High affinity antigen recognition of the dual specific variants of herceptin is entropy-driven in spite of structural plasticity
about
Identification of sequences common to more than one therapeutic target to treat complex diseases: simulating the high variance in sequence interactivity evolved to modulate robust phenotypesCarbohydrate-mimetic peptides for pan anti-tumor responsesStructure of a human IgA1 Fab fragment at 1.55 Å resolution: potential effect of the constant domains on antigen-affinity modulationStudy of the interaction of trastuzumab and SKOV3 epithelial cancer cells using a quartz crystal microbalance sensor.A novel glycoengineered bispecific antibody format for targeted inhibition of epidermal growth factor receptor (EGFR) and insulin-like growth factor receptor type I (IGF-1R) demonstrating unique molecular properties.Could Bat Cell Temperature and Filovirus Filament Length Explain the Emergence of Ebola Virus in Mammals? Predictions of a Thermodynamic Model.A two-in-one antibody engineered from a humanized interleukin 4 antibody through mutation in heavy chain complementarity-determining regions.Comprehensive mapping of functional epitopes on dengue virus glycoprotein E DIII for binding to broadly neutralizing antibodies 4E11 and 4E5A by phage display.IBC's 22nd Annual Antibody Engineering and 9th Annual Antibody Therapeutics International Conferences and the 2011 Annual Meeting of The Antibody Society, December 5-8, 2011, San Diego, CA.Synthetic human monoclonal antibodies toward staphylococcal enterotoxin B (SEB) protective against toxic shock syndromeEvaluation of a 3-hydroxypyridin-2-one (2,3-HOPO) Based Macrocyclic Chelator for (89)Zr(4+) and Its Use for ImmunoPET Imaging of HER2 Positive Model of Ovarian Carcinoma in Mice.Cellular glycosylation affects Herceptin binding and sensitivity of breast cancer cells to doxorubicin and growth factors.Smarter drugs: a focus on pan-specific monoclonal antibodies.Progress in overcoming the chain association issue in bispecific heterodimeric IgG antibodies.Multiscale Modeling of Antibody-Drug Conjugates: Connecting Tissue and Cellular Distribution to Whole Animal Pharmacokinetics and Potential Implications for Efficacy.Directed evolution of anti-HER2 DARPins by SNAP display reveals stability/function trade-offs in the selection processDual specificity of anti-CXCL10-CXCL9 antibodies is governed by structural mimicryDeep Sequencing-guided Design of a High Affinity Dual Specificity Antibody to Target Two Angiogenic Factors in Neovascular Age-related Macular Degeneration.Assisted Design of Antibody and Protein Therapeutics (ADAPT).Incorporating Target Shedding Into a Minimal PBPK-TMDD Model for Monoclonal Antibodies.The making of bispecific antibodiesConformational flexibility of the ErbB2 ectodomain and trastuzumab antibody complex as revealed by molecular dynamics and principal component analysis.A multispecific monoclonal antibody G2 recognizes at least three completely different epitope sequences with high affinity.
P2860
Q21146715-3F89AAC1-D049-40A2-9B43-90F569204BC0Q27023624-7EF5D2BE-D6D0-4AA5-A2CD-4B726A01EC3DQ27684234-15E370F7-2986-4105-9623-E359883E31A8Q30411761-0E2254A7-9130-439F-94A4-A11087DAA9AEQ33846405-3D35BD21-0E8F-4905-8935-92AB04EDA8CCQ34541144-EC302C8C-8971-4E89-B6FC-97AE248B4699Q35117636-B04A5127-162C-4960-BD7A-438C4734F8B5Q35764445-70C3BB6B-F69D-4CD8-9DD7-E17A40A6D2B5Q35992493-64E43AC7-0AAE-4218-86A0-D175ADBE6E27Q36126966-5CF376AA-1AA8-4E2F-9D95-9C06FAE92D6CQ36644332-A2D0BAA5-7892-4162-B8D5-C1D9200C49A8Q37657607-207A74EB-5463-43F4-A7DB-9C8692678E96Q37952285-52F9C201-401E-4CB1-A073-9577FE93E24BQ38038410-B05646CC-C84E-42B0-BDD3-44BA2F7150AEQ38765188-8B2151E2-74F3-4486-8D91-74B1D7809FC5Q38857819-076F9026-7AF2-4BD2-BA86-DA4DC84BC52BQ40353620-FB2CE6B5-8C78-45A4-9EEE-085323EC08E8Q40822573-0202EAC4-F715-46A4-9E65-C63C2651D77BQ41153657-62766670-6EBE-4A08-A1C8-2F88FDA1DE10Q41906105-9F27214A-DA23-4693-BC9D-D63ADF167D3EQ42323236-F745F1EB-6429-4447-99B2-47FDE3176065Q43900453-75C861D6-274B-47A0-9E39-C09E6C463607Q47974592-E5E61F2B-B68A-4EDB-BF22-66BF7B432470
P2860
High affinity antigen recognition of the dual specific variants of herceptin is entropy-driven in spite of structural plasticity
description
2011 nî lūn-bûn
@nan
2011 թուականին հրատարակուած գիտական յօդուած
@hyw
2011 թվականին հրատարակված գիտական հոդված
@hy
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
name
High affinity antigen recognit ...... spite of structural plasticity
@ast
High affinity antigen recognit ...... spite of structural plasticity
@en
High affinity antigen recognit ...... spite of structural plasticity
@nl
type
label
High affinity antigen recognit ...... spite of structural plasticity
@ast
High affinity antigen recognit ...... spite of structural plasticity
@en
High affinity antigen recognit ...... spite of structural plasticity
@nl
prefLabel
High affinity antigen recognit ...... spite of structural plasticity
@ast
High affinity antigen recognit ...... spite of structural plasticity
@en
High affinity antigen recognit ...... spite of structural plasticity
@nl
P2093
P2860
P1433
P1476
High affinity antigen recognit ...... spite of structural plasticity
@en
P2093
Germaine Fuh
Jenny Bostrom
Lauric Haber
Patrick Koenig
Robert F Kelley
P2860
P304
P356
10.1371/JOURNAL.PONE.0017887
P407
P577
2011-01-01T00:00:00Z