CD8+ T cells cause disability and axon loss in a mouse model of multiple sclerosis
about
The PPAR alpha agonist gemfibrozil is an ineffective treatment for spinal cord injured mice.Axonopathy is associated with complex axonal transport defects in a model of multiple sclerosis.Contrasting roles for CD4 vs. CD8 T-cells in a murine model of virally induced "T1 black hole" formation.Nonequivalence of classical MHC class I loci in ability to direct effective antiviral immunity.Periventricular demyelination and axonal pathology is associated with subependymal virus spread in a murine model for multiple sclerosis.Neuroinflammation by cytotoxic T-lymphocytes impairs retrograde axonal transport in an oligodendrocyte mutant mouseTransgenic expression of viral capsid proteins predisposes to axonal injury in a murine model of multiple sclerosisAn elite controller of picornavirus infection targets an epitope that is resistant to immune escapeT cell deficiency in spinal cord injury: altered locomotor recovery and whole-genome transcriptional analysis.Deletion of beta-2-microglobulin ameliorates spinal cord lesion load and promotes recovery of brainstem NAA levels in a murine model of multiple sclerosisEnhanced CD8 T-cell anti-viral function and clinical disease in B7-H1-deficient mice requires CD4 T cells during encephalomyelitis.Dimethyl fumarate may still have a role in progressive multiple sclerosis.Neuroprotective intervention by interferon-γ blockade prevents CD8+ T cell-mediated dendrite and synapse loss.Axons are injured by antigen-specific CD8(+) T cells through a MHC class I- and granzyme B-dependent mechanism.The neurotrophic hepatocyte growth factor attenuates CD8+ cytotoxic T-lymphocyte activityAxonal degeneration in multiple sclerosis: defining therapeutic targets by identifying the causes of pathology.Temporal kinetics of CD8+ CD28+ and CD8+ CD28- T lymphocytes in the injured rat spinal cord.Correlation of Brain Atrophy, Disability, and Spinal Cord Atrophy in a Murine Model of Multiple Sclerosis.Neuregulin-1 elicits a regulatory immune response following traumatic spinal cord injury.
P2860
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P2860
CD8+ T cells cause disability and axon loss in a mouse model of multiple sclerosis
description
2010 nî lūn-bûn
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2010 թուականին հրատարակուած գիտական յօդուած
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2010 թվականին հրատարակված գիտական հոդված
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2010年の論文
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2010年論文
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2010年論文
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2010年論文
@zh-hk
2010年論文
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2010年論文
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2010年论文
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name
CD8+ T cells cause disability and axon loss in a mouse model of multiple sclerosis
@ast
CD8+ T cells cause disability and axon loss in a mouse model of multiple sclerosis
@en
CD8+ T cells cause disability and axon loss in a mouse model of multiple sclerosis
@nl
type
label
CD8+ T cells cause disability and axon loss in a mouse model of multiple sclerosis
@ast
CD8+ T cells cause disability and axon loss in a mouse model of multiple sclerosis
@en
CD8+ T cells cause disability and axon loss in a mouse model of multiple sclerosis
@nl
prefLabel
CD8+ T cells cause disability and axon loss in a mouse model of multiple sclerosis
@ast
CD8+ T cells cause disability and axon loss in a mouse model of multiple sclerosis
@en
CD8+ T cells cause disability and axon loss in a mouse model of multiple sclerosis
@nl
P2093
P2860
P1433
P1476
CD8+ T cells cause disability and axon loss in a mouse model of multiple sclerosis
@en
P2093
Anthony J Windebank
Brian M Sauer
Chandra Deb
Christopher L German
Reghann G Lafrance-Corey
William F Schmalstieg
P2860
P304
P356
10.1371/JOURNAL.PONE.0012478
P407
P577
2010-01-01T00:00:00Z