A cancer cell metalloprotease triad regulates the basement membrane transmigration program
about
Hyaluronan synthase 2 (HAS2) promotes breast cancer cell invasion by suppression of tissue metalloproteinase inhibitor 1 (TIMP-1)Endosomal WASH and exocyst complexes control exocytosis of MT1-MMP at invadopodia.Microvesicles: mediators of extracellular communication during cancer progressionMMP25 (MT6-MMP) is highly expressed in human colon cancer, promotes tumor growth, and exhibits unique biochemical propertiesThe collagen receptor uPARAP/Endo180 in tissue degradation and cancer (Review)Traversing the basement membrane in vivo: a diversity of strategiesCell-cell and cell-matrix dynamics in intraperitoneal cancer metastasisEpithelial-mesenchymal plasticity in carcinoma metastasisProtein composition and biomechanical properties of in vivo-derived basement membranesARF6-JIP3/4 regulate endosomal tubules for MT1-MMP exocytosis in cancer invasion.Cells assemble invadopodia-like structures and invade into matrigel in a matrix metalloprotease dependent manner in the circular invasion assayA novel 3D fibril force assay implicates src in tumor cell force generation in collagen networksMembrane-type MMPs enable extracellular matrix permissiveness and mesenchymal cell proliferation during embryogenesisPhosphoinositide 3-kinase p85beta regulates invadopodium formation.Regulation of invadopodia formation and activity by CD147Dependence of invadopodia function on collagen fiber spacing and cross-linking: computational modeling and experimental evidence.Mapping local matrix remodeling induced by a migrating tumor cell using three-dimensional multiple-particle tracking.UNC-6 (netrin) orients the invasive membrane of the anchor cell in C. elegans.E-cadherin suppression directs cytoskeletal rearrangement and intraepithelial tumor cell migration in 3D human skin equivalents.N-WASP coordinates the delivery and F-actin-mediated capture of MT1-MMP at invasive pseudopods.Adhesion rings surround invadopodia and promote maturation.The netrin receptor DCC focuses invadopodia-driven basement membrane transmigration in vivo.M2-like macrophages are responsible for collagen degradation through a mannose receptor-mediated pathway.Control of MT1-MMP transport by atypical PKC during breast-cancer progression.A RAB5/RAB4 recycling circuitry induces a proteolytic invasive program and promotes tumor dissemination.Protein-tyrosine pseudokinase 7 (PTK7) directs cancer cell motility and metastasis.Invadosomes in their natural habitat.Regulated delivery of molecular cargo to invasive tumour-derived microvesiclesCollagen I but not Matrigel matrices provide an MMP-dependent barrier to ovarian cancer cell penetration.Inhibition of MMP-3 activity and invasion of the MDA-MB-231 human invasive breast carcinoma cell line by bioflavonoidsVenular basement membranes ubiquitously express matrix protein low-expression regions: characterization in multiple tissues and remodeling during inflammation.Antagonistic anti-urokinase plasminogen activator receptor (uPAR) antibodies significantly inhibit uPAR-mediated cellular signaling and migrationQuantitative analysis of three-dimensional human mammary epithelial tissue architecture reveals a role for tenascin-C in regulating c-met function.MT1-MMP controls human mesenchymal stem cell trafficking and differentiation.Methylation of the tumor suppressor protein, BRCA1, influences its transcriptional cofactor function.Inhibition of the transition of ductal carcinoma in situ to invasive ductal carcinoma by a Gemini vitamin D analog.Preventing tissue fibrosis by local biomaterials interfacing of specific cryptic extracellular matrix information.An in vitro model that recapitulates the epithelial to mesenchymal transition (EMT) in human breast cancer.Actin, microtubules, and vimentin intermediate filaments cooperate for elongation of invadopodiaBasement membrane sliding and targeted adhesion remodels tissue boundaries during uterine-vulval attachment in Caenorhabditis elegans.
P2860
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P2860
A cancer cell metalloprotease triad regulates the basement membrane transmigration program
description
2006 nî lūn-bûn
@nan
2006 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2006 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
name
A cancer cell metalloprotease ...... embrane transmigration program
@ast
A cancer cell metalloprotease ...... embrane transmigration program
@en
A cancer cell metalloprotease ...... embrane transmigration program
@nl
type
label
A cancer cell metalloprotease ...... embrane transmigration program
@ast
A cancer cell metalloprotease ...... embrane transmigration program
@en
A cancer cell metalloprotease ...... embrane transmigration program
@nl
prefLabel
A cancer cell metalloprotease ...... embrane transmigration program
@ast
A cancer cell metalloprotease ...... embrane transmigration program
@en
A cancer cell metalloprotease ...... embrane transmigration program
@nl
P2093
P2860
P3181
P356
P1433
P1476
A cancer cell metalloprotease ...... embrane transmigration program
@en
P2093
Edward Allen
Kevin Hotary
Stephen J Weiss
Susan L Stevens
Xiao-Yan Li
P2860
P304
P3181
P356
10.1101/GAD.1451806
P407
P577
2006-10-01T00:00:00Z