Cdc6 is regulated by E2F and is essential for DNA replication in mammalian cells - Wikidata - awgldk - TriplyDB

Cdc6 is regulated by E2F and is essential for DNA replication in mammalian cells

Cdc6 is regulated by E2F and is essential for DNA replication in mammalian cells

http://www.wikidata.org/entity/Q24682117

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A novel growth- and cell cycle-regulated protein, ASK, activates human Cdc7-related kinase and is essential for G1/S transition in mammalian cells PR48, a novel regulatory subunit of protein phosphatase 2A, interacts with Cdc6 and modulates DNA replication in human cells The regulated association of Cdt1 with minichromosome maintenance proteins and Cdc6 in mammalian cells Chromatin association of human origin recognition complex, cdc6, and minichromosome maintenance proteins during the cell cycle: assembly of prereplication complexes in late mitosis Cdc6 protein causes premature entry into S phase in a mammalian cell-free system.Phosphorylation of mammalian CDC6 by cyclin A/CDK2 regulates its subcellular localization Regulation of CDC6, geminin, and CDT1 in human cells that undergo polyploidization Interaction of YY1 with E2Fs, mediated by RYBP, provides a mechanism for specificity of E2F function CDC25A phosphatase is a target of E2F and is required for efficient E2F-induced S phase Cell cycle- and cell growth-regulated proteolysis of mammalian CDC6 is dependent on APC-CDH1 Prevention of DNA re-replication in eukaryotic cells Protein phosphatase 2A is targeted to cell division control protein 6 by a calcium-binding regulatory subunit Multistep regulation of DNA replication by Cdk phosphorylation of HsCdc6 Selective instability of Orc1 protein accounts for the absence of functional origin recognition complexes during the M-G(1) transition in mammals Global gene expression analysis in time series following N-acetyl L-cysteine induced epithelial differentiation of human normal and cancer cells in vitro Cell growth-regulated expression of mammalian MCM5 and MCM6 genes mediated by the transcription factor E2F A 63-base pair DNA segment containing an Sp1 site but not a canonical E2F site can confer growth-dependent and E2F-mediated transcriptional stimulation of the human ASK gene encoding the regulatory subunit for human Cdc7-related kinase CDC6: from DNA replication to cell cycle checkpoints and oncogenesis Cell cycle-dependent recruitment of HDAC-1 correlates with deacetylation of histone H4 on an Rb-E2F target promoter Mammalian MCM loading in late-G(1) coincides with Rb hyperphosphorylation and the transition to post-transcriptional control of progression into S-phase Binding of AlF-C, an Orc1-binding transcriptional regulator, enhances replicator activity of the rat aldolase B origin The Cdc6 nucleotide-binding site regulates its activity in DNA replication in human cells Identification of genes periodically expressed in the human cell cycle and their expression in tumors A potential role for mini-chromosome maintenance (MCM) proteins in initiation at the dihydrofolate reductase replication origin.Cdc6 chromatin affinity is unaffected by serine-54 phosphorylation, S-phase progression, and overexpression of cyclin A.Cell-Based Systems Biology Analysis of Human AS03-Adjuvanted H5N1 Avian Influenza Vaccine Responses: A Phase I Randomized Controlled Trial Cdc6 and cyclin E2 are PTEN-regulated genes associated with human prostate cancer metastasis A CDC6 protein-binding peptide selected using a bacterial two-hybrid-like system is a cell cycle inhibitor.Identification of key transcription factors in caerulein-induced pancreatitis through expression profiling data.Cell cycle regulation of the murine cdc25B promoter: essential role for nuclear factor-Y and a proximal repressor element.Down-regulation of Cdc6, a cell cycle regulatory gene, in prostate cancer.Towards a systems biology approach to mammalian cell cycle: modeling the entrance into S phase of quiescent fibroblasts after serum stimulation.Activation of Cdc6 by MyoD is associated with the expansion of quiescent myogenic satellite cells.Cloning and characterization of the 5'-upstream sequence governing the cell cycle-dependent transcription of mouse DNA polymerase alpha 68 kDa subunit gene Overexpression of FABP3 inhibits human bone marrow derived mesenchymal stem cell proliferation but enhances their survival in hypoxia Targeted destruction of DNA replication protein Cdc6 by cell death pathways in mammals and yeast.Cell cycle regulators: mechanisms and their role in aetiology, prognosis, and treatment of cancer.Cell cycle regulation of human CDC6 protein. Intracellular localization, interaction with the human mcm complex, and CDC2 kinase-mediated hyperphosphorylation.A novel function of adenovirus E1A is required to overcome growth arrest by the CDK2 inhibitor p27(Kip1).Molecular and genetic aspects of lung cancer.

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Cdc6 is regulated by E2F and is essential for DNA replication in mammalian cells

http://www.wikidata.org/entity/Q24682117

description

1998 nî lūn-bûn

@nan

1998 թուականի Մարտին հրատարակուած գիտական յօդուած

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1998 թվականի մարտին հրատարակված գիտական հոդված

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1998年の論文

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1998年学术文章

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1998年学术文章

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1998年学术文章

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1998年学术文章

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1998年学术文章

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1998年學術文章

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name

Cdc6 is regulated by E2F and is essential for DNA replication in mammalian cells

@ast

Cdc6 is regulated by E2F and is essential for DNA replication in mammalian cells

@en

Cdc6 is regulated by E2F and is essential for DNA replication in mammalian cells

@nl

type

label

Cdc6 is regulated by E2F and is essential for DNA replication in mammalian cells

@ast

Cdc6 is regulated by E2F and is essential for DNA replication in mammalian cells

@en

Cdc6 is regulated by E2F and is essential for DNA replication in mammalian cells

@nl

prefLabel

Cdc6 is regulated by E2F and is essential for DNA replication in mammalian cells

@ast

Cdc6 is regulated by E2F and is essential for DNA replication in mammalian cells

@en

Cdc6 is regulated by E2F and is essential for DNA replication in mammalian cells

@nl

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Proceedings of the National Academy of Sciences of the United States of America

P1476

Cdc6 is regulated by E2F and is essential for DNA replication in mammalian cells

@en

P2093

B Stillman

http://www.w3.org/2001/XMLSchema#string

G Leone

http://www.w3.org/2001/XMLSchema#string

J DeGregori

http://www.w3.org/2001/XMLSchema#string

J R Nevins

http://www.w3.org/2001/XMLSchema#string

R S Williams

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R Shohet

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Z Yan

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P2860

Conserved initiator proteins in eukaryotes

A human protein related to yeast Cdc6p

Expression of the HsOrc1 gene, a human ORC1 homolog, is regulated by cell proliferation via the E2F transcription factor

The retinoblastoma protein and cell cycle control

An essential role for the Cdc6 protein in forming the pre-replicative complexes of budding yeast.

Loading of an Mcm protein onto DNA replication origins is regulated by Cdc6p and CDKs.

A novel Mcm1-dependent element in the SWI4, CLN3, CDC6, and CDC47 promoters activates M/G1-specific transcription.

Cdc6p-dependent loading of Mcm proteins onto pre-replicative chromatin in budding yeast.

ATP-dependent recognition of eukaryotic origins of DNA replication by a multiprotein complex

The Xenopus Cdc6 protein is essential for the initiation of a single round of DNA replication in cell-free extracts

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2836422

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10.1073/PNAS.95.7.3603

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7

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95

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235614439

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9520412

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19882

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