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Molecular pathogenesis of multiple myeloma: basic and clinical updates

Molecular pathogenesis of multiple myeloma: basic and clinical updates

http://www.wikidata.org/entity/Q27026205

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First line vs delayed transplantation in myeloma: Certainties and controversies A novel phthalimide derivative, TC11, has preclinical effects on high-risk myeloma cells and osteoclasts Advances in understanding prognosis in myeloma.Direct inhibition of c-Myc-Max heterodimers by celastrol and celastrol-inspired triterpenoids.Genetic interrogation of circulating multiple myeloma cells at single-cell resolution.Targeting Ongoing DNA Damage in Multiple Myeloma: Effects of DNA Damage Response Inhibitors on Plasma Cell Survival.MicroRNA: important player in the pathobiology of multiple myeloma Efficient transient transfection of human multiple myeloma cells by electroporation--an appraisal.Rational combination treatment with histone deacetylase inhibitors and immunomodulatory drugs in multiple myeloma.Genome-wide pharmacologic unmasking identifies tumor suppressive microRNAs in multiple myeloma.Dexamethasone-induced cell death is restricted to specific molecular subgroups of multiple myeloma.Gamabufotalin triggers c-Myc degradation via induction of WWP2 in multiple myeloma cells.BRAFV600 mutations in solid tumors, other than metastatic melanoma and papillary thyroid cancer, or multiple myeloma: a screening study.Co-targeting translation and proteasome rapidly kills colon cancer cells with mutant RAS/RAF via ER stress.Mechanisms of oncogenic chromosomal translocations.The impact of intra-clonal heterogeneity on the treatment of multiple myeloma.MicroRNA-21 and multiple myeloma: small molecule and big function.Prognostic indicators of lenalidomide for multiple myeloma: consensus and controversy.Microvesicles derived from normal and multiple myeloma bone marrow mesenchymal stem cells differentially modulate myeloma cells' phenotype and translation initiation.Cyclin D1 unbalances the redox status controlling cell adhesion, migration, and drug resistance in myeloma cells.Genomewide association study on monoclonal gammopathy of unknown significance (MGUS).Multiple myeloma cells alter the senescence phenotype of bone marrow mesenchymal stromal cells under participation of the DLK1-DIO3 genomic region.Epigenetic mechanisms of cell adhesion-mediated drug resistance in multiple myeloma.Curcumin induces cell death of the main molecular myeloma subtypes, particularly the poor prognosis subgroups.Clinical Pharmacokinetics of Vemurafenib.p53-related protein kinase confers poor prognosis and represents a novel therapeutic target in multiple myeloma.PREVENTING THE CHROMOSOMAL TRANSLOCATIONS THAT CAUSE CANCER Modifications of the mouse bone marrow microenvironment favor angiogenesis and correlate with disease progression from asymptomatic to symptomatic multiple myeloma.Recurrent alterations of the WW domain containing oxidoreductase gene spanning the common fragile site FRA16D in multiple myeloma and monoclonal gammopathy of undetermined significance.Impact of C-Myc gene-related aberrations in newly diagnosed myeloma with bortezomib/dexamethasone therapy.Using digital polymerase chain reaction to detect minimal residual disease in myeloma by identifying FGFR3 up-regulation.The therapeutic potential of cell cycle targeting in multiple myeloma.Bortezomib overcomes the negative prognostic impact of renal impairment in a newly diagnosed elderly patient with multiple myeloma: A case report.The Utilization of Karyotyping, iFISH, and MLPA for the Detection of Recurrence Genetic Aberrations in Multiple Myeloma Abdominal subcutaneous fat pad aspiration and bone marrow examination for the diagnosis of AL amyloidosis: the reliability of immunohistochemistry.MicroRNA-19a functions as an oncogene by regulating PTEN/AKT/pAKT pathway in myeloma.The selectivity of Marinopyrrole A to induce apoptosis in MCL1high BCL2low expressing myeloma cells is related to its ability to impair protein translation.HIF-2α-ILK Is Involved in Mesenchymal Stromal Cell Angiogenesis in Multiple Myeloma Under Hypoxic Conditions.A novel nano-immunoassay method for quantification of proteins from CD138-purified myeloma cells: biological and clinical utility.PAX5-positive plasma cell myeloma with t(9;14;11)(p13;q32;q13), a novel complex variant translocation of t(11;14)(q13;q32) and t(9;14)(p13;q32).

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Molecular pathogenesis of multiple myeloma: basic and clinical updates

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2013 nî lūn-bûn

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Molecular pathogenesis of multiple myeloma: basic and clinical updates

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International Journal of Hematology

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Molecular pathogenesis of multiple myeloma: basic and clinical updates

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Marta Chesi

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P. Leif Bergsagel

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Downregulation of p53-inducible microRNAs 192, 194, and 215 impairs the p53/MDM2 autoregulatory loop in multiple myeloma development

Initial genome sequencing and analysis of multiple myeloma

Prognostic significance of copy-number alterations in multiple myeloma

Monoclonal gammopathy of undetermined significance (MGUS) consistently precedes multiple myeloma: a prospective study

MicroRNAs regulate critical genes associated with multiple myeloma pathogenesis

Antibody-based targeting of FGFR3 in bladder carcinoma and t(4;14)-positive multiple myeloma in mice

Clinical and biological significance of RAS mutations in multiple myeloma.

Cancer statistics, 2013

Chromosome translocations in multiple myeloma

BET bromodomain inhibition as a therapeutic strategy to target c-Myc

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