A positive feedback loop between the p53 and Lats2 tumor suppressors prevents tetraploidization - Wikidata - awgldk - TriplyDB

A positive feedback loop between the p53 and Lats2 tumor suppressors prevents tetraploidization

A positive feedback loop between the p53 and Lats2 tumor suppressors prevents tetraploidization

http://www.wikidata.org/entity/Q24669694

about

The histone H2B-specific ubiquitin ligase RNF20/hBRE1 acts as a putative tumor suppressor through selective regulation of gene expression A newly identified Pirh2 substrate SCYL1-BP1 can bind to MDM2 and accelerate MDM2 self-ubiquitination Mdm2 regulates p53 mRNA translation through inhibitory interactions with ribosomal protein L26 The MST/Hippo Pathway and Cell Death: A Non-Canonical Affair Antiproliferative Fate of the Tetraploid Formed after Mitotic Slippage and Its Promotion; A Novel Target for Cancer Therapy Based on Microtubule Poisons Centrosomes, chromosome instability (CIN) and aneuploidy Inhibition of Chk1 kills tetraploid tumor cells through a p53-dependent pathway Alteration of TEAD1 expression levels confers apoptotic resistance through the transcriptional up-regulation of Livin Merlin, a "magic" linker between extracellular cues and intracellular signaling pathways that regulate cell motility, proliferation, and survival Cell fusion induced by ERVWE1 or measles virus causes cellular senescence Efficient genetic method for establishing Drosophila cell lines unlocks the potential to create lines of specific genotypes Genome-wide impact of a recently expanded microRNA cluster in mouse A latent pro-survival function for the mir-290-295 cluster in mouse embryonic stem cells Mutant p53 Protein and the Hippo Transducers YAP and TAZ: A Critical Oncogenic Node in Human Cancers.A RASSF1A polymorphism restricts p53/p73 activation and associates with poor survival and accelerated age of onset of soft tissue sarcoma.Multipolar mitosis of tetraploid cells: inhibition by p53 and dependency on Mos.Failure of cell cleavage induces senescence in tetraploid primary cells.A limited role for p53 in modulating the immediate phenotype of Apc loss in the intestine.Characterization of the p53 response to oncogene-induced senescence.LATS2 is de-methylated and overexpressed in nasopharyngeal carcinoma and predicts poor prognosis.p53 suppresses structural chromosome instability after mitotic arrest in human cells.Yes-associated protein (YAP) modulates oncogenic features and radiation sensitivity in endometrial cancer Uncoupling of the Hippo and Rho pathways allows megakaryocytes to escape the tetraploid checkpoint.Stability of the LATS2 tumor suppressor gene is regulated by tristetraprolin p53 dependent centrosome clustering prevents multipolar mitosis in tetraploid cells MicroRNAs, genomic instability and cancer.Angiomotin family proteins are novel activators of the LATS2 kinase tumor suppressor.Identification of osteosarcoma driver genes by integrative analysis of copy number and gene expression data.The Lats2 tumor suppressor augments p53-mediated apoptosis by promoting the nuclear proapoptotic function of ASPP1 p53-dependent regulation of autophagy protein LC3 supports cancer cell survival under prolonged starvation.LATS2 suppresses oncogenic Wnt signaling by disrupting β-catenin/BCL9 interaction.YAP, TAZ, and Yorkie: a conserved family of signal-responsive transcriptional coregulators in animal development and human disease.p53: guardian of ploidy Illicit survival of cancer cells during polyploidization and depolyploidization.Helicobacter pylori interferes with an embryonic stem cell micro RNA cluster to block cell cycle progression.Aberrant large tumor suppressor 2 (LATS2) gene expression correlates with EGFR mutation and survival in lung adenocarcinomas.Importin 7 and exportin 1 link c-Myc and p53 to regulation of ribosomal biogenesis Relationship of spindle assembly checkpoint fidelity to species body mass, lifespan, and developmental rate.MicroRNA-135b regulates apoptosis and chemoresistance in colorectal cancer by targeting large tumor suppressor kinase 2.Checkpoint-apoptosis uncoupling in human and mouse embryonic stem cells: a source of karyotpic instability.

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P2860

A positive feedback loop between the p53 and Lats2 tumor suppressors prevents tetraploidization

http://www.wikidata.org/entity/Q24669694

description

2006 nî lūn-bûn

@nan

2006 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած

@hyw

2006 թվականի հոտեմբերին հրատարակված գիտական հոդված

@hy

2006年の論文

@ja

2006年論文

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2006年論文

@zh-hant

2006年論文

@zh-hk

2006年論文

@zh-mo

2006年論文

@zh-tw

2006年论文

@wuu

name

A positive feedback loop betwe ...... ors prevents tetraploidization

@ast

A positive feedback loop betwe ...... ors prevents tetraploidization

@en

A positive feedback loop betwe ...... ors prevents tetraploidization

@nl

type

label

A positive feedback loop betwe ...... ors prevents tetraploidization

@ast

A positive feedback loop betwe ...... ors prevents tetraploidization

@en

A positive feedback loop betwe ...... ors prevents tetraploidization

@nl

prefLabel

A positive feedback loop betwe ...... ors prevents tetraploidization

@ast

A positive feedback loop betwe ...... ors prevents tetraploidization

@en

A positive feedback loop betwe ...... ors prevents tetraploidization

@nl

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Genes & Development

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A positive feedback loop betwe ...... ors prevents tetraploidization

@en

P2093

Ayelet Shmueli

http://www.w3.org/2001/XMLSchema#string

Hiroshi Nojima

http://www.w3.org/2001/XMLSchema#string

Norikazu Yabuta

http://www.w3.org/2001/XMLSchema#string

Yael Aylon

http://www.w3.org/2001/XMLSchema#string

P2860

A human homolog of Drosophila warts tumor suppressor, h-warts, localized to mitotic apparatus and specifically phosphorylated during mitosis

Structure, expression, and chromosome mapping of LATS2, a mammalian homologue of the Drosophila tumor suppressor gene lats/warts

Zyxin, a regulator of actin filament assembly, targets the mitotic apparatus by interacting with h-warts/LATS1 tumor suppressor

Molecular cloning of a novel human protein kinase, kpm, that is homologous to warts/lats, a Drosophila tumor suppressor

Chfr defines a mitotic stress checkpoint that delays entry into metaphase

LATS2-Ajuba complex regulates gamma-tubulin recruitment to centrosomes and spindle organization during mitosis

Lats2, a putative tumor suppressor, inhibits G1/S transition

Tumor suppressor WARTS ensures genomic integrity by regulating both mitotic progression and G1 tetraploidy checkpoint function

Assembly of centrosomal proteins and microtubule organization depends on PCM-1

Mammalian cells lack checkpoints for tetraploidy, aberrant centrosome number, and cytokinesis failure

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2687-2700

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scholarly article

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691157

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10.1101/GAD.1447006

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19

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20

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2006-10-01T00:00:00Z

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6780507

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P698

17015431

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1578695

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