Promiscuous drugs compared to selective drugs (promiscuity can be a virtue) - Wikidata - awgldk - TriplyDB

Promiscuous drugs compared to selective drugs (promiscuity can be a virtue)

Promiscuous drugs compared to selective drugs (promiscuity can be a virtue)

http://www.wikidata.org/entity/Q24799034

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Novel frontiers in epilepsy treatments: preventing epileptogenesis by targeting inflammation Structure and dynamics of molecular networks: a novel paradigm of drug discovery: a comprehensive review Phenocopy--a strategy to qualify chemical compounds during hit-to-lead and/or lead optimization Statistical properties and robustness of biological controller-target networks A system-level investigation into the mechanisms of Chinese Traditional Medicine: Compound Danshen Formula for cardiovascular disease treatment Drug Promiscuity in PDB: Protein Binding Site Similarity Is Key A network pharmacology approach to understanding the mechanisms of action of traditional medicine: Bushenhuoxue formula for treatment of chronic kidney disease Selectivity by small-molecule inhibitors of protein interactions can be driven by protein surface fluctuations VNP: Interactive Visual Network Pharmacology of Diseases, Targets, and Drugs Distribution patterns of small-molecule ligands in the protein universe and implications for origin of life and drug discovery Non-monotonic dynamics and crosstalk in signaling pathways and their implications for pharmacology Method for comparing the structures of protein ligand-binding sites and application for predicting protein-drug interactions.Promiscuity and the conformational rearrangement of drug-like molecules: insight from the protein data bank.Integrated mechanistic and data-driven modelling for multivariate analysis of signalling pathways.Targeting ligand-gated ion channels in neurology and psychiatry: is pharmacological promiscuity an obstacle or an opportunity?Computational methods for early predictive safety assessment from biological and chemical data.Modification of cysteine 179 of IkappaBalpha kinase by nimbolide leads to down-regulation of NF-kappaB-regulated cell survival and proliferative proteins and sensitization of tumor cells to chemotherapeutic agents Plastic and Neuroprotective Mechanisms Involved in the Therapeutic Effects of Cannabidiol in Psychiatric Disorders.Naturally occurring multipotent anti-Alzheimer's agents.Finding novel pharmaceuticals in the systems biology era using multiple effective drug targets, phenotypic screening and knowledge of transporters: where drug discovery went wrong and how to fix it.Beyond the CB1 Receptor: Is Cannabidiol the Answer for Disorders of Motivation?Role of nuclear factor κB-mediated inflammatory pathways in cancer-related symptoms and their regulation by nutritional agents.BalestraWeb: efficient online evaluation of drug-target interactions.Comprehensive assay of kinase catalytic activity reveals features of kinase inhibitor selectivity.Cancer cell cytotoxicities of 1-(4-substitutedbenzoyl)-4-(4-chlorobenzhydryl)piperazine derivatives.A general mechanism for drug promiscuity: Studies with amiodarone and other antiarrhythmics Therapeutic roles of curcumin: lessons learned from clinical trials.Dual EGFR and mTOR targeting in squamous cell carcinoma models, and development of early markers of efficacy.Rational Polypharmacology: Systematically Identifying and Engaging Multiple Drug Targets To Promote Axon Growth.The prince and the pauper. A tale of anticancer targeted agents.Multiplicity of effectors of the cardioprotective agent, diazoxide.A Partial Response to Reintroduced Chemotherapy in a Resistant Small Cell Lung Cancer Patient After Priming with RRx-001.CVDHD: a cardiovascular disease herbal database for drug discovery and network pharmacology.Old friends in new guise: repositioning of known drugs with structural bioinformatics.Building a drug-target network and its applications.Computational methods for analysis and inference of kinase/inhibitor relationships.Exploring the epigenetic drug discovery landscape.Integration of phytochemicals and phytotherapy into cancer precision medicine.An HRE-Binding Py-Im Polyamide Impairs Hypoxic Signaling in Tumors.Phenotypic screening with primary neurons to identify drug targets for regeneration and degeneration.

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P2860

Promiscuous drugs compared to selective drugs (promiscuity can be a virtue)

http://www.wikidata.org/entity/Q24799034

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2005 թուականի Ապրիլին հրատարակուած գիտական յօդուած

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Promiscuous drugs compared to selective drugs (promiscuity can be a virtue)

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Promiscuous drugs compared to selective drugs (promiscuity can be a virtue)

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Long G Wang

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Emergence of Scaling in Random Networks

Network biology: understanding the cell's functional organization

Crosstalk between cAMP-dependent kinase and MAP kinase through a protein tyrosine phosphatase

Inverse association between nonsteroidal anti-inflammatory drugs and prostate cancer

Aspirin and other cyclooxygenase inhibitors: new therapeutic insights

Chemokines and disease

Philadelphia chromosome-positive leukemias: from basic mechanisms to molecular therapeutics

COX-2 inhibition and colorectal cancer

COX-2 selective inhibitors cardiac toxicity: getting to the heart of the matter

Magic shotguns versus magic bullets: selectively non-selective drugs for mood disorders and schizophrenia

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