Synergistic Reversal of Intrahepatic HCV-Specific CD8 T Cell Exhaustion by Combined PD-1/CTLA-4 Blockade - Wikidata - awgldk - TriplyDB

Synergistic Reversal of Intrahepatic HCV-Specific CD8 T Cell Exhaustion by Combined PD-1/CTLA-4 Blockade

Synergistic Reversal of Intrahepatic HCV-Specific CD8 T Cell Exhaustion by Combined PD-1/CTLA-4 Blockade

http://www.wikidata.org/entity/Q27487939

about

Inhibiting Immune Checkpoints for the Treatment of Bladder Cancer Adaptive immunity in the liver Overcoming T cell exhaustion in infection and cancer Immune responses to HCV and other hepatitis viruses T cell responses in hepatitis C virus infection: historical overview and goals for future research Forsythoside A Inhibits BVDV Replication via TRAF2-Dependent CD28–4-1BB Signaling in Bovine PBMCs Hepatitis C virus versus innate and adaptive immune responses: a tale of coevolution and coexistence Costimulatory molecule programmed death-1 in the cytotoxic response during chronic hepatitis C Selection-driven immune escape is not a significant factor in the failure of CD4 T cell responses in persistent hepatitis C virus infection Specific CD8(+) T cell response immunotherapy for hepatocellular carcinoma and viral hepatitis T-cell exhaustion in chronic hepatitis B infection: current knowledge and clinical significance Mutational escape of CD8+ T cell epitopes: implications for prevention and therapy of persistent hepatitis virus infections Programmed Death-1 expression on Epstein Barr virus specific CD8+ T cells varies by stage of infection, epitope specificity, and T-cell receptor usage PD-1 and CTLA-4 combination blockade expands infiltrating T cells and reduces regulatory T and myeloid cells within B16 melanoma tumors Programmed Cell Death-1/Programmed Death-ligand 1 Pathway: A New Target for Sepsis HCV+ hepatocytes induce human regulatory CD4+ T cells through the production of TGF-beta Liver is able to activate naïve CD8+ T cells with dysfunctional anti-viral activity in the murine system.Coexpression of PD-1, 2B4, CD160 and KLRG1 on exhausted HCV-specific CD8+ T cells is linked to antigen recognition and T cell differentiation.Tissue-specific differences in PD-1 and PD-L1 expression during chronic viral infection: implications for CD8 T-cell exhaustion CD8(+) T-Cell Responses in Acute Hepatitis C Virus Infection.Hepatitis C virus reactivation in cancer patients in the era of targeted therapies.Protective immunity against hepatitis C: many shades of gray.Expression of inhibitory receptors and polyfunctional responses of T cells are linked to the risk of congenital transmission of T. cruzi.Application of nanotechnologies for improved immune response against infectious diseases in the developing world Dual function of the NK cell receptor 2B4 (CD244) in the regulation of HCV-specific CD8+ T cells.Features of responding T cells in cancer and chronic infection.Targeting immune co-stimulatory effects of PD-L1 and PD-L2 might represent an effective therapeutic strategy in stroke.Inhibitory phenotype of HBV-specific CD4+ T-cells is characterized by high PD-1 expression but absent coregulation of multiple inhibitory molecules T-cell exhaustion: characteristics, causes and conversion.T-cell dysfunction and inhibitory receptors in hepatitis C virus infection.Immune control and failure in HCV infection--tipping the balance.EBV-specific CD8+ T cells from asymptomatic pediatric thoracic transplant patients carrying chronic high EBV loads display contrasting features: activated phenotype and exhausted function Inhibitory receptors are expressed by Trypanosoma cruzi-specific effector T cells and in hearts of subjects with chronic Chagas disease Immunization with different viral antigens alters the pattern of T cell exhaustion and latency in herpes simplex virus type 1-infected mice.Blocking of PDL-1 interaction enhances primary and secondary CD8 T cell response to herpes simplex virus-1 infection.Tim-3 expression on PD-1+ HCV-specific human CTLs is associated with viral persistence, and its blockade restores hepatocyte-directed in vitro cytotoxicity CD160 and PD-1 co-expression on HIV-specific CD8 T cells defines a subset with advanced dysfunction.Chronic thoracic spinal cord injury impairs CD8+ T-cell function by up-regulating programmed cell death-1 expression.Natural Killer Cells in Viral Hepatitis.Clinical development of monoclonal antibody-based drugs in HIV and HCV diseases

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Synergistic Reversal of Intrahepatic HCV-Specific CD8 T Cell Exhaustion by Combined PD-1/CTLA-4 Blockade

http://www.wikidata.org/entity/Q27487939

description

2009 nî lūn-bûn

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2009 թուականի Փետրուարին հրատարակուած գիտական յօդուած

@hyw

2009 թվականի փետրվարին հրատարակված գիտական հոդված

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2009年の論文

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2009年論文

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2009年論文

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2009年論文

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2009年論文

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2009年論文

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2009年论文

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JOURNAL.PPAT.1000313

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Synergistic Reversal of Intrah ...... Combined PD-1/CTLA-4 Blockade

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Abraham Shaked

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E John Wherry

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Emma Gostick

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Gordon J Freeman

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Hyosun Cho

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Kim Olthoff

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Kyong-Mi Chang

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Mary E Valiga

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Mary Kaminski

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Nobuhiro Nakamoto

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P2860

Blockade of programmed death-1 ligands on dendritic cells enhances T cell activation and cytokine production

CTLA-4 and PD-1 receptors inhibit T-cell activation by distinct mechanisms

Phenotype, localization, and mechanism of suppression of CD4(+)CD25(+) human thymocytes

Cytotoxic T lymphocyte-associated antigen 4 plays an essential role in the function of CD25(+)CD4(+) regulatory cells that control intestinal inflammation

Strain-Specific T-Cell Suppression and Protective Immunity in Patients with Chronic Hepatitis C Virus Infection

Regulatory T cells suppress in vitro proliferation of virus-specific CD8+ T cells during persistent hepatitis C virus infection

T cells with a CD4+CD25+ regulatory phenotype suppress in vitro proliferation of virus-specific CD8+ T cells during chronic hepatitis C virus infection.

Liver-Infiltrating Lymphocytes in Chronic Human Hepatitis C Virus Infection Display an Exhausted Phenotype with High Levels of PD-1 and Low Levels of CD127 Expression

Upregulation of PD-1 Expression on Circulating and Intrahepatic Hepatitis C Virus-Specific CD8+ T Cells Associated with Reversible Immune Dysfunction

Identification and In Vitro Expansion of Functional Antigen-Specific CD25+ FoxP3+ Regulatory T Cells in Hepatitis C Virus Infection

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