Chronic intranasal treatment with an anti-Aβ(30-42) scFv antibody ameliorates amyloid pathology in a transgenic mouse model of Alzheimer's disease
about
Amyloid-β peptide-specific DARPins as a novel class of potential therapeutics for Alzheimer diseaseCombined effects of scanning ultrasound and a tau-specific single chain antibody in a tau transgenic mouse model.Altered processing of amyloid precursor protein in cells undergoing apoptosis.Characterization of a single-chain variable fragment recognizing a linear epitope of aβ: a biotechnical tool for studies on Alzheimer's disease?Intravenous immunglobulin binds beta amyloid and modifies its aggregation, neurotoxicity and microglial phagocytosis in vitro.Tau aggregation and its interplay with amyloid-β.Amyloid β oligomers in Alzheimer's disease pathogenesis, treatment, and diagnosis.Functional Characteristics and Molecular Mechanism of a New scFv Antibody Against Aβ42 Oligomers and Immature Protofibrils.Single chain variable fragment against aβ expressed in baculovirus inhibits abeta fibril elongation and promotes its disaggregation.A Peephole into the Brain: Neuropathological Features of Alzheimer's Disease Revealed by in vivo Two-Photon ImagingHigh-affinity Anticalins with aggregation-blocking activity directed against the Alzheimer β-amyloid peptide.Brain Uptake of Neurotherapeutics after Intranasal versus Intraperitoneal Delivery in Mice.Anti-Aβ single-chain variable fragment antibodies exert synergistic neuroprotective activities in Drosophila models of Alzheimer's diseaseScreening for a single-chain variable-fragment antibody that can effectively neutralize the cytotoxicity of the Vibrio parahaemolyticus thermolabile hemolysin.Oral delivery of Lactococcus lactis that secretes bioactive heme oxygenase-1 alleviates development of acute colitis in miceSynapse-binding subpopulations of Aβ oligomers sensitive to peptide assembly blockers and scFv antibodiesBrain transit and ameliorative effects of intranasally delivered anti-amyloid-β oligomer antibody in 5XFAD mice.Engineering production of functional scFv antibody in E. coli by co-expressing the molecule chaperone Skp.Loss of deep cerebellar nuclei neurons in the 3xTg-AD mice and protection by an anti-amyloid β antibody fragment.Early intervention in the 3xTg-AD mice with an amyloid β-antibody fragment ameliorates first hallmarks of Alzheimer disease.3, 4-dihydroxyl-phenyl lactic acid restores NADH dehydrogenase 1 α subunit 10 to ameliorate cardiac reperfusion injury.Solanezumab for the treatment of mild-to-moderate Alzheimer's disease.Immunotherapy for Alzheimer's disease: from anti-β-amyloid to tau-based immunization strategies.Intranasal therapeutic strategies for management of Alzheimer's disease.Harnessing the immune system for treatment and detection of tau pathology.Immunotherapies in Alzheimer's disease: Too much, too little, too late or off-target?Recombinant Antibody Fragments for Neurodegenerative Diseases.A subcutaneous cellular implant for passive immunization against amyloid-β reduces brain amyloid and tau pathologies.Lessons from Anti-Amyloid-β Immunotherapies in Alzheimer Disease: Aiming at a Moving Target.An evaluation of the capability of a biolayer interferometry biosensor to detect low-molecular-weight food contaminants.Amyloid-β fibril disruption by C60-molecular guidance for rational drug design.In Vivo Applications of Single Chain Fv (Variable Domain) (scFv) FragmentsAmyloid-related imaging abnormalities associated with immunotherapy in Alzheimer’s disease patients
P2860
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P2860
Chronic intranasal treatment with an anti-Aβ(30-42) scFv antibody ameliorates amyloid pathology in a transgenic mouse model of Alzheimer's disease
description
2011 nî lūn-bûn
@nan
2011 թուականին հրատարակուած գիտական յօդուած
@hyw
2011 թվականին հրատարակված գիտական հոդված
@hy
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
name
Chronic intranasal treatment w ...... e model of Alzheimer's disease
@ast
Chronic intranasal treatment w ...... e model of Alzheimer's disease
@en
Chronic intranasal treatment w ...... e model of Alzheimer's disease
@nl
type
label
Chronic intranasal treatment w ...... e model of Alzheimer's disease
@ast
Chronic intranasal treatment w ...... e model of Alzheimer's disease
@en
Chronic intranasal treatment w ...... e model of Alzheimer's disease
@nl
prefLabel
Chronic intranasal treatment w ...... e model of Alzheimer's disease
@ast
Chronic intranasal treatment w ...... e model of Alzheimer's disease
@en
Chronic intranasal treatment w ...... e model of Alzheimer's disease
@nl
P2093
P2860
P921
P3181
P1433
P1476
Chronic intranasal treatment w ...... e model of Alzheimer's disease
@en
P2093
Luka Kulic
Michael Hanenberg
Roger M Nitsch
Susann Cattepoel
P2860
P304
P3181
P356
10.1371/JOURNAL.PONE.0018296
P407
P577
2011-01-01T00:00:00Z