Insights into Coupled Folding and Binding Mechanisms from Kinetic Studies
about
The contribution of intrinsically disordered regions to protein function, cellular complexity, and human diseaseIntrinsic Disorder in Transmembrane Proteins: Roles in Signaling and Topology Prediction.Conserved Helix-Flanking Prolines Modulate Intrinsically Disordered Protein:Target Affinity by Altering the Lifetime of the Bound ComplexDissecting mechanism of coupled folding and binding of an intrinsically disordered protein by chemical synthesis of conformationally constrained analogues.Site-Specific Polymer Attachment to HR2 Peptide Fusion Inhibitors against HIV-1 Decreases Binding Association Rates and Dissociation Rates Rather Than Binding Affinity.Order-Disorder Transitions in the Cardiac Troponin Complex.Kinetic Insights into the Binding between the nSH3 Domain of CrkII and Proline-Rich Motifs in cAblIntrinsic protein disorder in oncogenic KRAS signaling.Trehalose induces functionally active conformation in the intrinsically disordered N-terminal domain of glucocorticoid receptor.Unveiling the folding mechanism of the Bromodomains.Time-course, negative-stain electron microscopy-based analysis for investigating protein-protein interactions at the single-molecule level.Introduction to the Thematic Minireview Series on Intrinsically Disordered Proteins.Slow molecular recognition by RNA.A histone-mimicking interdomain linker in a multidomain protein modulates multivalent histone binding.Unified understanding of folding and binding mechanisms of globular and intrinsically disordered proteins.pKID Binds to KIX via an Unstructured Transition State with Nonnative Interactions.Phosphorylation of the IDP KID Modulates Affinity for KIX by Increasing the Lifetime of the Complex.Recognition by host nuclear transport proteins drives disorder-to-order transition in Hendra virus V.Dynamic Modulation of Binding Affinity as a Mechanism for Regulating Interferon Signaling.Enhanced Sampling of Intrinsic Structural Heterogeneity of the BH3-Only Protein Binding Interface of Bcl-xL.Affinity of IDPs to their targets is modulated by ion-specific changes in kinetics and residual structure.Rapid Microfluidic Dilution for Single-Molecule Spectroscopy of Low-Affinity Biomolecular Complexes.The functional roles of the unstructured N- and C-terminal regions in αB-crystallin and other mammalian small heat-shock proteins.Disparate binding kinetics by an intrinsically disordered domain enables temporal regulation of transcriptional complex formation.Molecular Mechanisms of Tight Binding through Fuzzy Interactions.Folding and binding pathways of BH3-only proteins are encoded within their intrinsically disordered sequence, not templated by partner proteins.Conservation of coactivator engagement mechanism enables small-molecule allosteric modulatorsTransition path times of coupled folding and binding reveal the formation of an encounter complexA proline switch explains kinetic heterogeneity in a coupled folding and binding reactionRapid Microfluidic Dilution for Single-Molecule Spectroscopy of Low-Affinity Biomolecular Complexes
P2860
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P2860
Insights into Coupled Folding and Binding Mechanisms from Kinetic Studies
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2016 nî lūn-bûn
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2016 թուականի Մարտին հրատարակուած գիտական յօդուած
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2016 թվականի մարտին հրատարակված գիտական հոդված
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2016年の論文
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2016年学术文章
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2016年学术文章
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2016年学术文章
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2016年学术文章
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2016年学术文章
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2016年學術文章
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name
Insights into Coupled Folding and Binding Mechanisms from Kinetic Studies
@ast
Insights into Coupled Folding and Binding Mechanisms from Kinetic Studies
@en
Insights into Coupled Folding and Binding Mechanisms from Kinetic Studies
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type
label
Insights into Coupled Folding and Binding Mechanisms from Kinetic Studies
@ast
Insights into Coupled Folding and Binding Mechanisms from Kinetic Studies
@en
Insights into Coupled Folding and Binding Mechanisms from Kinetic Studies
@nl
prefLabel
Insights into Coupled Folding and Binding Mechanisms from Kinetic Studies
@ast
Insights into Coupled Folding and Binding Mechanisms from Kinetic Studies
@en
Insights into Coupled Folding and Binding Mechanisms from Kinetic Studies
@nl
P2093
P2860
P921
P3181
P356
P1476
Insights into Coupled Folding and Binding Mechanisms from Kinetic Studies
@en
P2093
Basile I M Wicky
Jane Clarke
Liza Dahal
P2860
P304
P3181
P356
10.1074/JBC.R115.692715
P407
P577
2016-02-05T00:00:00Z