Differential pharmacology between the guinea-pig and the gorilla 5-HT1D receptor as probed with isochromans (5-HT1D-selective ligands) - Wikidata - awgldk - TriplyDB

Differential pharmacology between the guinea-pig and the gorilla 5-HT1D receptor as probed with isochromans (5-HT1D-selective ligands)

Differential pharmacology between the guinea-pig and the gorilla 5-HT1D receptor as probed with isochromans (5-HT1D-selective ligands)

http://www.wikidata.org/entity/Q24672188

about

The anti-migraine 5-HT(1B/1D) agonist rizatriptan inhibits neurogenic dural vasodilation in anaesthetized guinea-pigs The GR127935-sensitive 5-HT(1) receptors mediating canine internal carotid vasoconstriction: resemblance to the 5-HT(1B), but not to the 5-HT(1D) or 5-ht(1F), receptor subtype Neurogenic inflammation in the context of migraine.Pharmacological profile of the 5-HT-induced inhibition of cardioaccelerator sympathetic outflow in pithed rats: correlation with 5-HT1 and putative 5-ht5A/5B receptors.Molecular cloning, sequence analysis and pharmacological properties of the porcine 5-HT(1D) receptor Can we develop neurally acting drugs for the treatment of migraine?New migraine and pain research.Donitriptan, but not sumatriptan, inhibits capsaicin-induced canine external carotid vasodilatation via 5-HT1B rather than 5-HT1D receptors.Advances in drug development for acute migraine.Acute migraine therapy: new drugs and new approaches.An immunocytochemical investigation of human trigeminal nucleus caudalis: CGRP, substance P and 5-HT1D-receptor immunoreactivities are expressed by trigeminal sensory fibres.

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P2860

Differential pharmacology between the guinea-pig and the gorilla 5-HT1D receptor as probed with isochromans (5-HT1D-selective ligands)

http://www.wikidata.org/entity/Q24672188

description

1999 nî lūn-bûn

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1999 թուականի Մայիսին հրատարակուած գիտական յօդուած

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1999 թվականի մայիսին հրատարակված գիտական հոդված

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1999年の論文

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G L Alberts

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J F Pregenzer

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J L Slightom

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M D Ennis

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N B Ghazal

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R L Hoffman

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P2860

Human serotonin 1D receptor is encoded by a subfamily of two distinct genes: 5-HT1D alpha and 5-HT1D beta

Chimeric mutagenesis of putative G-protein coupling domains of the alpha2A-adrenergic receptor. Localization of two redundant and fully competent gi coupling domains.

Selective amplification and cloning of four new members of the G protein-coupled receptor family

Engineering hybrid genes without the use of restriction enzymes: gene splicing by overlap extension

Characterization of the human 5-hydroxytryptamine1B receptor.

Conformationally restricted sumatriptan analogues, CP-122,288 and CP-122,638 exhibit enhanced potency against neurogenic inflammation in dura mater.

Differential expression of sumatriptan-sensitive 5-hydroxytryptamine receptors in human trigeminal ganglia and cerebral blood vessels.

Neurogenic inflammation in the pathophysiology and treatment of migraine.

Selective 5-HT1D alpha serotonin receptor gene expression in trigeminal ganglia: implications for antimigraine drug development.

Characterization of ligand binding properties of the 5-HT1D receptors cloned from chimpanzee, gorilla and rhesus monkey in comparison with those from the human and guinea pig receptors.

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