Analysis of the Evolutionary Forces in an Immunodominant CD8 Epitope in Hepatitis C Virus at a Population Level - Wikidata - awgldk - TriplyDB

Analysis of the Evolutionary Forces in an Immunodominant CD8 Epitope in Hepatitis C Virus at a Population Level

Analysis of the Evolutionary Forces in an Immunodominant CD8 Epitope in Hepatitis C Virus at a Population Level

http://www.wikidata.org/entity/Q27485493

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Simultaneously Targeting the NS3 Protease and Helicase Activities for More Effective Hepatitis C Virus Therapy Distinctive pattern of sequence polymorphism in the NS3 protein of hepatitis C virus type 1b reflects conflicting evolutionary pressures Loss of viral fitness and cross-recognition by CD8+ T cells limit HCV escape from a protective HLA-B27–restricted human immune response Fuel Specificity of the Hepatitis C Virus NS3 Helicase Hepatitis C Virus (HCV) Sequence Variation Induces an HCV-Specific T-Cell Phenotype Analogous to Spontaneous Resolution Mechanism and Specificity of a Symmetrical Benzimidazolephenylcarboxamide Helicase Inhibitor Mutational escape of CD8+ T cell epitopes: implications for prevention and therapy of persistent hepatitis virus infections The broad assessment of HCV genotypes 1 and 3 antigenic targets reveals limited cross-reactivity with implications for vaccine design Statistical linkage analysis of substitutions in patient-derived sequences of genotype 1a hepatitis C virus nonstructural protein 3 exposes targets for immunogen design Sequence-based in silico analysis of well studied hepatitis C virus epitopes and their variants in other genotypes (particularly genotype 5a) against South African human leukocyte antigen backgrounds Selection pressure from neutralizing antibodies drives sequence evolution during acute infection with hepatitis C virus.Primuline derivatives that mimic RNA to stimulate hepatitis C virus NS3 helicase-catalyzed ATP hydrolysis.Anti-hepatitis C virus T-cell immunity in the context of multiple exposures to the virus.Computational reconstruction of Bole1a, a representative synthetic hepatitis C virus subtype 1a genome.H7N9 T-cell epitopes that mimic human sequences are less immunogenic and may induce Treg-mediated tolerance.Conflicting selection pressures target the NS3 protein in hepatitis C virus genotypes 1a and 1b.Identification and analysis of inhibitors targeting the hepatitis C virus NS3 helicase HLA footprints on human immunodeficiency virus type 1 are associated with interclade polymorphisms and intraclade phylogenetic clustering Immune responses during acute and chronic infection with hepatitis C virus.Resistance mechanisms in HCV: from evolution to intervention.Hepatitis C virus--T-cell responses and viral escape mutations.Quantitative microspectroscopic imaging reveals viral and cellular RNA helicase interactions in live cells.Immunogenicity and cross-reactivity of a representative ancestral sequence in hepatitis C virus infection.Divergent adaptation of hepatitis C virus genotypes 1 and 3 to human leukocyte antigen-restricted immune pressure.Acceleration of hepatitis C virus envelope evolution in humans is consistent with progressive humoral immune selection during the transition from acute to chronic infection.The host HLA-A*02 allele is associated with the response to pegylated interferon and ribavirin in patients with chronic hepatitis C virus infection.Impact of sequence variation in a dominant HLA-A*02-restricted epitope in hepatitis C virus on priming and cross-reactivity of CD8+ T cells Relics of selection in the mycobacterial genome.Degree of cross-genotype reactivity of hepatitis C virus-specific CD8+ T cells directed against NS3.

P2860

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P2860

Analysis of the Evolutionary Forces in an Immunodominant CD8 Epitope in Hepatitis C Virus at a Population Level

http://www.wikidata.org/entity/Q27485493

description

2008 nî lūn-bûn

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2008 թուականի Ապրիլին հրատարակուած գիտական յօդուած

@hyw

2008 թվականի ապրիլին հրատարակված գիտական հոդված

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2008年の論文

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2008年学术文章

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2008年学术文章

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2008年学术文章

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2008年学术文章

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2008年学术文章

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2008年學術文章

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name

Analysis of the Evolutionary F ...... C Virus at a Population Level

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Analysis of the Evolutionary F ...... C Virus at a Population Level

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Analysis of the Evolutionary F ...... C Virus at a Population Level

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Analysis of the Evolutionary F ...... C Virus at a Population Level

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Analysis of the Evolutionary F ...... C Virus at a Population Level

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Analysis of the Evolutionary F ...... C Virus at a Population Level

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Analysis of the Evolutionary F ...... C Virus at a Population Level

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Analysis of the Evolutionary F ...... C Virus at a Population Level

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Analysis of the Evolutionary F ...... C Virus at a Population Level

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Journal of Virology

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Analysis of the Evolutionary F ...... C Virus at a Population Level

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P2093

Andrea Biezynski

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Anna Eckart

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Christoph Neumann-Haefelin

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Gagandeep S Narula

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Jing Jing Wang

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Jörg Timm

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Markus Reiser

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Michael Roggendorf

http://www.w3.org/2001/XMLSchema#string

Robert Thimme

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Sergei Viazov

http://www.w3.org/2001/XMLSchema#string

P2860

Selection, transmission, and reversion of an antigen-processing cytotoxic T-lymphocyte escape mutation in human immunodeficiency virus type 1 infection

Robust hepatitis C virus infection in vitro.

Full-breadth analysis of CD8+ T-cell responses in acute hepatitis C virus infection and early therapy.

Comprehensive Analysis of CD8+-T-Cell Responses against Hepatitis C Virus Reveals Multiple Unpredicted Specificities

Hepatitis C Virus NS3 ATPases/Helicases from Different Genotypes Exhibit Variations in Enzymatic Properties

Evidence of Viral Adaptation to HLA Class I-Restricted Immune Pressure in Chronic Hepatitis C Virus Infection

Relation between viral fitness and immune escape within the hepatitis C virus protease

The C Terminus of Hepatitis C Virus NS4A Encodes an Electrostatic Switch That Regulates NS5A Hyperphosphorylation and Viral Replication

CD8 Epitope Escape and Reversion in Acute HCV Infection

Divergent and convergent evolution after a common-source outbreak of hepatitis C virus

P304

3438-51

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P31

scholarly article

P356

10.1128/JVI.01700-07

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P433

7

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P478

82

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Oliver G. Pybus

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2008-04-01T00:00:00Z

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5635837

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18216107

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2268453

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