The challenges of dealing with promiscuous drug-metabolizing enzymes, receptors and transporters
about
The aryl hydrocarbon receptor interacts with nuclear factor erythroid 2-related factor 2 to mediate induction of NAD(P)H:quinoneoxidoreductase 1 by 2,3,7,8-tetrachlorodibenzo-p-dioxinOverview of AHR functional domains and the classical AHR signaling pathway: induction of drug-metabolizing enzymesNRF2 cysteine residues are critical for oxidant/electrophile-sensing, Kelch-like ECH-associated protein-1-dependent ubiquitination-proteasomal degradation, and transcription activationHow drugs get into cells: tested and testable predictions to help discriminate between transporter-mediated uptake and lipoidal bilayer diffusionBiology of PXR: role in drug-hormone interactionsCytochrome P450 2B diversity and dietary novelty in the herbivorous, desert woodrat (Neotoma lepida)Peroxygenase activity of cytochrome c peroxidase and three apolar distal heme pocket mutants: hydroxylation of 1-methoxynaphthalene.A large-scale allosteric transition in cytochrome P450 3A4 revealed by luminescence resonance energy transfer (LRET).Conformational Mobility in Cytochrome P450 3A4 Explored by Pressure-Perturbation EPR SpectroscopyTPMT Polymorphism: When Shield Becomes Weakness.Human Cytochrome P450 Enzyme Modulation by Gymnema sylvestre: A Predictive Safety Evaluation by LC-MS/MSElectron transfer in the complex of membrane-bound human cytochrome P450 3A4 with the flavin domain of P450BM-3: the effect of oligomerization of the heme protein and intermittent modulation of the spin equilibrium.
P2860
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P2860
The challenges of dealing with promiscuous drug-metabolizing enzymes, receptors and transporters
description
2008 nî lūn-bûn
@nan
2008 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2008 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
name
The challenges of dealing with ...... es, receptors and transporters
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The challenges of dealing with ...... es, receptors and transporters
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The challenges of dealing with ...... es, receptors and transporters
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label
The challenges of dealing with ...... es, receptors and transporters
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The challenges of dealing with ...... es, receptors and transporters
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The challenges of dealing with ...... es, receptors and transporters
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The challenges of dealing with ...... es, receptors and transporters
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The challenges of dealing with ...... es, receptors and transporters
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The challenges of dealing with ...... es, receptors and transporters
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The challenges of dealing with ...... es, receptors and transporters
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Anthony Y H Lu
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10.2174/138920008784746337
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P50
P577
2008-06-01T00:00:00Z