A53T-alpha-synuclein overexpression impairs dopamine signaling and striatal synaptic plasticity in old mice
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Aldehyde Dehydrogenase 1 making molecular inroads into the differential vulnerability of nigrostriatal dopaminergic neuron subtypes in Parkinson's diseaseGenetically engineered mouse models of Parkinson's diseasePotentiation of neurotoxicity in double-mutant mice with Pink1 ablation and A53T-SNCA overexpression.Synucleins antagonize endoplasmic reticulum function to modulate dopamine transporter traffickingBehavioral characterization of A53T mice reveals early and late stage deficits related to Parkinson's disease.Age-dependent effects of A53T alpha-synuclein on behavior and dopaminergic functionImpaired c-Fos and polo-like kinase 2 induction in the limbic system of fear-conditioned α-synuclein transgenic miceWhat is the Clinical Significance of Cerebrospinal Fluid Biomarkers in Parkinson's disease? Is the Significance Diagnostic or Prognostic?Review: Modulation of striatal neuron activity by cyclic nucleotide signaling and phosphodiesterase inhibitionSelective binding of nuclear alpha-synuclein to the PGC1alpha promoter under conditions of oxidative stress may contribute to losses in mitochondrial function: implications for Parkinson's diseaseRGS4 is required for dopaminergic control of striatal LTD and susceptibility to parkinsonian motor deficitsAldehyde dehydrogenase 1 defines and protects a nigrostriatal dopaminergic neuron subpopulationBlood RNA biomarkers in prodromal PARK4 and rapid eye movement sleep behavior disorder show role of complexin 1 loss for risk of Parkinson's disease.Genetic mutations linked to Parkinson's disease differentially control nucleolar activity in pre-symptomatic mouse modelsProgressive neurodegeneration or endogenous compensation in an animal model of Parkinson's disease produced by decreasing doses of alpha-synuclein.Striatal dopamine transmission is subtly modified in human A53Tα-synuclein overexpressing mice.Gene expression profiles in Parkinson disease prefrontal cortex implicate FOXO1 and genes under its transcriptional regulation.Environmental neurotoxic challenge of conditional alpha-synuclein transgenic mice predicts a dopaminergic olfactory-striatal interplay in early PD.A Genetic Mouse Model of Parkinson's Disease Shows Involuntary Movements and Increased Postsynaptic Sensitivity to Apomorphine.Connectivity and circuitry in a dish versus in a brainA53T-alpha-synuclein-overexpression in the mouse nigrostriatal pathway leads to early increase of 14-3-3 epsilon and late increase of GFAPGenetic variation in the alpha synuclein gene (SNCA) is associated with BOLD response to alcohol cues.BPOZ-2 Gene Delivery Ameliorates Alpha-Synucleinopathy in A53T Transgenic Mouse Model of Parkinson's DiseaseMethyl-Arginine Profile of Brain from Aged PINK1-KO+A53T-SNCA Mice Suggests Altered Mitochondrial Biogenesis.Endocannabinoids in striatal plasticity.α-Synuclein Mutation Inhibits Endocytosis at Mammalian Central Nerve Terminals.A spontaneous deletion of α-synuclein is associated with an increase in CB1 mRNA transcript and receptor expression in the hippocampus and amygdala: effects on alcohol consumption.MicroRNA expressing profiles in A53T mutant alpha-synuclein transgenic mice and Parkinsonian.Neuromodulatory control of striatal plasticity and behavior.α-Synuclein elevation in human neurodegenerative diseases: experimental, pathogenetic, and therapeutic implications.Cystatin C as a potential therapeutic mediator against Parkinson's disease via VEGF-induced angiogenesis and enhanced neuronal autophagy in neurovascular unitsRepairing the Aged Parkinsonian Striatum: Lessons from the Lab and Clinic.Neuromelanin enhances the toxicity of α-synuclein in SK-N-SH cells.Animal models of α-synucleinopathy for Parkinson disease drug development.Age-Related Changes of 14-3-3 Isoforms in Midbrain of A53T-SNCA Overexpressing Mice.Progression of pathology in PINK1-deficient mouse brain from splicing via ubiquitination, ER stress, and mitophagy changes to neuroinflammation.The ER retention protein RER1 promotes alpha-synuclein degradation via the proteasome.Complexin-1 and Foxp1 Expression Changes Are Novel Brain Effects of Alpha-Synuclein Pathology.The PD-associated alpha-synuclein promoter Rep1 allele 2 shows diminished frequency in restless legs syndrome.Cell-Specific RNA Quantification in Human SN DA Neurons from Heterogeneous Post-mortem Midbrain Samples by UV-Laser Microdissection and RT-qPCR.
P2860
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P2860
A53T-alpha-synuclein overexpression impairs dopamine signaling and striatal synaptic plasticity in old mice
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2010 nî lūn-bûn
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2010 թուականին հրատարակուած գիտական յօդուած
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2010 թվականին հրատարակված գիտական հոդված
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2010年の論文
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2010年論文
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2010年論文
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2010年論文
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2010年論文
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2010年論文
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2010年论文
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name
A53T-alpha-synuclein overexpre ...... ynaptic plasticity in old mice
@ast
A53T-alpha-synuclein overexpre ...... ynaptic plasticity in old mice
@en
A53T-alpha-synuclein overexpre ...... ynaptic plasticity in old mice
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type
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A53T-alpha-synuclein overexpre ...... ynaptic plasticity in old mice
@ast
A53T-alpha-synuclein overexpre ...... ynaptic plasticity in old mice
@en
A53T-alpha-synuclein overexpre ...... ynaptic plasticity in old mice
@nl
prefLabel
A53T-alpha-synuclein overexpre ...... ynaptic plasticity in old mice
@ast
A53T-alpha-synuclein overexpre ...... ynaptic plasticity in old mice
@en
A53T-alpha-synuclein overexpre ...... ynaptic plasticity in old mice
@nl
P2093
P2860
P50
P921
P1433
P1476
A53T-alpha-synuclein overexpre ...... ynaptic plasticity in old mice
@en
P2093
Alexander Kurz
Georg Auburger
Hartmut Lüddens
Isabel Lastres-Becker
Javier Fernández-Ruiz
Kay L Double
Manfred Gerlach
Michael Bonin
Michela Tantucci
Paolo Calabresi
P2860
P304
P356
10.1371/JOURNAL.PONE.0011464
P407
P577
2010-01-01T00:00:00Z