A new central scaffold for metastasis: parsing HEF1/Cas-L/NEDD9
about
NEDD9 and BCAR1 negatively regulate E-cadherin membrane localization, and promote E-cadherin degradationDcas supports cell polarization and cell-cell adhesion complexes in developmentA precisely regulated gene expression cassette potently modulates metastasis and survival in multiple solid cancersNEDD9 stabilizes focal adhesions, increases binding to the extra-cellular matrix and differentially effects 2D versus 3D cell migrationThe proximal signaling network of the BCR-ABL1 oncogene shows a modular organizationProinvasion metastasis drivers in early-stage melanoma are oncogenes.NEDD9 promotes oncogenic signaling in mammary tumor development.NEDD9/Arf6-dependent endocytic trafficking of matrix metalloproteinase 14: a novel mechanism for blocking mesenchymal cell invasion and metastasis of breast cancer.Prometastatic NEDD9 Regulates Individual Cell Migration via Caveolin-1-Dependent Trafficking of Integrins.High expression of HEF1 predicts a poorer prognosis of hepatocellular carcinoma: A retrospective study.Preclinical and clinical studies of the NEDD9 scaffold protein in cancer and other diseasesOverexpression of Nedd9 is a prognostic marker of human gastric cancerCAS proteins in health and disease: an updateA novel Cas family member, HEPL, regulates FAK and cell spreading.NEDD9, a novel target of miR-145, increases the invasiveness of glioblastomaNSP-CAS Protein Complexes: Emerging Signaling Modules in CancerRegulation of invasive behavior by vascular endothelial growth factor is HEF1-dependentA requirement for Nedd9 in luminal progenitor cells prior to mammary tumorigenesis in MMTV-HER2/ErbB2 miceHEF1 promotes epithelial mesenchymal transition and bone invasion in prostate cancer under the regulation of microRNA-145NEDD9 promotes lung cancer metastasis through epithelial-mesenchymal transitionNEDD9 depletion leads to MMP14 inactivation by TIMP2 and prevents invasion and metastasisActin polymerization-dependent activation of Cas-L promotes immunological synapse stabilityDissecting carboxypeptidase E: properties, functions and pathophysiological roles in disease.High expression of HEF1 is associated with poor prognosis in urinary bladder carcinoma.The WW-HECT protein Smurf2 interacts with the Docking Protein NEDD9/HEF1 for Aurora A activation.Src kinase determines the dynamic exchange of the docking protein NEDD9 (neural precursor cell expressed developmentally down-regulated gene 9) at focal adhesions.Enhanced genetic instability and dasatinib sensitivity in mammary tumor cells lacking NEDD9Bioinformatic approaches to augment study of epithelial-to-mesenchymal transition in lung cancerOverexpression and cytoplasmic accumulation of Hepl is associated with clinicopathological parameters and poor prognosis in non-small cell lung cancer.Cyclin A2 and its associated kinase activity are required for optimal induction of progesterone receptor target genes in breast cancer cellsAdaptors for disorders of the brain? The cancer signaling proteins NEDD9, CASS4, and PTK2B in Alzheimer's disease.MicroRNA-145: a potent tumour suppressor that regulates multiple cellular pathways.ITF2 is a target of CXCR4 in MDA-MB-231 breast cancer cells and is associated with reduced survival in estrogen receptor-negative breast cancerAn N-terminal truncated carboxypeptidase E splice isoform induces tumor growth and is a biomarker for predicting future metastasis in human cancers.Tyrosine Y189 in the substrate domain of the adhesion docking protein NEDD9 is conserved with p130Cas Y253 and regulates NEDD9-mediated migration and focal adhesion dynamics.TP53 transcription factor for the NEDD9/HEF1/Cas-L gene: potential targets in Non-Small Cell Lung Cancer treatment.Prostaglandins in cancer cell adhesion, migration, and invasionCalmodulin activation of Aurora-A kinase (AURKA) is required during ciliary disassembly and in mitosisOccupy tissue: the movement in cancer metastasis.Aurora kinase A mediates epithelial ovarian cancer cell migration and adhesion
P2860
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P2860
A new central scaffold for metastasis: parsing HEF1/Cas-L/NEDD9
description
2007 nî lūn-bûn
@nan
2007 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2007 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
name
A new central scaffold for metastasis: parsing HEF1/Cas-L/NEDD9
@ast
A new central scaffold for metastasis: parsing HEF1/Cas-L/NEDD9
@en
A new central scaffold for metastasis: parsing HEF1/Cas-L/NEDD9
@nl
type
label
A new central scaffold for metastasis: parsing HEF1/Cas-L/NEDD9
@ast
A new central scaffold for metastasis: parsing HEF1/Cas-L/NEDD9
@en
A new central scaffold for metastasis: parsing HEF1/Cas-L/NEDD9
@nl
prefLabel
A new central scaffold for metastasis: parsing HEF1/Cas-L/NEDD9
@ast
A new central scaffold for metastasis: parsing HEF1/Cas-L/NEDD9
@en
A new central scaffold for metastasis: parsing HEF1/Cas-L/NEDD9
@nl
P2093
P2860
P3181
P1433
P1476
A new central scaffold for metastasis: parsing HEF1/Cas-L/NEDD9
@en
P2093
Erica A Golemis
Geraldine M O'Neill
Ilya G Serebriiskii
Sachiko Seo
Stuart R Lessin
P2860
P304
P3181
P356
10.1158/0008-5472.CAN-07-1328
P407
P577
2007-10-01T00:00:00Z