Rapamycin improves TIE2-mutated venous malformation in murine model and human subjects - Wikidata - awgldk - TriplyDB

Rapamycin improves TIE2-mutated venous malformation in murine model and human subjects

Rapamycin improves TIE2-mutated venous malformation in murine model and human subjects

http://www.wikidata.org/entity/Q27333126

about

Angiopoietin-Tie signalling in the cardiovascular and lymphatic systems Somatic Activating PIK3CA Mutations Cause Venous Malformation Common and specific effects of TIE2 mutations causing venous malformations Tie1 controls angiopoietin function in vascular remodeling and inflammation.Leveraging a Sturge-Weber Gene Discovery: An Agenda for Future Research.Phosphoinositide 3-kinase: a new kid on the block in vascular anomalies.Localised intravascular coagulation complicating venous malformations in children: Associations and therapeutic options.Somatic PIK3CA mutations as a driver of sporadic venous malformations.Opposing actions of angiopoietin-2 on Tie2 signaling and FOXO1 activation Angiopoietin receptor Tie2 is required for vein specification and maintenance via regulating COUP-TFII Therapeutic targeting of the angiopoietin-TIE pathway.Somatic activating mutations in Pik3ca cause sporadic venous malformations in mice and humans.Embryonic Stem Cell-Like Subpopulations in Venous Malformation Fibroadipose vascular anomaly treated with sirolimus: Successful outcome in two patients.Advances in the Medical Management of Vascular Anomalies.Vascular Anomalies Caused by Abnormal Signaling within Endothelial Cells: Targets for Novel Therapies.[Rapamycin opens the era of targeted molecular therapy of venous malformations].Combined mTOR and MEK inhibition is an effective therapy in a novel mouse model for angiosarcoma.Sirolimus is efficacious in treatment for extensive and/or complex slow-flow vascular malformations: a monocentric prospective phase II study

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P2860

Rapamycin improves TIE2-mutated venous malformation in murine model and human subjects

http://www.wikidata.org/entity/Q27333126

description

2015 nî lūn-bûn

@nan

2015 թուականի Օգոստոսին հրատարակուած գիտական յօդուած

@hyw

2015 թվականի օգոստոսին հրատարակված գիտական հոդված

@hy

2015年の論文

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2015年論文

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2015年論文

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2015年論文

@zh-hk

2015年論文

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2015年論文

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2015年论文

@wuu

name

Rapamycin improves TIE2-mutated venous malformation in murine model and human subjects

@ast

Rapamycin improves TIE2-mutated venous malformation in murine model and human subjects

@en

Rapamycin improves TIE2-mutated venous malformation in murine model and human subjects

@nl

type

label

Rapamycin improves TIE2-mutated venous malformation in murine model and human subjects

@ast

Rapamycin improves TIE2-mutated venous malformation in murine model and human subjects

@en

Rapamycin improves TIE2-mutated venous malformation in murine model and human subjects

@nl

prefLabel

Rapamycin improves TIE2-mutated venous malformation in murine model and human subjects

@ast

Rapamycin improves TIE2-mutated venous malformation in murine model and human subjects

@en

Rapamycin improves TIE2-mutated venous malformation in murine model and human subjects

@nl

P1433

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Journal of Clinical Investigation

P1476

Rapamycin improves TIE2-mutated venous malformation in murine model and human subjects

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P2093

Antonella Mendola

http://www.w3.org/2001/XMLSchema#string

Carlo Brugnara

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Catherine Legrand

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Jennifer Hammer

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Julie Soblet

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Kyu-Tae Kang

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Lan Huang

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Laurence M Boon

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Lauri Eklund

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Marjut Natynki

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P2860

Isolation of angiopoietin-1, a ligand for the TIE2 receptor, by secretion-trap expression cloning

Vascular dysmorphogenesis caused by an activating mutation in the receptor tyrosine kinase TIE2

Angiopoietin-1 is essential in mouse vasculature during development and in response to injury.

mTOR signaling in growth control and disease

Structure of the Tie2 RTK domain: self-inhibition by the nucleotide binding loop, activation loop, and C-terminal tail

Allelic and locus heterogeneity in inherited venous malformations

Venous malformations of skeletal muscle

Targets for cell cycle arrest by the immunosuppressant rapamycin in yeast

Angiopoietin signaling in the vasculature

Requisite role of angiopoietin-1, a ligand for the TIE2 receptor, during embryonic angiogenesis

P304

3491-3504

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scholarly article

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10.1172/JCI76004

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9

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125

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Emmanuel Seront

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2015-08-10T00:00:00Z

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26258417

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human subject research

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4588237

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