sameAs
Oncology exploration: charting cancer medicinal chemistry space.Synthesis and serotonin transporter activity of sulphur-substituted alpha-alkyl phenethylamines as a new class of anticancer agents.Comprehensive characterization of cytochrome P450 isozyme selectivity across chemical libraries.Identification of plasmepsin inhibitors as selective anti-malarial agents using ligand based drug design.Synthesis and evaluation of azetidinone analogues of combretastatin A-4 as tubulin targeting agents.Lead identification of β-lactam and related imine inhibitors of the molecular chaperone heat shock protein 90.On the molecular pathology of neurodegeneration in IMPDH1-based retinitis pigmentosa.Retinazone inhibits certain blood-borne human viruses including Ebola virus Zaire.Virtual screening of the estrogen receptor.Molecular topology applied to the discovery of 1-benzyl-2-(3-fluorophenyl)-4-hydroxy-3-(3-phenylpropanoyl)-2H-pyrrole-5-one as a non-ligand-binding-pocket antiandrogen.Macrophage migration inhibitory factor (MIF) enzymatic activity and lung cancer.Consensus Computational Ligand-Based Design for the Identification of Novel Modulators of Human Estrogen Receptor Alpha.Beyond the ligand-binding pocket: targeting alternate sites in nuclear receptors.Guanidinium-based derivatives: searching for new kinase inhibitors.Synthesis, biochemical and molecular modelling studies of antiproliferative azetidinones causing microtubule disruption and mitotic catastrophe.Synthesis, evaluation and structural studies of antiproliferative tubulin-targeting azetidin-2-ones.Lead identification of conformationally restricted β-lactam type combretastatin analogues: synthesis, antiproliferative activity and tubulin targeting effects.The vascular targeting agent combretastatin-A4 and a novel cis-Restricted {beta}-Lactam Analogue, CA-432, induce apoptosis in human chronic myeloid leukemia cells and ex vivo patient samples including those displaying multidrug resistance.Lead identification of conformationally restricted benzoxepin type combretastatin analogs: synthesis, antiproliferative activity, and tubulin effects.Synthesis, biological evaluation, structural-activity relationship, and docking study for a series of benzoxepin-derived estrogen receptor modulators.Benzothiepin-derived molecular scaffolds for estrogen receptor modulators: synthesis and antagonistic effects in breast cancer cells.Flexible estrogen receptor modulators: synthesis, biochemistry and molecular modeling studies for 3-benzyl-4,6-diarylhex-3-ene and 3,4,6-triarylhex-3-ene derivatives.Synthesis, structure-activity relationships and antagonistic effects in human MCF-7 breast cancer cells of flexible estrogen receptor modulators.Structure-activity studies with high-affinity inhibitors of pyroglutamyl-peptidase II.A topological study of prodrugs of 5-fluorouracil.Approaches to Scaffold Hopping.Scaffold hopping in de novo design. Ligand generation in the absence of receptor information.The effect of tightly bound water molecules on the structural interpretation of ligand-derived pharmacophore models.Cell volume control in phospholemman (PLM) knockout mice: do cardiac myocytes demonstrate a regulatory volume decrease and is this influenced by deletion of PLM?Structure-activity relationships in non-ligand binding pocket (non-LBP) diarylhydrazide antiandrogens.Screening for inhibitors of tau protein aggregation into Alzheimer paired helical filaments: a ligand based approach results in successful scaffold hopping.Development of the β-lactam type molecular scaffold for selective estrogen receptor α modulator action: synthesis and cytotoxic effects in MCF-7 breast cancer cells.Permuting input for more effective sampling of 3D conformer space.Considerations in compound database preparation--"hidden" impact on virtual screening results.Study of E/Z isomerization in a series of novel non-ligand binding pocket androgen receptor antagonists.Design, Synthesis and Biochemical Evaluation of Novel Selective Estrogen Receptor Ligand Conjugates Incorporating an Endoxifen-Combretastatin Hybrid Scaffold.On the effects of permuted input on conformational sampling of drug-like molecules: an evaluation of stochastic proximity embedding.'tieredScreen' - Layered Virtual Screening Tool for the Identification of Novel Estrogen Receptor Alpha Modulators.Theoretical studies of parent 1-, 2-, 3-pyrazolines and their methylated derivativesUnbiasing scoring functions: a new normalization and rescoring strategy
P50
Q33236308-35DB0BCF-9EF0-44C6-86B5-5A9F56BF7D5CQ33498288-58119643-3A2C-4DB8-8BF5-5CB0EFB87D4FQ33512310-41C57BCA-744D-4091-AD4E-0BF30F293FD8Q33885466-FB869ECF-BF42-49DF-803C-E83CCBBF5FBAQ34150086-B7C0794F-6F51-400B-A62B-71A8EEA53DE4Q34216670-8C2D64A2-16F3-48B1-8E4A-44D96769869AQ34300660-16FFD5D8-E673-4D6A-B6DF-67D8FD42F4F2Q34342378-1BCEC47F-D865-426A-AE74-B3B32199D47BQ34619281-E187F061-23BD-473E-A1B5-45B115204810Q35261723-1127E4F7-F065-4EB5-8406-F5EAB253A2F8Q35435019-9B4C8E4D-76B8-4DFC-9000-EBCA211254FFQ36091230-21E5E4F7-BDA8-42B3-B91B-24CBB05A29BAQ38076345-E015DFDE-BEAB-49D3-AF93-EFB6EB4233BCQ38991956-C142E11D-8331-4541-8F98-D42E104974C5Q39490537-518EC26C-55C4-4EF9-AA19-089AD81FED21Q39577197-DD68F18E-E24F-403E-965B-5DA4556D9B76Q39646476-E4F06F7F-0D46-4A50-9904-1266A08ACAC5Q39668887-FE9B2EB1-ED1B-420E-891D-5E739ED3B572Q39728931-298C58DA-0934-48C1-8C3D-8EBD458BA71AQ39932658-53C33B49-7C28-4499-8B60-7CCD4A6944A0Q40045511-32CD42FA-36BC-4511-871D-76F1A726EFB7Q40161324-F8515AF9-37D1-4792-AA2E-394C8EE30042Q40264576-FEA71C80-0523-4B4F-BC17-75A629114382Q42920341-8E850CBF-97B1-48EC-8B34-A1C135595D2FQ43832635-082F4F6E-CD83-49C6-93FA-9F0B732BE1BFQ44376091-25BAF32D-C458-4A52-9038-34B99D9F6F4EQ44736841-F8BF6987-29FC-48A8-AE57-751F2E6D66CEQ45002480-358A2A88-5E26-44B0-9D27-03B27B90EC4DQ46202348-FF545C5C-0E1E-421D-8289-07F69D4469B6Q46249101-0B10E2A2-E0B7-41C1-AE2A-2A05B6004C7AQ48107071-2AADEAE4-7590-47B8-9171-D629DC9E67C5Q51604002-AA75C716-26D4-4CB1-965F-1650302C2C53Q51937689-6F8F7574-8EC6-4D2C-8B7F-659E31664004Q51959360-ED1B6483-77BF-4B2A-941E-4DC64A2BB968Q52628207-AD65AD13-D273-4E29-A12F-4BFFE3325A0DQ52769257-D50E1801-9837-4EEE-8A54-0CD538D33683Q53025802-1F97AC8B-A37D-4AB8-B144-2457EFAF466BQ53938693-CA098FE5-4016-4215-B827-DFC827A27836Q64028368-A8B95299-7D8B-4912-A3D1-C291A59E6EC1Q80437437-DA0625AB-E299-4025-B87E-876CB8677295
P50
description
Irish chemist (1974)
@en
wetenschapper
@nl
name
David Lloyd
@ast
David Lloyd
@en
David Lloyd
@es
David Lloyd
@nl
David Lloyd
@sl
type
label
David Lloyd
@ast
David Lloyd
@en
David Lloyd
@es
David Lloyd
@nl
David Lloyd
@sl
altLabel
David G. Lloyd
@en
David G. Lloyd
@nl
David G. Lloyd
@sl
David George Lloyd
@en
prefLabel
David Lloyd
@ast
David Lloyd
@en
David Lloyd
@es
David Lloyd
@nl
David Lloyd
@sl
P106
P1053
E-9152-2013
P1153
27867891200
P19
P21
P27
P31
P3829
P496
0000-0003-0658-8995
P569
1974-04-25T00:00:00Z