8-oxoguanine incorporation into DNA repeats in vitro and mismatch recognition by MutSalpha. - Wikidata - awgldk - TriplyDB

8-oxoguanine incorporation into DNA repeats in vitro and mismatch recognition by MutSalpha.

8-oxoguanine incorporation into DNA repeats in vitro and mismatch recognition by MutSalpha.

http://www.wikidata.org/entity/Q24816005

about

Base excision repair and cancer DNA mismatch repair in eukaryotes and bacteria Methotrexate induces oxidative DNA damage and is selectively lethal to tumour cells with defects in the DNA mismatch repair gene MSH2 Critical amino acids in human DNA polymerases eta and kappa involved in erroneous incorporation of oxidized nucleotides.DNA polymerases as potential therapeutic targets for cancers deficient in the DNA mismatch repair proteins MSH2 or MLH1 Inactivation of the DNA repair genes mutS, mutL or the anti-recombination gene mutS2 leads to activation of vitamin B1 biosynthesis genes.DNA mismatch repair and oxidative DNA damage: implications for cancer biology and treatment.Salvage of oxidized guanine derivatives in the (2'-deoxy)ribonucleotide pool as source of mutations in DNA.Cytosine-based nucleoside analogs are selectively lethal to DNA mismatch repair-deficient tumour cells by enhancing levels of intracellular oxidative stress.Restoration of mismatch repair functions in human cell line Nalm-6, which has high efficiency for gene targeting.Error-free bypass of 2-hydroxyadenine by human DNA polymerase lambda with Proliferating Cell Nuclear Antigen and Replication Protein A in different sequence contexts.Replication of 2-hydroxyadenine-containing DNA and recognition by human MutSalpha.Klenow Fragment Discriminates against the Incorporation of the Hyperoxidized dGTP Lesion Spiroiminodihydantoin into DNA.DNA repair of oxidative DNA damage in human carcinogenesis: potential application for cancer risk assessment and prevention Oxidized dNTPs and the OGG1 and MUTYH DNA glycosylases combine to induce CAG/CTG repeat instability.The polymerase eta translesion synthesis DNA polymerase acts independently of the mismatch repair system to limit mutagenesis caused by 7,8-dihydro-8-oxoguanine in yeast.Sources of extracellular, oxidatively-modified DNA lesions: implications for their measurement in urine.MUTYH mediates the toxicity of combined DNA 6-thioguanine and UVA radiation.DNA repair and the origins of urinary oxidized 2'-deoxyribonucleosides.

P2860

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P2860

8-oxoguanine incorporation into DNA repeats in vitro and mismatch recognition by MutSalpha.

http://www.wikidata.org/entity/Q24816005

description

2005 nî lūn-bûn

@nan

2005 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած

@hyw

2005 թվականի սեպտեմբերին հրատարակված գիտական հոդված

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2005年の論文

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2005年学术文章

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2005年学术文章

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2005年学术文章

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2005年学术文章

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2005年学术文章

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2005年學術文章

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name

8-oxoguanine incorporation int ...... match recognition by MutSalpha

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8-oxoguanine incorporation int ...... atch recognition by MutSalpha.

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8-oxoguanine incorporation int ...... atch recognition by MutSalpha.

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type

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8-oxoguanine incorporation int ...... match recognition by MutSalpha

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8-oxoguanine incorporation int ...... atch recognition by MutSalpha.

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8-oxoguanine incorporation int ...... atch recognition by MutSalpha.

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prefLabel

8-oxoguanine incorporation int ...... match recognition by MutSalpha

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8-oxoguanine incorporation int ...... atch recognition by MutSalpha.

@ast

8-oxoguanine incorporation int ...... atch recognition by MutSalpha.

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Nucleic Acids Research

P1476

8-oxoguanine incorporation int ...... atch recognition by MutSalpha.

@en

P2093

Filomena Mazzei

http://www.w3.org/2001/XMLSchema#string

Flavia Barone

http://www.w3.org/2001/XMLSchema#string

Giovanni Maga

http://www.w3.org/2001/XMLSchema#string

Margherita Bignami

http://www.w3.org/2001/XMLSchema#string

Peter Karran

http://www.w3.org/2001/XMLSchema#string

Peter Macpherson

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P2860

Activation of human MutS homologs by 8-oxo-guanine DNA damage

Cloning and expression of cDNA for a human enzyme that hydrolyzes 8-oxo-dGTP, a mutagenic substrate for DNA synthesis

A novel mechanism for preventing mutations caused by oxidation of guanine nucleotides.

Spontaneous tumorigenesis in mice defective in the MTH1 gene encoding 8-oxo-dGTPase

Accumulation of premutagenic DNA lesions in mice defective in removal of oxidative base damage

Structural basis for recognition and repair of the endogenous mutagen 8-oxoguanine in DNA

Crystal structures of mismatch repair protein MutS and its complex with a substrate DNA

The crystal structure of DNA mismatch repair protein MutS binding to a G x T mismatch

Eukaryotic DNA mismatch repair.

GTBP, a 160-kilodalton protein essential for mismatch-binding activity in human cells

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5094-5105

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scholarly article

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10.1093/NAR/GKI813

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16

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33

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2005-09-20T00:00:00Z

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7588763

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16174844

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1233161

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