Inherent dynamics of the acid-sensing ion channel 1 correlates with the gating mechanism
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Nanoscale monitoring of drug actions on cell membrane using atomic force microscopyStructure and activity of the acid-sensing ion channelsEpithelial sodium channel (ENaC) family: Phylogeny, structure-function, tissue distribution, and associated inherited diseasesASIC and ENaC type sodium channels: conformational states and the structures of the ion selectivity filtersA combined computational and functional approach identifies new residues involved in pH-dependent gating of ASIC1a.Constraint-based, homology model of the extracellular domain of the epithelial Na+ channel α subunit reveals a mechanism of channel activation by proteases.Tightening of the ATP-binding sites induces the opening of P2X receptor channelsNormal mode analysis of biomolecular structures: functional mechanisms of membrane proteins.A selectivity filter at the intracellular end of the acid-sensing ion channel pore.The contact region between three domains of the extracellular loop of ASIC1a is critical for channel function.The interaction between the first transmembrane domain and the thumb of ASIC1a is critical for its N-glycosylation and trafficking.Binding site and inhibitory mechanism of the mambalgin-2 pain-relieving peptide on acid-sensing ion channel 1a.Insights into the mechanism of pore opening of acid-sensing ion channel 1a.Atomic level characterization of the nonproton ligand-sensing domain of ASIC3 channels.Inherent dynamics of head domain correlates with ATP-recognition of P2X4 receptors: insights gained from molecular simulations.ENaC structure and function in the wake of a resolved structure of a family member.Gating mechanism of a P2X4 receptor developed from normal mode analysis and molecular dynamics simulationsHighly conserved salt bridge stabilizes rigid signal patch at extracellular loop critical for surface expression of acid-sensing ion channels.Inhibitory tract traps the epithelial Na+ channel in a low activity conformation.Ion channels in renal disease.Two di-leucine motifs regulate trafficking and function of mouse ASIC2a.Gain-of-Function Mutation W493R in the Epithelial Sodium Channel Allosterically Reconfigures Intersubunit Coupling.Neurotoxic unc-8 mutants encode constitutively active DEG/ENaC channels that are blocked by divalent cations.Insights into the molecular determinants of proton inhibition in an acid-inactivated degenerins and mammalian epithelial Na(+) channel.Protonation controls ASIC1a activity via coordinated movements in multiple domains.Emerging approaches to probing ion channel structure and function.Insight into DEG/ENaC channel gating from genetics and structure.ASICs and neuropeptides.Capturing Functional Motions of Membrane Channels and Transporters with Molecular Dynamics Simulation.Membrane anchoring and interaction between transmembrane domains are crucial for K+ channel function.Computational elucidation, Mutational and Hot spot-based designing of potential inhibitors against human acid-sensing ion channels (hASIC-1a) to treatment of various physiological conditions.The nonproton ligand of acid-sensing ion channel 3 activates mollusk-specific FaNaC channels via a mechanism independent of the native FMRFamide peptide.Mapping allosteric linkage to channel gating of extracellular domains in the human epithelial sodium channel.Human ASIC1a mediates stronger acid-induced responses as compared with mouse ASIC1a.Current perspectives on acid-sensing ion channels: new advances and therapeutic implications.Intersubunit physical couplings fostered by the left flipper domain facilitate channel opening of P2X4 receptors.Mechanism of kinase inactivation and nonbinding of FRATide to GSK3β due to K85M mutation: molecular dynamics simulation and normal mode analysis.
P2860
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P2860
Inherent dynamics of the acid-sensing ion channel 1 correlates with the gating mechanism
description
2009 nî lūn-bûn
@nan
2009 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
name
Inherent dynamics of the acid-sensing ion channel 1 correlates with the gating mechanism
@ast
Inherent dynamics of the acid-sensing ion channel 1 correlates with the gating mechanism
@en
Inherent dynamics of the acid-sensing ion channel 1 correlates with the gating mechanism
@nl
type
label
Inherent dynamics of the acid-sensing ion channel 1 correlates with the gating mechanism
@ast
Inherent dynamics of the acid-sensing ion channel 1 correlates with the gating mechanism
@en
Inherent dynamics of the acid-sensing ion channel 1 correlates with the gating mechanism
@nl
prefLabel
Inherent dynamics of the acid-sensing ion channel 1 correlates with the gating mechanism
@ast
Inherent dynamics of the acid-sensing ion channel 1 correlates with the gating mechanism
@en
Inherent dynamics of the acid-sensing ion channel 1 correlates with the gating mechanism
@nl
P2093
P2860
P1433
P1476
Inherent dynamics of the acid-sensing ion channel 1 correlates with the gating mechanism
@en
P2093
P2860
P304
P356
10.1371/JOURNAL.PBIO.1000151
P407
P50
P577
2009-07-14T00:00:00Z