LXR regulates cholesterol uptake through Idol-dependent ubiquitination of the LDL receptor
about
Annexin A2 is a natural extrahepatic inhibitor of the PCSK9-induced LDL receptor degradationFibroblast growth factor-21 (FGF21) regulates low-density lipoprotein receptor (LDLR) levels in cells via the E3-ubiquitin ligase Mylip/Idol and the Canopy2 (Cnpy2)/Mylip-interacting saposin-like protein (Msap)The IDOL-UBE2D complex mediates sterol-dependent degradation of the LDL receptorBiological, clinical and population relevance of 95 loci for blood lipidsRegulated accumulation of desmosterol integrates macrophage lipid metabolism and inflammatory responsesHypercholesterolemia, low density lipoprotein receptor and proprotein convertase subtilisin/kexin-type 9The Regulation of Reverse Cholesterol Transport and Cellular Cholesterol Homeostasis by MicroRNAsRole of gut microbiota in the modulation of atherosclerosis-associated immune responseMitochondrial function and regulation of macrophage sterol metabolism and inflammatory responsesA new model of reverse cholesterol transport: enTICEing strategies to stimulate intestinal cholesterol excretionFrom evolution to revolution: miRNAs as pharmacological targets for modulating cholesterol efflux and reverse cholesterol transportUbiquitin ligases in cholesterol metabolismMechanisms and genetic determinants regulating sterol absorption, circulating LDL levels, and sterol elimination: implications for classification and disease riskLiver X receptor and peroxisome proliferator-activated receptor as integrators of lipid homeostasis and immunityFeedback regulation of cholesterol uptake by the LXR-IDOL-LDLR axisA new framework for reverse cholesterol transport: non-biliary contributions to reverse cholesterol transport.Liver X receptors at the intersection of lipid metabolism and atherogenesisSpatial distribution of the pathways of cholesterol homeostasis in human retinaFeedback modulation of cholesterol metabolism by the lipid-responsive non-coding RNA LeXisActivation of Smurf E3 ligase promoted by smoothened regulates hedgehog signaling through targeting patched turnoverPiperine Induces Hepatic Low-Density Lipoprotein Receptor Expression through Proteolytic Activation of Sterol Regulatory Element-Binding ProteinsGenetics and beyond--the transcriptome of human monocytes and disease susceptibilityCCC- and WASH-mediated endosomal sorting of LDLR is required for normal clearance of circulating LDLSEC24A deficiency lowers plasma cholesterol through reduced PCSK9 secretion.Association between familial hypobetalipoproteinemia and the risk of diabetes. Is this the other side of the cholesterol-diabetes connection? A systematic review of literature.Liver X Receptors Link Lipid Metabolism and Inflammation.Liver X Receptor Agonist TO901317 Attenuates Paraquat-Induced Acute Lung Injury through Inhibition of NF-κB and JNK/p38 MAPK Signal Pathways.Nuclear receptors as drug targets for metabolic disease.Mitotic down-regulation of p190RhoGAP is required for the successful completion of cytokinesisIDOL stimulates clathrin-independent endocytosis and multivesicular body-mediated lysosomal degradation of the low-density lipoprotein receptor.Lipid metabolism emerges as a promising target for malignant glioma therapy.Identification of novel biomarker and therapeutic target candidates for acute intracerebral hemorrhage by quantitative plasma proteomics.A mouse tissue transcription factor atlasCommentary: the year in nuclear receptor control of metabolismMeeting report: nuclear receptors: transcription factors and drug targets connecting basic research with translational medicine.The macrophage LBP gene is an LXR target that promotes macrophage survival and atherosclerosis.Sent to destroy: the ubiquitin proteasome system regulates cell signaling and protein quality control in cardiovascular development and disease.Regulation of hepatic gene expression by saturated fatty acids.An LXR-Cholesterol Axis Creates a Metabolic Co-Dependency for Brain CancersmTORC2 in the center of cancer metabolic reprogramming
P2860
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P2860
LXR regulates cholesterol uptake through Idol-dependent ubiquitination of the LDL receptor
description
2009 nî lūn-bûn
@nan
2009 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
name
LXR regulates cholesterol upta ...... uitination of the LDL receptor
@ast
LXR regulates cholesterol upta ...... uitination of the LDL receptor
@en
LXR regulates cholesterol upta ...... uitination of the LDL receptor
@nl
type
label
LXR regulates cholesterol upta ...... uitination of the LDL receptor
@ast
LXR regulates cholesterol upta ...... uitination of the LDL receptor
@en
LXR regulates cholesterol upta ...... uitination of the LDL receptor
@nl
prefLabel
LXR regulates cholesterol upta ...... uitination of the LDL receptor
@ast
LXR regulates cholesterol upta ...... uitination of the LDL receptor
@en
LXR regulates cholesterol upta ...... uitination of the LDL receptor
@nl
P2093
P2860
P3181
P356
P1433
P1476
LXR regulates cholesterol upta ...... uitination of the LDL receptor
@en
P2093
Cynthia Hong
Noam Zelcer
Rima Boyadjian
P2860
P3181
P356
10.1126/SCIENCE.1168974
P407
P577
2009-07-03T00:00:00Z