QSulf1 remodels the 6-O sulfation states of cell surface heparan sulfate proteoglycans to promote Wnt signaling
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Secreted sulfatases Sulf1 and Sulf2 have overlapping yet essential roles in mouse neonatal survivalGlypicansMouse cristin/R-spondin family proteins are novel ligands for the Frizzled 8 and LRP6 receptors and activate beta-catenin-dependent gene expressionCharacterization of the human sulfatase Sulf1 and its high affinity heparin/heparan sulfate interaction domainDirect detection of HSulf-1 and HSulf-2 activities on extracellular heparan sulfate and their inhibition by PI-88Functional consequences of the subdomain organization of the sulfsHSulf-2, an extracellular endoglucosamine-6-sulfatase, selectively mobilizes heparin-bound growth factors and chemokines: effects on VEGF, FGF-1, and SDF-1.Sulf-2, a proangiogenic heparan sulfate endosulfatase, is upregulated in breast cancerHeparan sulphate synthetic and editing enzymes in ovarian cancerExpression of novel extracellular sulfatases Sulf-1 and Sulf-2 in normal and osteoarthritic articular cartilageGene trap disruption of the mouse heparan sulfate 6-O-endosulfatase gene, Sulf2Heparan sulfate 6-O-endosulfatases: discrete in vivo activities and functional co-operativityProteoglycans and neuronal migration in the cerebral cortex during development and diseaseExtracellular distribution of diffusible growth factors controlled by heparan sulfate proteoglycans during mammalian embryogenesisEngineering of routes to heparin and related polysaccharidesHeparan sulfate regulates the number and centrosome positioning of Drosophila male germline stem cellsThe SULFs, extracellular sulfatases for heparan sulfate, promote the migration of corneal epithelial cells during wound repairA targeted glycan-related gene screen reveals heparan sulfate proteoglycan sulfation regulates WNT and BMP trans-synaptic signalingStructural insights into proteoglycan-shaped Hedgehog signalingRole of the Wnt/β-catenin pathway in gastric cancer: An in-depth literature reviewProcessing by convertases is not required for glypican-3-induced stimulation of hepatocellular carcinoma growthRedundant function of the heparan sulfate 6-O-endosulfatases Sulf1 and Sulf2 during skeletal developmentSulf1 and Sulf2 Differentially Modulate Heparan Sulfate Proteoglycan Sulfation during Postnatal Cerebellum Development: Evidence for Neuroprotective and Neurite Outgrowth Promoting FunctionsThe loss of glypican-3 induces alterations in Wnt signalingSulfatase 1 is an inhibitor of ductal morphogenesis with sexually dimorphic expression in the urogenital sinusMice deficient in heparan sulfate 6-O-sulfotransferase-1 exhibit defective heparan sulfate biosynthesis, abnormal placentation, and late embryonic lethalityMitogenic activity of sulfated chitosan and cellulose derivatives is related to protection of FGF-2 from proteolytic cleavage.Wnt proteins.FGF8 signaling is chemotactic for cardiac neural crest cells.Fell-Muir Lecture: Heparan sulphate and the art of cell regulation: a polymer chain conducts the protein orchestra.3-O-sulfated oligosaccharide structures are recognized by anti-heparan sulfate antibody HS4C3.Substrate specificity and domain functions of extracellular heparan sulfate 6-O-endosulfatases, QSulf1 and QSulf2.Novel markers for differentiation of lobular and ductal invasive breast carcinomas by laser microdissection and microarray analysis.Extracellular sulfatases, elements of the Wnt signaling pathway, positively regulate growth and tumorigenicity of human pancreatic cancer cellsSubstrate specificity of 6-O-endosulfatase (Sulf-2) and its implications in synthesizing anticoagulant heparan sulfate.Screening for anticoagulant heparan sulfate octasaccharides and fine structure characterization using tandem mass spectrometryGrowth Differentiation Factor 5-Mediated Enhancement of Chondrocyte Phenotype Is Inhibited by Heparin: Implications for the Use of Heparin in the Clinic and in Tissue Engineering Applications.Human Sulfatase 2 inhibits in vivo tumor growth of MDA-MB-231 human breast cancer xenografts.Regulation of intracellular signaling by extracellular glycan remodeling.Heparin Promotes Cardiac Differentiation of Human Pluripotent Stem Cells in Chemically Defined Albumin-Free Medium, Enabling Consistent Manufacture of Cardiomyocytes
P2860
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P2860
QSulf1 remodels the 6-O sulfation states of cell surface heparan sulfate proteoglycans to promote Wnt signaling
description
2003 nî lūn-bûn
@nan
2003 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2003 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
name
QSulf1 remodels the 6-O sulfat ...... ycans to promote Wnt signaling
@ast
QSulf1 remodels the 6-O sulfat ...... ycans to promote Wnt signaling
@en
QSulf1 remodels the 6-O sulfat ...... ycans to promote Wnt signaling
@nl
type
label
QSulf1 remodels the 6-O sulfat ...... ycans to promote Wnt signaling
@ast
QSulf1 remodels the 6-O sulfat ...... ycans to promote Wnt signaling
@en
QSulf1 remodels the 6-O sulfat ...... ycans to promote Wnt signaling
@nl
prefLabel
QSulf1 remodels the 6-O sulfat ...... ycans to promote Wnt signaling
@ast
QSulf1 remodels the 6-O sulfat ...... ycans to promote Wnt signaling
@en
QSulf1 remodels the 6-O sulfat ...... ycans to promote Wnt signaling
@nl
P2860
P50
P3181
P356
P1476
QSulf1 remodels the 6-O sulfat ...... ycans to promote Wnt signaling
@en
P2093
Charles P Emerson
Olga Lozynska
P2860
P304
P3181
P356
10.1083/JCB.200212083
P407
P577
2003-07-21T00:00:00Z