Rapamycin attenuates the development of posttraumatic epilepsy in a mouse model of traumatic brain injury
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The neurology of mTOREpilepsy related to traumatic brain injury.Inflammatory mechanisms contribute to the neurological manifestations of tuberous sclerosis complex.Chronic Posttraumatic Epilepsy following Neocortical Undercut Lesion in MiceThe potential of antiseizure drugs and agents that act on novel molecular targets as antiepileptogenic treatments.Blockade of excitatory synaptogenesis with proximal dendrites of dentate granule cells following rapamycin treatment in a mouse model of temporal lobe epilepsy.Genetic activation of mTORC1 signaling worsens neurocognitive outcome after traumatic brain injury.Surviving mossy cells enlarge and receive more excitatory synaptic input in a mouse model of temporal lobe epilepsy.Transition from Initial Hypoactivity to Hyperactivity in Cortical Layer V Pyramidal Neurons after Traumatic Brain Injury In Vivo.Impact of rapamycin on status epilepticus induced hippocampal pathology and weight gain.Neuroprotective levels of IGF-1 exacerbate epileptogenesis after brain injury.A Drosophila model of closed head traumatic brain injury.mTOR Inhibition: From Aging to Autism and Beyond.Differentiation of human adipose-derived stem cells into neuron-like cells which are compatible with photocurable three-dimensional scaffolds.Past and present definitions of epileptogenesis and its biomarkers.Effects of JAK2-STAT3 signaling after cerebral insults.mTOR inhibition in epilepsy: rationale and clinical perspectives.Function and Mechanisms of Autophagy in Brain and Spinal Cord Trauma.Disease modification in epilepsy: from animal models to clinical applications.Epileptogenesis.Enhanced Dentate Neurogenesis after Brain Injury Undermines Long-Term Neurogenic Potential and Promotes Seizure Susceptibility.Tuberous sclerosis complex as a model disease for developing new therapeutics for epilepsy.WONOEP appraisal: Biomarkers of epilepsy-associated comorbidities.ER stress and impaired autophagy flux in neuronal degeneration and brain injury.Neuroprotective effects of intrastriatal injection of rapamycin in a mouse model of excitotoxicity induced by quinolinic acid.Analysis of Post-Traumatic Brain Injury Gene Expression Signature Reveals Tubulins, Nfe2l2, Nfkb, Cd44, and S100a4 as Treatment Targets.Stopping epileptogenesis dead in its trks.Deletion of mTOR in Reactive Astrocytes Suppresses Chronic Seizures in a Mouse Model of Temporal Lobe Epilepsy.TIMP3 Attenuates the Loss of Neural Stem Cells, Mature Neurons and Neurocognitive Dysfunction in Traumatic Brain Injury.Differential effects of rapamycin treatment on tonic and phasic GABAergic inhibition in dentate granule cells after focal brain injury in mice.Activation of mTOR signaling pathway is secondary to neuronal excitability in a mouse model of mesio-temporal lobe epilepsy.How and Why Study Posttraumatic Epileptogenesis in Animal Models?Effects of Rapamycin Treatment on Neurogenesis and Synaptic Reorganization in the Dentate Gyrus after Controlled Cortical Impact Injury in Mice.Prophylaxis for post-traumatic epilepsy: can your kinase do that?mTOR Strikes Again: mTORC1 Activation Causes Epilepsy Independent of Overt Pathological ChangesResveratrol improves neuron protection and functional recovery through enhancement of autophagy after spinal cord injury in mice.Seizure frequency correlates with loss of dentate gyrus GABAergic neurons in a mouse model of temporal lobe epilepsy.Long-term treatment of epilepsy with everolimus in tuberous sclerosis.Everolimus treatment of refractory epilepsy in tuberous sclerosis complex.Brain Injury-Induced Synaptic Reorganization in Hilar Inhibitory Neurons Is Differentially Suppressed by Rapamycin.
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P2860
Rapamycin attenuates the development of posttraumatic epilepsy in a mouse model of traumatic brain injury
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2013 nî lūn-bûn
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2013 թուականին հրատարակուած գիտական յօդուած
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2013 թվականին հրատարակված գիտական հոդված
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2013年の論文
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2013年学术文章
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2013年学术文章
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2013年学术文章
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2013年学术文章
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name
Rapamycin attenuates the devel ...... odel of traumatic brain injury
@ast
Rapamycin attenuates the devel ...... odel of traumatic brain injury
@en
Rapamycin attenuates the devel ...... odel of traumatic brain injury
@nl
type
label
Rapamycin attenuates the devel ...... odel of traumatic brain injury
@ast
Rapamycin attenuates the devel ...... odel of traumatic brain injury
@en
Rapamycin attenuates the devel ...... odel of traumatic brain injury
@nl
prefLabel
Rapamycin attenuates the devel ...... odel of traumatic brain injury
@ast
Rapamycin attenuates the devel ...... odel of traumatic brain injury
@en
Rapamycin attenuates the devel ...... odel of traumatic brain injury
@nl
P2093
P2860
P3181
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Rapamycin attenuates the devel ...... odel of traumatic brain injury
@en
P2093
David L Brody
Dongjun Guo
Linghui Zeng
Michael Wong
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P304
P3181
P356
10.1371/JOURNAL.PONE.0064078
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P577
2013-01-01T00:00:00Z