Biological background of pediatric medulloblastoma and ependymoma: a review from a translational research perspective - Wikidata - awgldk - TriplyDB

Biological background of pediatric medulloblastoma and ependymoma: a review from a translational research perspective

Biological background of pediatric medulloblastoma and ependymoma: a review from a translational research perspective

http://www.wikidata.org/entity/Q24658389

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The Similarities and Differences between Intracranial and Spinal Ependymomas : A Review from a Genetic Research Perspective Targeting the Hedgehog Pathway in Pediatric Medulloblastoma Molecular genetics of ependymoma Combined Analysis of SNP Array Data Identifies Novel CNV Candidates and Pathways in Ependymoma and Mesothelioma Protein kinase A regulatory subunit distribution in medulloblastoma.NOTCH ligands JAG1 and JAG2 as critical pro-survival factors in childhood medulloblastoma.Fluorescence Lifetime Imaging Microscopy, a Novel Diagnostic Tool for Metastatic Cell Detection in the Cerebrospinal Fluid of Children with Medulloblastoma Ependymoma stem cells are highly sensitive to temozolomide in vitro and in orthotopic models.MicroRNA-31 suppresses medulloblastoma cell growth by inhibiting DNA replication through minichromosome maintenance 2 Mutation and expression analysis in medulloblastoma yields prognostic variants and a putative mechanism of disease for i17q tumors.Establishment and characterization of clinically relevant models of ependymoma: a true challenge for targeted therapy Integration of Network Biology and Imaging to Study Cancer Phenotypes and Responses.MethPed: a DNA methylation classifier tool for the identification of pediatric brain tumor subtypes.Na,K-ATPase β1-subunit is a target of sonic hedgehog signaling and enhances medulloblastoma tumorigenicity.Pharmacological activation of the p53 pathway by nutlin-3 exerts anti-tumoral effects in medulloblastomas An interferon response gene expression signature is activated in a subset of medulloblastomas Pediatric cancer epigenome and the influence of folate A statin-regulated microRNA represses human c-Myc expression and function.Biologically targeted therapeutics in pediatric brain tumors.Epigenetic changes in pediatric solid tumors: promising new targets.Signaling pathway and molecular subgroups of medulloblastoma.Enhanced inhibition of clonogenic survival of human medulloblastoma cells by multimodal treatment with ionizing irradiation, epigenetic modifiers, and differentiation-inducing drugs REST is a novel prognostic factor and therapeutic target for medulloblastoma New approaches to pharmacotherapy of tumors of the nervous system during childhood and adolescence.Epigenetic silencing of miRNA-9 is associated with HES1 oncogenic activity and poor prognosis of medulloblastoma.Cancer stem cell genomics: the quest for early markers of malignant progression.Histology and molecular pathology of pediatric brain tumors.Treatment of posterior fossa tumors in children.Pediatric Ependymoma: A Proteomics Perspective.Understanding the cancer stem cell.Targets for therapy in ependymoma.Medulloblastoma: progress over time.Toward a systems-level understanding of the Hedgehog signaling pathway: defining the complex, robust, and fragile.A contemporary review of molecular candidates for the development and treatment of childhood medulloblastoma.Medulloblastoma and ependymoma cells display increased levels of 5-carboxylcytosine and elevated TET1 expression.The ubiquitin-proteasome system and chromosome 17 in cerebellar granule cells and medulloblastoma subgroups.Medulloblastoma initiation and spread: Where neurodevelopment, microenvironment and cancer cross pathways.MiR-22 is frequently downregulated in medulloblastomas and inhibits cell proliferation via the novel target PAPST1.Anticancer activity of tolfenamic acid in medulloblastoma: a preclinical study.Inhibitory effects of epigenetic modulators and differentiation inducers on human medulloblastoma cell lines.

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Biological background of pediatric medulloblastoma and ependymoma: a review from a translational research perspective

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P2860

Medulloblastoma outcome is adversely associated with overexpression of EEF1D, RPL30, and RPS20 on the long arm of chromosome 8

Characterization of a naturally occurring ErbB4 isoform that does not bind or activate phosphatidyl inositol 3-kinase

Genomic amplification of orthodenticle homologue 2 in medulloblastomas

Identification of a novel c-Myc protein interactor, JPO2, with transforming activity in medulloblastoma cells

Identification of c-MYC as a target of the APC pathway

Constitutional mutations of the hSNF5/INI1 gene predispose to a variety of cancers

Deregulated expression of PAX5 in medulloblastoma

Differential expression and prognostic significance of SOX genes in pediatric medulloblastoma and ependymoma identified by microarray analysis

Molecular genetic analysis of ependymal tumors. NF2 mutations and chromosome 22q loss occur preferentially in intramedullary spinal ependymomas

Notch pathway molecules are essential for the maintenance, but not the generation, of mammalian neural stem cells

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