about
Borrelidin, a small molecule nitrile-containing macrolide inhibitor of threonyl-tRNA synthetase, is a potent inducer of apoptosis in acute lymphoblastic leukemia.Streptomyces heilongjiangensis sp. nov., a novel actinomycete that produces borrelidin isolated from the root surface of soybean [Glycine max (L.) Merr].Borrelidin modulates the alternative splicing of VEGF in favour of anti-angiogenic isoformsInsights into the preclinical treatment of blood-stage malaria by the antibiotic borrelidin.Genetic validation of aminoacyl-tRNA synthetases as drug targets in Trypanosoma brucei.Phytotoxins produced by plant pathogenic Streptomyces species.Synthesis of complex intermediates for the study of a dehydratase from borrelidin biosynthesis.Borrelidin has limited anti-cancer effects in bcl-2 overexpressing breast cancer and leukemia cells and reveals toxicity in non-malignant breast epithelial cells.Borrelidin, a potent antimalarial: stage-specific inhibition profile of synchronized cultures of Plasmodium falciparum.Eliciting antibiotics active against the ESKAPE pathogens in a collection of actinomycetes isolated from mountain soils.Borrelidin, a potent antifungal agent: insight into the antifungal mechanism against Phytophthora sojae.Stereoselectivity of Isolated Dehydratase Domains of the Borrelidin Polyketide Synthase: Implications for cis Double Bond FormationNew Metabolites From the Co-culture of Marine-Derived Actinomycete MB037 and Fungus 35Identity of borrelidin with treponemycinAntifungal activity of borrelidin produced by a Streptomyces strain isolated from soybeanIsolation of borrelidin as a phytotoxic compound from a potato pathogenic streptomyces strain
P921
Q33934165-A17B6D2C-B9DE-4BFD-85B3-E7C8BBC86A86Q34282288-7E3E803C-5520-401D-951E-E3B40EDE7992Q34347768-12AEA97C-DD8F-4D04-89E4-338761145517Q36929459-B962DE2A-CB92-4CD5-A698-E9DCC8B3BAA2Q37723989-24448C48-3015-40FD-BACE-5034BDDBAF1EQ38153148-A333D3EC-5460-49EB-8B28-BAF0AA64F8CCQ38967585-10F589F9-C6E9-4379-BFAC-9B0F70679983Q39071884-7BC55035-0F7E-4B1C-8773-12BE10203F4BQ39095907-DBBFF274-6988-4864-911A-07B1F8F55AC2Q42216691-98C3D753-618A-43A3-BBDF-869F83276764Q42715959-9EEF94DA-3C49-4F3F-A39E-046B13A917E4Q60301795-B4689323-278D-4B1F-9930-33DA3B08BA1EQ64248613-B9B3E19F-675A-4171-9687-4055B19F5075Q69447492-92477F6B-0A9C-4A88-82E9-362646906156Q83227529-7A8B8E7F-6B68-4FE9-97A0-B9B88B5FDE74Q83398877-0FC97C6E-BE6D-41E1-9656-7A5B1F7CCEAA
P921
description
chemesch Verbindung
@lb
chemical compound
@en
chemical compound
@en-ca
chemical compound
@en-gb
chemická sloučenina
@cs
chemická zlúčenina
@sk
chemiese verbinding
@af
chemische Verbindung
@de
chemische Verbindung
@de-ch
chemische verbinding
@nl
name
borrelidin
@en
type
label
borrelidin
@en
altLabel
Treponemycin
@en
prefLabel
borrelidin
@en
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C[C@H]1C[C@H](C[C@@H]([C@H](/C ...... @H]2CCC[C@H]2C(=O)O)/C#N)O)C)C
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CC1CC(CC(C(C(=CC=CCC(OC(=O)CC(C(C1)C)O)C2CCCC2C(=O)O)C#N)O)C)C
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1S/C28H43NO6/c1-17-12-18(2)14- ...... ,20-,22+,23+,24-,25+,27+/m0/s1
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OJCKRNPLOZHAOU-JTHVHBRGSA-N
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100.242.694