Effects of suberoylanilide hydroxamic acid and trichostatin A on induction of cytochrome P450 enzymes and benzo[a]pyrene DNA adduct formation in human cellsDiscovery of novel alpha7 nicotinic receptor antagonistsThe use of dioxygen by HIF prolyl hydroxylase (PHD1)Benzoxazole benzenesulfonamides are novel allosteric inhibitors of fructose-1,6-bisphosphatase with a distinct binding modeA new class of 5-HT2B antagonists possesses favorable potency, selectivity, and rat pharmacokinetic propertiesIdentification and optimization of N3,N6-diaryl-1H-pyrazolo[3,4-d]pyrimidine-3,6-diamines as a novel class of ACK1 inhibitorsAllosteric FBPase inhibitors gain 10(5) times in potency when simultaneously binding two neighboring AMP sitesStructure-based design of 2-arylamino-4-cyclohexylmethyl-5-nitroso-6-aminopyrimidine inhibitors of cyclin-dependent kinases 1 and 2Design of selective phenylglycine amide tissue factor/factor VIIa inhibitorsIdentification of (R)-N-(4-(4-methoxyphenyl)thiazol-2-yl)-1-tosylpiperidine-2-carboxamide, ML277, as a novel, potent and selective K(v)7.1 (KCNQ1) potassium channel activatorMethoxy-substituted 9-aminomethyl-9,10-dihydroanthracene (AMDA) derivatives exhibit differential binding affinities at the 5-HT(2A) receptor9-Aminomethyl-9,10-dihydroanthracene (AMDA) analogs as structural probes for steric tolerance in 5-HT2A and H1 receptor binding sitesPositive allosteric modulators of the metabotropic glutamate receptor subtype 4 (mGluR4). Part II: Challenges in hit-to-leadDiscovery, design and synthesis of novel potent and selective sphingosine-1-phosphate 4 receptor (S1P₄-R) agonistsDiscovery, synthesis and SAR analysis of novel selective small molecule S1P4-R agonists based on a (2Z,5Z)-5-((pyrrol-3-yl)methylene)-3-alkyl-2-(alkylimino)thiazolidin-4-one chemotypeChemical lead optimization of a pan Gq mAChR M1, M3, M5 positive allosteric modulator (PAM) lead. Part II: development of a potent and highly selective M1 PAMSynthesis of desformylflustrabromine and its evaluation as an alpha4beta2 and alpha7 nACh receptor modulatorSyntheses of novel high affinity ligands for opioid receptorsSyntheses and optimization of new GS39783 analogues as positive allosteric modulators of GABA B receptorsDesign, synthesis, and evaluation of novel ethambutol analogues(+/-)-Nantenine analogs as antagonists at human 5-HT(2A) receptors: C1 and flexible congenersSelectivity of inhibitors of endocannabinoid biosynthesis evaluated by activity-based protein profilingRedefining the structure-activity relationships of 2,6-methano-3-benzazocines. 5. Opioid receptor binding properties of N-((4'-phenyl)-phenethyl) analogues of 8-CACSynthesis and evaluation of febrifugine analogues as potential antimalarial agentsSynthetic studies of neoclerodane diterpenes from Salvia divinorum: exploration of the 1-positionAnalogues of the dopamine D2 receptor antagonist L741,626: Binding, function, and SARDirected molecular screening for RecA ATPase inhibitorsDiscovery of heterobicyclic templates for novel metabotropic glutamate receptor subtype 5 antagonistsNeutrophil elastase inhibitors for the treatment of (cardio)pulmonary diseases: Into clinical testing with pre-adaptive pharmacophoresIsotope chemistry; a useful tool in the drug discovery arsenalTarget engagement in lead generationDesign of small molecule epigenetic modulatorsConceptual and technical aspects of transfection and gene deliveryRecent progress and future options in the development of GLP-1 receptor agonists for the treatment of diabesityMale contraception: another Holy GrailA medicinal chemists' guide to the unique difficulties of lead optimization for tuberculosisFuture directions in phosphodiesterase drug discoveryConfronting the challenges of discovery of novel antibacterial agentsAmino acidic scaffolds bearing unnatural side chains: an old idea generates new and versatile tools for the life sciencesRecent advances in malaria drug discovery
P1433
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P1433
description
begutachtete wissenschaftliche Fachzeitschrift
@de
peer-reviewed scientific journal
@en
revista científica
@es
revue scientifique
@fr
rivista scientifica
@it
vědecký časopis
@cs
wetenschappelijk tijdschrift van Elsevier
@nl
рецензований науковий журнал
@uk
वैज्ञानिक पत्रिका
@hi
name
Bioorganic & Medicinal Chemistry Letters
@ast
Bioorganic & Medicinal Chemistry Letters
@da
Bioorganic & Medicinal Chemistry Letters
@de
Bioorganic & Medicinal Chemistry Letters
@en
Bioorganic & Medicinal Chemistry Letters
@es
Bioorganic & Medicinal Chemistry Letters
@fi
Bioorganic & Medicinal Chemistry Letters
@fo
Bioorganic & Medicinal Chemistry Letters
@fr
Bioorganic & Medicinal Chemistry Letters
@is
Bioorganic & Medicinal Chemistry Letters
@it
type
label
Bioorganic & Medicinal Chemistry Letters
@ast
Bioorganic & Medicinal Chemistry Letters
@da
Bioorganic & Medicinal Chemistry Letters
@de
Bioorganic & Medicinal Chemistry Letters
@en
Bioorganic & Medicinal Chemistry Letters
@es
Bioorganic & Medicinal Chemistry Letters
@fi
Bioorganic & Medicinal Chemistry Letters
@fo
Bioorganic & Medicinal Chemistry Letters
@fr
Bioorganic & Medicinal Chemistry Letters
@is
Bioorganic & Medicinal Chemistry Letters
@it
altLabel
Bioorg Med Chem Lett
@da
Bioorg Med Chem Lett
@de
Bioorg Med Chem Lett
@en
Bioorganic and Medicinal Chemistry Letters
@fr
prefLabel
Bioorganic & Medicinal Chemistry Letters
@ast
Bioorganic & Medicinal Chemistry Letters
@da
Bioorganic & Medicinal Chemistry Letters
@de
Bioorganic & Medicinal Chemistry Letters
@en
Bioorganic & Medicinal Chemistry Letters
@es
Bioorganic & Medicinal Chemistry Letters
@fi
Bioorganic & Medicinal Chemistry Letters
@fo
Bioorganic & Medicinal Chemistry Letters
@fr
Bioorganic & Medicinal Chemistry Letters
@is
Bioorganic & Medicinal Chemistry Letters
@it
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P1813
Bioorg Med Chem Lett
@en
P236
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P5963
bioorganic-and-medicinal-chemistry-letters