-2-Methylpyrrolidinyl]ethyl}-benzofuran-5-yl)benzonitrile]: II. Neurophysiological characterization and broad preclinical efficacy in cognition and schizophrenia of a potent and selective histamine

Pharmacological properties of ABT-239 [4-(2-{2-[(2R)-2-Methylpyrrolidinyl]ethyl}-benzofuran-5-yl)benzonitrile]: I. Potent and selective histamine H3 receptor antagonist with drug-like properties

The challenge of drug discovery of a GPCR target: analysis of preclinical pharmacology of histamine H3 antagonists/inverse agonists

4-(2-[2-(2(R)-methylpyrrolidin-1-yl)ethyl]benzofuran-5-yl)benzonitrile and related 2-aminoethylbenzofuran H3 receptor antagonists potently enhance cognition and attention

Cloning of rat histamine H(3) receptor reveals distinct species pharmacological profiles

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889114

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10.1038/BJP.2008.147

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6

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154

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5381398

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18469850

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2483387

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