Human Mcm10 regulates the catalytic subunit of DNA polymerase-alpha and prevents DNA damage during replication - Wikidata - awgldk - TriplyDB

Human Mcm10 regulates the catalytic subunit of DNA polymerase-alpha and prevents DNA damage during replication

Human Mcm10 regulates the catalytic subunit of DNA polymerase-alpha and prevents DNA damage during replication

http://www.wikidata.org/entity/Q24680096

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Structural basis for DNA binding by replication initiator Mcm10 Physical Interactions between Mcm10, DNA, and DNA Polymerase Solution NMR Structure of the C-terminal DNA Binding Domain of Mcm10 Reveals a Conserved MCM Motif Mcm10 Self-Association Is Mediated by an N-Terminal Coiled-Coil Domain Mcm10 associates with the loaded DNA helicase at replication origins and defines a novel step in its activation.A key role for Ctf4 in coupling the MCM2-7 helicase to DNA polymerase alpha within the eukaryotic replisome.An Mcm10 Mutant Defective in ssDNA Binding Shows Defects in DNA Replication Initiation Drosophila Mcm10 is required for DNA replication and differentiation in the compound eye A DNA polymerase-{alpha}{middle dot}primase cofactor with homology to replication protein A-32 regulates DNA replication in mammalian cells RecQL4 is required for the association of Mcm10 and Ctf4 with replication origins in human cells Xenopus DNA2 is a helicase/nuclease that is found in complexes with replication proteins And-1/Ctf4 and Mcm10 and DSB response proteins Nbs1 and ATM Cloning, expression, purification, crystallization and preliminary X-ray diffraction analysis of the central zinc-binding domain of the human Mcm10 DNA-replication factor Novel roles of HP1a and Mcm10 in DNA replication, genome maintenance and photoreceptor cell differentiation.Ultraviolet radiation stress triggers the down-regulation of essential replication factor Mcm10.The N-terminus of Mcm10 is important for interaction with the 9-1-1 clamp and in resistance to DNA damage.Characterization of Leishmania donovani MCM4: expression patterns and interaction with PCNA.Multiple functions for Drosophila Mcm10 suggested through analysis of two Mcm10 mutant alleles Ubc4 and Not4 regulate steady-state levels of DNA polymerase-α to promote efficient and accurate DNA replication.Evolution of CST function in telomere maintenance.Mcm10 plays an essential role in origin DNA unwinding after loading of the CMG components Archaeology of eukaryotic DNA replication Reduced expression of GINS complex members induces hallmarks of pre-malignancy in primary untransformed human cells A transcriptome-based model of central memory CD4 T cell death in HIV infection.Emerging players in the initiation of eukaryotic DNA replication.miR-671-5p inhibits epithelial-to-mesenchymal transition by downregulating FOXM1 expression in breast cancer Assembly of the Cdc45-Mcm2-7-GINS complex in human cells requires the Ctf4/And-1, RecQL4, and Mcm10 proteins.Nuclear export factor RBM15 facilitates the access of DBP5 to mRNA Structural biology of replication initiation factor Mcm10.Enigmatic roles of Mcm10 in DNA replication MCM10: one tool for all-Integrity, maintenance and damage control.Relationships between deficits in tissue mass and transcriptional programs after partial hepatectomy in mice Ataxia telangiectasia-mutated damage-signaling kinase- and proteasome-dependent destruction of Mre11-Rad50-Nbs1 subunits in Simian virus 40-infected primate cells Overexpression of minichromosome maintenance protein 10 in medulloblastoma and its clinical implications.Gata6 promotes hair follicle progenitor cell renewal by genome maintenance during proliferation.Mcm10: A Dynamic Scaffold at Eukaryotic Replication Forks Slx5/Slx8 Promotes Replication Stress Tolerance by Facilitating Mitotic Progression Human Stn1 protects telomere integrity by promoting efficient lagging-strand synthesis at telomeres and mediating C-strand fill-in.Xenopus Mcm10 is a CDK-substrate required for replication fork stability.Discovery of gene expression-based pharmacodynamic biomarker for a p53 context-specific anti-tumor drug Wee1 inhibitor.DNA-Directed Polymerase Subunits Play a Vital Role in Human Telomeric Overhang Processing.

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Human Mcm10 regulates the catalytic subunit of DNA polymerase-alpha and prevents DNA damage during replication

http://www.wikidata.org/entity/Q24680096

description

2007 nî lūn-bûn

@nan

2007 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած

@hyw

2007 թվականի հոտեմբերին հրատարակված գիտական հոդված

@hy

2007年の論文

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2007年論文

@yue

2007年論文

@zh-hant

2007年論文

@zh-hk

2007年論文

@zh-mo

2007年論文

@zh-tw

2007年论文

@wuu

name

Human Mcm10 regulates the cata ...... DNA damage during replication

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Human Mcm10 regulates the cata ...... DNA damage during replication

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Human Mcm10 regulates the cata ...... DNA damage during replication

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type

label

Human Mcm10 regulates the cata ...... DNA damage during replication

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Human Mcm10 regulates the cata ...... DNA damage during replication

@en

Human Mcm10 regulates the cata ...... DNA damage during replication

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prefLabel

Human Mcm10 regulates the cata ...... DNA damage during replication

@ast

Human Mcm10 regulates the cata ...... DNA damage during replication

@en

Human Mcm10 regulates the cata ...... DNA damage during replication

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MBC.E06-12-1148

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Molecular Biology of the Cell

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Human Mcm10 regulates the cata ...... DNA damage during replication

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Anja-Katrin Bielinsky

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Sharbani Chattopadhyay

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P2860

The human homolog of Saccharomyces cerevisiae Mcm10 interacts with replication factors and dissociates from nuclease-resistant nuclear structures in G(2) phase

Human Orc2 localizes to centrosomes, centromeres and heterochromatin during chromosome inheritance

Isolation of the Cdc45/Mcm2-7/GINS (CMG) complex, a candidate for the eukaryotic DNA replication fork helicase

A requirement for MCM7 and Cdc45 in chromosome unwinding during eukaryotic DNA replication

GINS, a novel multiprotein complex required for chromosomal DNA replication in budding yeast

Drosophila MCM10 interacts with members of the prereplication complex and is required for proper chromosome condensation

Nuclear distribution and chromatin association of DNA polymerase alpha-primase is affected by TEV protease cleavage of Cdc23 (Mcm10) in fission yeast.

Uninterrupted MCM2-7 function required for DNA replication fork progression.

Mcm10 regulates the stability and chromatin association of DNA polymerase-alpha.

Components and dynamics of DNA replication complexes in S. cerevisiae: redistribution of MCM proteins and Cdc45p during S phase

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10.1091/MBC.E06-12-1148

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