about
sameAs
Interleukin-6 secretion by astrocytes is dynamically regulated by PI3K-mTOR-calcium signalingmTOR kinase structure, mechanism and regulationmTORC1 and JNK coordinate phosphorylation of the p70S6K1 autoinhibitory domain in skeletal muscle following functional overloading.Torin2 targets dysregulated pathways in anaplastic thyroid cancer and inhibits tumor growth and metastasis.Dual Targeting of mTOR Activity with Torin2 Potentiates Anticancer Effects of Cisplatin in Epithelial Ovarian CancerTorin2 Potentiates Anticancer Effects on Adult T-Cell Leukemia/Lymphoma by Inhibiting Mammalian Target of Rapamycin.Activity of the novel mTOR inhibitor Torin-2 in B-precursor acute lymphoblastic leukemia and its therapeutic potential to prevent Akt reactivation.Characterization of Torin2, an ATP-competitive inhibitor of mTOR, ATM, and ATR.High prevalence of mTOR complex activity can be targeted using Torin2 in papillary thyroid carcinoma.Inactivation of mTor arrests bovine oocytes in the metaphase-I stage, despite reversible inhibition of 4E-BP1 phosphorylation.The novel mTOR inhibitor Torin-2 induces autophagy and downregulates the expression of UHRF1 to suppress hepatocarcinoma cell growth.
P921
Q27313777-64E6DD76-8EB5-4706-8C53-B241D77C80ABQ27677954-3EEBBA24-03B5-42F5-94A5-C898CA5848E8Q33764652-7E5E9283-46B3-45F2-A7D0-7D29F9A4E932Q35623044-250BFAF7-839F-4F2F-B74E-2DE6D59E14D3Q36167088-1BDC8CD7-9AE9-4E38-B97C-2ED557C0DB27Q38807341-38A074B0-248B-4FD2-B870-19059DFCA27AQ38949674-FD16D080-5BA1-4731-989E-CB3F66BFD231Q39189263-2740CBBE-A447-4C63-9C6F-8D5300E404FBQ46952217-976BADF3-182E-4E2A-A588-D873A40B9BB0Q48609783-B5AA49D3-C384-41B2-B0BB-9DB64ECD8148Q52926712-9CFB4F8D-C21E-496D-BCF3-E57E317ED856
P921
description
chemesch Verbindung
@lb
chemical compound
@en
chemical compound
@en-ca
chemical compound
@en-gb
chemická sloučenina
@cs
chemická zlúčenina
@sk
chemiese verbinding
@af
chemische Verbindung
@de
chemische Verbindung
@de-ch
chemische verbinding
@nl
name
torin 2
@en
type
label
torin 2
@en
altLabel
9-(6-Amino-3-pyridinyl)-1-[3-(trifluoromethyl)phenyl]benzo[h]-1,6-naphthyridin-2(1H)-one
@en
Torin 2
@en
Torin-2
@en
compound 3
@en
torin2
@en
prefLabel
torin 2
@en
P592
P638
P661
P662
P683
P1579
P2067
P231
1223001-51-1
P233
C1=CC(=CC(=C1)N2C(=O)C=CC3=CN=C4C=CC(=CC4=C32)C5=CN=C(C=C5)N)C(F)(F)F
P234
1S/C24H15F3N4O/c25-24(26,27)17 ...... (28)30-12-15/h1-13H,(H2,28,30)
P235
GUXXEUUYCAYESJ-UHFFFAOYSA-N
P274
C₂₄H₁₅F₃N₄O
P3117
DTXSID00679917
P592
CHEMBL1765602