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Huntington's disease: underlying molecular mechanisms and emerging concepts

Huntington's disease: underlying molecular mechanisms and emerging concepts

http://www.wikidata.org/entity/Q27026255

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A dynamic interface between ubiquitylation and cAMP signaling Role of NMDA Receptor-Mediated Glutamatergic Signaling in Chronic and Acute Neuropathologies Large-scale microfluidics providing high-resolution and high-throughput screening of Caenorhabditis elegans poly-glutamine aggregation model.Polyglutamine toxicity in yeast induces metabolic alterations and mitochondrial defects Roles of tau protein in health and disease.Phosphodiesterase Inhibitors as a Therapeutic Approach to Neuroprotection and Repair.Biophysical underpinnings of the repeat length dependence of polyglutamine amyloid formation Laquinimod treatment in the R6/2 mouse model.Coexpression within Integrated Mitochondrial Pathways Reveals Different Networks in Normal and Chemically Treated Transcriptomes.Assemblages: functional units formed by cellular phase separation Skeletal muscle pathology in Huntington's disease Protein aggregation can inhibit clathrin-mediated endocytosis by chaperone competition.A common gene expression signature in Huntington's disease patient brain regions.The biology of proteostasis in aging and disease.Repeat associated non-ATG (RAN) translation: new starts in microsatellite expansion disorders.Prevalent polymorphism in thyroid hormone-activating enzyme leaves a genetic fingerprint that underlies associated clinical syndromes Reduced Levels of Proteasome Products in a Mouse Striatal Cell Model of Huntington's Disease.Folding Landscape of Mutant Huntingtin Exon1: Diffusible Multimers, Oligomers and Fibrils, and No Detectable Monomer.The Spectrum of Psychiatric Pathology in a Patient with Genetically Verified Huntington's Disease.Impaired GAPDH-induced mitophagy contributes to the pathology of Huntington's disease.Beyond the redox imbalance: Oxidative stress contributes to an impaired GLUT3 modulation in Huntington's disease Effects of Pin1 Loss in Hdh(Q111) Knock-in Mice.Abnormal Weight and Body Mass Index in Children with Juvenile Huntington's Disease.αB-Crystallin overexpression in astrocytes modulates the phenotype of the BACHD mouse model of Huntington's disease Repeat-associated non-ATG (RAN) translation in neurological disease.Glycation potentiates neurodegeneration in models of Huntington's disease.miRNAs: Key Players in Neurodegenerative Disorders and Epilepsy Contribution of Neuroepigenetics to Huntington's Disease.Emerging Synaptic Molecules as Candidates in the Etiology of Neurological Disorders.Aggregation of scaffolding protein DISC1 dysregulates phosphodiesterase 4 in Huntington's disease Targeting CAG repeat RNAs reduces Huntington's disease phenotype independently of huntingtin levels.Insights on the interaction of alpha-synuclein and metals in the pathophysiology of Parkinson's disease.Anti-amyloid compounds protect from silica nanoparticle-induced neurotoxicity in the nematode C. elegans.AMPK-mediated regulation of neuronal metabolism and function in brain diseases.Exosomes and Homeostatic Synaptic Plasticity Are Linked to Each other and to Huntington's, Parkinson's, and Other Neurodegenerative Diseases by Database-Enabled Analyses of Comprehensively Curated Datasets.Genetic Approaches to Understanding Psychiatric Disease.Huntington's disease: Molecular basis of pathology and status of current therapeutic approaches Modulation of Molecular Chaperones in Huntington's Disease and Other Polyglutamine Disorders.Group I Metabotropic Glutamate Receptor Interacting Proteins: Fine-Tuning Receptor Functions in Health and Disease.RNA toxicity induced by expanded CAG repeats in Huntington's disease.

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Huntington's disease: underlying molecular mechanisms and emerging concepts

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2013 nî lūn-bûn

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2013 թուականի Օգոստոսին հրատարակուած գիտական յօդուած

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2013 թվականի օգոստոսին հրատարակված գիտական հոդված

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2013年の論文

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2013年論文

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Huntington's disease: underlying molecular mechanisms and emerging concepts

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Trends in Biochemical Sciences

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Huntington's disease: underlying molecular mechanisms and emerging concepts

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John Labbadia

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Richard I. Morimoto

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P2860

The importance of integrating basic and clinical research toward the development of new therapies for Huntington disease

Rhes, a striatal specific protein, mediates mutant-huntingtin cytotoxicity

Cytoplasmic penetration and persistent infection of mammalian cells by polyglutamine aggregates

Heat shock transcription factor 1 as a therapeutic target in neurodegenerative diseases

Destabilizing protein polymorphisms in the genetic background direct phenotypic expression of mutant SOD1 toxicity

Adapting proteostasis for disease intervention

The kynurenine pathway modulates neurodegeneration in a Drosophila model of Huntington's disease

Formation of neuronal intranuclear inclusions underlies the neurological dysfunction in mice transgenic for the HD mutation

Shaping the role of mitochondria in the pathogenesis of Huntington's disease

Reversal of neuropathology and motor dysfunction in a conditional model of Huntington's disease

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Huntington disease

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