The structural basis of arrestin-mediated regulation of G-protein-coupled receptors
about
Arrestins: ubiquitous regulators of cellular signaling pathwaysβ-Arrestin-1 mediates the TCR-triggered re-routing of distal receptors to the immunological synapse by a PKC-mediated mechanismG-protein betagamma-complex is crucial for efficient signal amplification in visionAllostery at G protein-coupled receptor homo- and heteromers: uncharted pharmacological landscapesTranslocation of arrestin induced by human A(3) adenosine receptor ligands in an engineered cell line: comparison with G protein-dependent pathwaysThe A(2A)-adenosine receptor: a GPCR with unique features?Function, structure and therapeutic potential of complement C5a receptorsNovel Molecular Approaches in Heart Failure: Seven Trans-Membrane Receptors Signaling in the Heart and Circulating Blood LeukocytesAnalyzing the roles of multi-functional proteins in cells: The case of arrestins and GRKsDiversity and modularity of G protein-coupled receptor structuresStructure of Vps26B and mapping of its interaction with the retromer protein complexStructure of an Arrestin2-Clathrin Complex Reveals a Novel Clathrin Binding Domain That Modulates Receptor TraffickingCrystal Structure of Arrestin-3 Reveals the Basis of the Difference in Receptor Binding Between Two Non-visual SubtypesStructure of active β-arrestin-1 bound to a G-protein-coupled receptor phosphopeptideThe structural basis for the negative regulation of thioredoxin by thioredoxin-interacting proteinStructure of the N-terminal domain of human thioredoxin-interacting proteinA dopamine D2 receptor mutant capable of G protein-mediated signaling but deficient in arrestin bindingHow genetic errors in GPCRs affect their function: Possible therapeutic strategiesOn the origins of arrestin and rhodopsinBiPS, a photocleavable, isotopically coded, fluorescent cross-linker for structural proteomics.Sex differences in the activity of signalling pathways and expression of G-protein-coupled receptor kinases in the neonatal ventral hippocampal lesion model of schizophrenia.Simulations of biased agonists in the β(2) adrenergic receptor with accelerated molecular dynamics.Fluorescence correlation spectroscopy, combined with bimolecular fluorescence complementation, reveals the effects of β-arrestin complexes and endocytic targeting on the membrane mobility of neuropeptide Y receptorsGRK3 suppresses L-DOPA-induced dyskinesia in the rat model of Parkinson's disease via its RGS homology domainOpposing effects of inositol hexakisphosphate on rod arrestin and arrestin2 self-association.Mapping binding sites for the PDE4D5 cAMP-specific phosphodiesterase to the N- and C-domains of beta-arrestin using spot-immobilized peptide arraysMolecular assembly of rhodopsin with G protein-coupled receptor kinases.Phosphorylation of protease-activated receptor-2 differentially regulates desensitization and internalization.Agonist-selective signaling of G protein-coupled receptor: mechanisms and implicationsRhodopsin TM6 can interact with two separate and distinct sites on arrestin: evidence for structural plasticity and multiple docking modes in arrestin-rhodopsin bindingBimolecular fluorescence complementation: lighting up seven transmembrane domain receptor signalling networksG protein-coupled receptor sorting to endosomes and lysosomes.Signal transduction by protease-activated receptorsSeven transmembrane receptors as shapeshifting proteins: the impact of allosteric modulation and functional selectivity on new drug discovery.Beyond desensitization: physiological relevance of arrestin-dependent signaling.Beta-arrestin 2 is required for B1 receptor-dependent post-translational activation of inducible nitric oxide synthase.Identification of receptor binding-induced conformational changes in non-visual arrestins.The effect of arrestin conformation on the recruitment of c-Raf1, MEK1, and ERK1/2 activationSpeed, adaptation, and stability of the response to light in cone photoreceptors: the functional role of Ca-dependent modulation of ligand sensitivity in cGMP-gated ion channelsImportance of regions outside the cytoplasmic tail of G-protein-coupled receptors for phosphorylation and dephosphorylation.
P2860
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P2860
The structural basis of arrestin-mediated regulation of G-protein-coupled receptors
description
2006 nî lūn-bûn
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2006 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2006 թվականի հունիսին հրատարակված գիտական հոդված
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2006年の論文
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2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
name
The structural basis of arrestin-mediated regulation of G-protein-coupled receptors
@ast
The structural basis of arrestin-mediated regulation of G-protein-coupled receptors
@en
The structural basis of arrestin-mediated regulation of G-protein-coupled receptors
@nl
type
label
The structural basis of arrestin-mediated regulation of G-protein-coupled receptors
@ast
The structural basis of arrestin-mediated regulation of G-protein-coupled receptors
@en
The structural basis of arrestin-mediated regulation of G-protein-coupled receptors
@nl
prefLabel
The structural basis of arrestin-mediated regulation of G-protein-coupled receptors
@ast
The structural basis of arrestin-mediated regulation of G-protein-coupled receptors
@en
The structural basis of arrestin-mediated regulation of G-protein-coupled receptors
@nl
P2860
P3181
P1476
The structural basis of arrestin-mediated regulation of G-protein-coupled receptors
@en
P2093
Eugenia V Gurevich
Vsevolod V Gurevich
P2860
P304
P3181
P356
10.1016/J.PHARMTHERA.2005.09.008
P407
P577
2006-06-01T00:00:00Z