Intraneuronal Aβ accumulation induces hippocampal neuron hyperexcitability through A-type K(+) current inhibition mediated by activation of caspases and GSK-3.

Intraneuronal Aβ accumulation induces hippocampal neuron hyperexcitability through A-type K(+) current inhibition mediated by activation of caspases and GSK-3.

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http://www.wikidata.org/entity/Q27307787
Interictal spikes during sleep are an early defect in the Tg2576 mouse model of β-amyloid neuropathologyNorovirus P particle-based active Aβ immunotherapy elicits sufficient immunogenicity and improves cognitive capacity in a mouse model of Alzheimer's disease.CK2 activity is required for the interaction of FGF14 with voltage-gated sodium channels and neuronal excitabilityThe ability of apolipoprotein E fragments to promote intraneuronal accumulation of amyloid beta peptide 42 is both isoform and size-specific.Early-Onset Network Hyperexcitability in Presymptomatic Alzheimer's Disease Transgenic Mice Is Suppressed by Passive Immunization with Anti-Human APP/Aβ Antibody and by mGluR5 Blockade.Direct High Affinity Interaction between Aβ42 and GSK3α Stimulates Hyperphosphorylation of Tau. A New Molecular Link in Alzheimer's Disease?PPARgamma agonists rescue increased phosphorylation of FGF14 at S226 in the Tg2576 mouse model of Alzheimer's disease.Altered intrinsic excitability of hippocampal CA1 pyramidal neurons in aged PDAPP mice.LTP and memory impairment caused by extracellular Aβ and Tau oligomers is APP-dependent.Spatial Memory Impairment is Associated with Intraneural Amyloid-β Immunoreactivity and Dysfunctional Arc Expression in the Hippocampal-CA3 Region of a Transgenic Mouse Model of Alzheimer's Disease.Brain insulin resistance impairs hippocampal synaptic plasticity and memory by increasing GluA1 palmitoylation through FoxO3a.Resveratrol Attenuates Aβ-Induced Early Hippocampal Neuron Excitability Impairment via Recovery of Function of Potassium Channels.Endoplasmic reticulum stress induces spatial memory deficits by activating GSK-3.Behavioral and SCN neurophysiological disruption in the Tg-SwDI mouse model of Alzheimer's disease.Modifying Rap1-signalling by targeting Pde6δ is neuroprotective in models of Alzheimer's disease
P2860

Intraneuronal Aβ accumulation induces hippocampal neuron hyperexcitability through A-type K(+) current inhibition mediated by activation of caspases and GSK-3.

Item
http://www.wikidata.org/entity/Q27307787
description
2014 nî lūn-bûn
@nan
2014 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2014 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
2014年の論文
@ja
2014年論文
@yue
2014年論文
@zh-hant
2014年論文
@zh-hk
2014年論文
@zh-mo
2014年論文
@zh-tw
2014年论文
@wuu
name
Intraneuronal Aβ accumulation ...... tivation of caspases and GSK-3
@nl
Intraneuronal Aβ accumulation ...... ivation of caspases and GSK-3.
@ast
Intraneuronal Aβ accumulation ...... ivation of caspases and GSK-3.
@en
type
label
Intraneuronal Aβ accumulation ...... tivation of caspases and GSK-3
@nl
Intraneuronal Aβ accumulation ...... ivation of caspases and GSK-3.
@ast
Intraneuronal Aβ accumulation ...... ivation of caspases and GSK-3.
@en
prefLabel
Intraneuronal Aβ accumulation ...... tivation of caspases and GSK-3
@nl
Intraneuronal Aβ accumulation ...... ivation of caspases and GSK-3.
@ast
Intraneuronal Aβ accumulation ...... ivation of caspases and GSK-3.
@en
P1433
P1476
P2093
P2860
P304
P31
P3181
P356
P407
P433
P478
P50
P577
P5875
P698
P932
P3181
P356
P1433
P1476
Intraneuronal Aβ accumulation ...... ivation of caspases and GSK-3.
@en
P2093
P2860
P304
P31
P3181
P356
10.1016/J.NEUROBIOLAGING.2014.10.034
P407
P433
P478
P50
P577
P5875
P698
P932