How important are entropic contributions to enzyme catalysis? - Wikidata - awgldk - TriplyDB

How important are entropic contributions to enzyme catalysis?

How important are entropic contributions to enzyme catalysis?

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Dispelling the effects of a sorceress in enzyme catalysis Drugs for allosteric sites on receptors p53 Proteoforms and Intrinsic Disorder: An Illustration of the Protein Structure-Function Continuum Concept At the dawn of the 21st century: Is dynamics the missing link for understanding enzyme catalysis?Rational design of enantioselective enzymes requires considerations of entropy Toward accurate microscopic calculation of solvation entropies: extending the restraint release approach to studies of solvation effects Biapenem inactivation by B2 metallo β-lactamases: energy landscape of the post-hydrolysis reactions Perspective: Defining and quantifying the role of dynamics in enzyme catalysis Absolute binding free energy calculations: on the accuracy of computational scoring of protein-ligand interactions Molecular modeling to provide insight into the substrate binding and catalytic mechanism of human biliverdin-IXα reductase Loop-tryptophan human purine nucleoside phosphorylase reveals submillisecond protein dynamics.Computational study on substrate specificity of a novel cysteine protease 1 precursor from Zea mays Examining the case for the effect of barrier compression on tunneling, vibrationally enhanced catalysis, catalytic entropy and related issues Biapenem inactivation by B2 metallo β-lactamases: energy landscape of the hydrolysis reaction.Preorganization and protein dynamics in enzyme catalysis.Molecular enzymology of 5-aminolevulinate synthase, the gatekeeper of heme biosynthesis.Catalysis by dihydrofolate reductase and other enzymes arises from electrostatic preorganization, not conformational motions.On the relationship between thermal stability and catalytic power of enzymes The entropic contributions in vitamin B12 enzymes still reflect the electrostatic paradigm.A new paradigm for electrostatic catalysis of radical reactions in vitamin B12 enzymes.Searching sequence space: two different approaches to dihydrofolate reductase catalysis.Quantum mechanical/molecular mechanical simulation study of the mechanism of hairpin ribozyme catalysis On the origin of the catalytic power of carboxypeptidase A and other metalloenzymes.Surface single-molecule dynamics controlled by entropy at low temperatures.Hydrogen-bond stabilization in oxyanion holes: grand jeté to three dimensions.Modelling the reaction mechanism of ribulose-1,5-bisphosphate carboxylase/oxygenase and consequences for kinetic parameters.Substrate entropy in enzyme enantioselectivity: an experimental and molecular modeling study of a lipase.Enthalpic and entropic contributions in the transesterification of sucrose: computational study of lipases and subtilisin.The role of side chain entropy and mutual information for improving the de novo design of Kemp eliminases KE07 and KE70.Stereoselectivity of chalcone isomerase with chalcone derivatives: a computational study.Contribution of translational and rotational motions to molecular association in aqueous solution.Simulating enzyme reactions: challenges and perspectives.Electrostatic origin of the catalytic effect of a supramolecular host catalyst.CXC and CC chemokines form mixed heterodimers: association free energies from molecular dynamics simulations and experimental correlations Temperature dependence of the kinetic isotope effects in thymidylate synthase. A theoretical study.The measured and calculated affinity of methyl- and methoxy-substituted benzoquinones for the Q(A) site of bacterial reaction centers.Methyltransferases do not work by compression, cratic, or desolvation effects, but by electrostatic preorganization.Determinants of reactivity and selectivity in soluble epoxide hydrolase from quantum mechanics/molecular mechanics modeling.On the generation of catalytic antibodies by transition state analogues.Simulating electrostatic energies in proteins: perspectives and some recent studies of pKas, redox, and other crucial functional properties.

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P2860

How important are entropic contributions to enzyme catalysis?

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2000 nî lūn-bûn

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2000年の論文

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How important are entropic contributions to enzyme catalysis?

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How important are entropic contributions to enzyme catalysis?

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How important are entropic contributions to enzyme catalysis?

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P2860

Entropic contributions to rate accelerations in enzymic and intramolecular reactions and the chelate effect

So do we understand how enzymes work?

Evaluation of catalytic free energies in genetically modified proteins.

Electrostatic origin of the catalytic power of enzymes and the role of preorganized active sites.

Computer simulations with explicit solvent: recent progress in the thermodynamic decomposition of free energies and in modeling electrostatic effects.

Ground State and Transition State Contributions to the Rates of Intramolecular and Enzymatic Reactions

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