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A novel 21-kDa cytochrome c-releasing factor is generated upon treatment of human leukemia U937 cells with geranylgeraniolRoles of rat and human aldo-keto reductases in metabolism of farnesol and geranylgeraniolHydrogenation of geranylgeraniol : two pathways exist in spinach chloroplastsBrain cholesterol turnover required for geranylgeraniol production and learning in mice.Antinociceptive effect of geranylgeraniol and 6alpha,7beta-dihydroxyvouacapan-17beta-oate methyl ester isolated from Pterodon pubescens Benth.Geranylgeraniol suppresses the viability of human DU145 prostate carcinoma cells and the level of HMG CoA reductaseRapid identification of cysteine-linked isoprenyl groups by metabolic labeling with [3H]farnesol and [3H]geranylgeraniol.Dietary geranylgeraniol can limit the activity of pitavastatin as a potential treatment for drug-resistant ovarian cancerScreening of terpenes and derivatives for antimycobacterial activity; identification of geranylgeraniol and geranylgeranyl acetate as potent inhibitors of Mycobacterium tuberculosis in vitro.Alendronate mechanism of action: geranylgeraniol, an intermediate in the mevalonate pathway, prevents inhibition of osteoclast formation, bone resorption, and kinase activation in vitro.The prenyltransferase UBIAD1 is the target of geranylgeraniol in degradation of HMG CoA reductaseBiphasic requirement for geranylgeraniol in hippocampal long-term potentiationSufficient production of geranylgeraniol is required to maintain endotoxin tolerance in macrophages.Characterization of an FMO variant of Chlorobaculum tepidum carrying bacteriochlorophyll a esterified by geranylgeraniol.Acyclic diterpene alcohols: occurrence and synthesis of geranylcitronellol, phytol and geranylgeraniol.Synergistic Impact of d-δ-Tocotrienol and Geranylgeraniol on the Growth and HMG CoA Reductase of Human DU145 Prostate Carcinoma Cells.Geranylgeraniol and Neurological Impairment: Involvement of Apoptosis and Mitochondrial Morphology.Geranylgeraniol enhances testosterone production via the cAMP/protein kinase A pathway in testis-derived I-10 tumor cells.Antileishmanial activity of the essential oil from Bixa orellana.Lovastatin-induced apoptosis is modulated by geranylgeraniol in a neuroblastoma cell line.Inhibition of neuronal cholesterol biosynthesis with lovastatin leads to impaired synaptic vesicle release even in the presence of lipoproteins or geranylgeraniol.Geranylgeraniol prevents the cytotoxic effects of mevastatin in THP-1 cells, without decreasing the beneficial effects on cholesterol synthesis.Plaunotol and geranylgeraniol induce caspase-mediated apoptosis in colon cancer.Vitamin K2 and geranylgeraniol, its side chain component, inhibited osteoclast formation in a different manner.Farnesol and geranylgeraniol prevent activation of caspases by aminobisphosphonates: biochemical evidence for two distinct pharmacological classes of bisphosphonate drugs.Novel salvage pathway utilizing farnesol and geranylgeraniol for protein isoprenylation.Induction of apoptosis in various tumor cell lines by geranylgeraniol.Geranylgeraniol restores cell proliferation to lovastatin treated C6 glial cells.Biphasic effects of geranylgeraniol, teprenone, and phytol on the growth of Staphylococcus aureus.Overproduction of geranylgeraniol by metabolically engineered Saccharomyces cerevisiae.Mitochondria Superoxide Anion Production Contributes to Geranylgeraniol-Induced Death in Leishmania amazonensisGeranylgeraniol potentiates lovastatin inhibition of oncogenic H-Ras processing and signaling while preventing cytotoxicity.Identification and characterization of geranylgeraniol kinase and geranylgeranyl phosphate kinase from the Archaebacterium Sulfolobus acidocaldarius.Molecular genetic analysis of terminal steps in bacteriochlorophyll a biosynthesis: characterization of a Rhodobacter capsulatus strain that synthesizes geranylgeraniol-esterified bacteriochlorophyll a.Mevalonate depletion mediates the suppressive impact of geranylgeraniol on murine B16 melanoma cells.Farnesol and geranylgeraniol: prevention and reversion of lovastatin-induced effects in NIH3T3 cells.Dolichols, ubiquinones, geranylgeraniol and farnesol as the major metabolites of mevalonate in Phytophthora cactorum.Production of geranylgeraniol on overexpression of a prenyl diphosphate synthase fusion gene in Saccharomyces cerevisiae.Dietary supplementation with geranylgeraniol suppresses lipopolysaccharide-induced inflammation via inhibition of nuclear factor-κB activation in rats.Geranylgeraniol, an intermediate product in mevalonate pathway, induces apoptotic cell death in human hepatoma cells: death receptor-independent activation of caspase-8 with down-regulation of Bcl-xL expression.
P921
Q24293188-0660D2F2-FAD3-435E-926B-1B831E45385EQ24321475-72AE21A1-ED68-4642-AF5C-299A8BEE536AQ24520392-CD72BBA8-6BD4-4BD9-9564-3AF48DB5422FQ30477204-F1CC33EC-5C57-4F74-B0A4-E1BD9D25BB2DQ33522472-1F5467E1-C3B4-4A1D-A744-9E28315045EFQ33566667-B50B709D-EA37-47DF-9CE1-EC93DCF27966Q33566667-FC912ADB-7767-4371-BBE4-6C772A68115AQ33683515-02E2B290-29F5-452F-82A8-47F01F49882FQ33906118-095D0323-66A2-4881-A351-F411D6529734Q34699704-DD4457D1-36CD-4F1A-A34D-67292BF890B4Q34793691-836AE546-A693-4ABC-90F4-C98C96EDD111Q35218996-DB70C9A6-3539-4B19-918C-93A752E33701Q36837419-92D7174E-0E20-4F40-95BF-7F82D332F067Q37305397-BE6124BF-F42A-4016-9ABE-20AE47283971Q37638565-0ECE4BF6-4169-446F-8377-E1A955DEFEE0Q38593406-8B8D278F-173A-496E-AD22-0AAEF5974703Q38709503-9C037750-FF3B-4654-B7EC-3EFDFD563596Q38786210-48F4D6C6-4A67-4C8F-9B78-25D8E45BC3D7Q38804433-3FCB9F15-4747-4B5B-83E5-202DE4B0C9F9Q39264768-024ED940-4FDD-44E8-91D3-8463FBE458A3Q39320557-A8181A6C-3A24-451D-BACE-CC5EFF6FB43DQ39478056-C2E5960C-3636-49DE-930A-1FBAF34A21D7Q39779125-3BA1A46C-04AD-47B1-9411-89CDFF40AF31Q39937633-5371C703-7D1E-4C15-9A96-4F26CAB68ED4Q40600776-2EB6D43A-A0AE-4BDC-8D30-78A38D53C9E7Q40945233-17899648-540C-46EA-AE72-2C5DE3E6892DQ41092717-FF7B6727-5BB2-4448-8B52-675B94CA0825Q41122264-7602AC21-4839-4D4E-B609-D5036EC67206Q41252799-3C59C55C-CD4F-4A47-BF46-8BC6BB5B9059Q41844365-0E2507DD-83F5-4568-9053-B34DF2360D5BQ41894142-357592E8-1587-4C68-BFD6-D1C3800CECB1Q42427212-50FD5EB2-5BFB-4C6B-9E0C-27C7177007E7Q42427212-66FD24BE-3235-49C2-A94B-23620EEE6811Q42551323-91A842E4-0DD3-4D4C-A086-512795F05BC7Q42553719-57D0E8C8-FC7B-4C41-89EA-98BB1958D00CQ42694729-415CB03F-AFBA-43F4-9995-4655D7A4925FQ42811138-6BA50710-9C60-4AF8-8CB5-7A41BA97D28FQ42817389-B4AEE1A7-7A72-494F-B8FC-94FBA0021DBAQ42918783-46BE58D5-DE9C-4B43-86C4-F775C36E5005Q43098891-F3618A57-7E86-4B81-B840-EB00E00B217E
P921
description
group of cis/trans isomers
@en
groupe de composés cis/trans
@fr
name
geranylgeraniol
@en
type
label
geranylgeraniol
@en
prefLabel
geranylgeraniol
@en
P661
P662
P683
P1579
P2067
P231
P233
CC(=CCCC(=CCCC(=CCCC(=CCO)C)C)C)C
P234
1S/C20H34O/c1-17(2)9-6-10-18(3 ...... 15,21H,6-8,10,12,14,16H2,1-5H3
P235
OJISWRZIEWCUBN-UHFFFAOYSA-N