The prion protein unstructured N-terminal region is a broad-spectrum molecular sensor with diverse and contrasting potential functions
about
The Cellular Prion Protein: A Player in Immunological QuiescenceNeurodegeneration and unfolded-protein response in mice expressing a membrane-tethered flexible tail of PrPUnique drug screening approach for prion diseases identifies tacrolimus and astemizole as antiprion agentsBiochemical insight into the prion protein family.Evidence for synergistic effects of PRNP and ATP7B mutations in severe neuropsychiatric deterioration.Octarepeat region flexibility impacts prion function, endoproteolysis and disease manifestationThermodynamic characterization of the unfolding of the prion protein.Peripheral administration of a humanized anti-PrP antibody blocks Alzheimer's disease Aβ synaptotoxicity.The P's and Q's of cellular PrP-Aβ interactionsProteolytic processing of the prion protein in health and disease.Regulation of PrP(C) signaling and processing by dimerization.Melanin or a Melanin-Like Substance Interacts with the N-Terminal Portion of Prion Protein and Inhibits Abnormal Prion Protein Formation in Prion-Infected Cells.The prion protein is critical for DNA repair and cell survival after genotoxic stress.Homodimerization as a molecular switch between low and high efficiency PrP C cell surface delivery and neuroprotective activity.Domain-Specific Activation of Death-Associated Intracellular Signalling Cascades by the Cellular Prion Protein in Neuroblastoma Cells.Soluble Aβ aggregates can inhibit prion propagation.Structural and mechanistic aspects influencing the ADAM10-mediated shedding of the prion protein.Alterations in the brain interactome of the intrinsically disordered N-terminal domain of the cellular prion protein (PrPC) in Alzheimer's disease.
P2860
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P2860
The prion protein unstructured N-terminal region is a broad-spectrum molecular sensor with diverse and contrasting potential functions
description
2012 nî lūn-bûn
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2012 թուականի Մարտին հրատարակուած գիտական յօդուած
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2012 թվականի մարտին հրատարակված գիտական հոդված
@hy
2012年の論文
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2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
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2012年论文
@wuu
name
The prion protein unstructured ...... ontrasting potential functions
@ast
The prion protein unstructured ...... ontrasting potential functions
@en
The prion protein unstructured ...... ontrasting potential functions
@nl
type
label
The prion protein unstructured ...... ontrasting potential functions
@ast
The prion protein unstructured ...... ontrasting potential functions
@en
The prion protein unstructured ...... ontrasting potential functions
@nl
prefLabel
The prion protein unstructured ...... ontrasting potential functions
@ast
The prion protein unstructured ...... ontrasting potential functions
@en
The prion protein unstructured ...... ontrasting potential functions
@nl
P1476
The prion protein unstructured ...... ontrasting potential functions
@en
P2093
Maxime Béland
Xavier Roucou
P304
P356
10.1111/J.1471-4159.2011.07613.X
P407
P577
2012-03-01T00:00:00Z