Identification of a Novel Determinant for Membrane Association in Hepatitis C Virus Nonstructural Protein 4B - Wikidata - awgldk - TriplyDB

Identification of a Novel Determinant for Membrane Association in Hepatitis C Virus Nonstructural Protein 4B

Identification of a Novel Determinant for Membrane Association in Hepatitis C Virus Nonstructural Protein 4B

http://www.wikidata.org/entity/Q27488432

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Flaviviral NS4b, chameleon and jack-in-the-box roles in viral replication and pathogenesis, and a molecular target for antiviral intervention Hepatitis C virus relies on lipoproteins for its life cycle Architecture and biogenesis of plus-strand RNA virus replication factories Structures of hepatitis C virus nonstructural proteins required for replicase assembly and function Formation and function of hepatitis C virus replication complexes require residues in the carboxy-terminal domain of NS4B protein An Amphipathic -Helix at the C Terminus of Hepatitis C Virus Nonstructural Protein 4B Mediates Membrane Association Mutations in Classical Swine Fever Virus NS4B Affect Virulence in Swine NS2 Proteins of GB Virus B and Hepatitis C Virus Share Common Protease Activities and Membrane Topologies Recombinant production of the amino terminal cytoplasmic region of dengue virus non-structural protein 4A for structural studies The N-terminal region of severe acute respiratory syndrome coronavirus protein 6 induces membrane rearrangement and enhances virus replication.Influenza virus m2 ion channel protein is necessary for filamentous virion formation.Determinants for membrane association of the hepatitis C virus NS2 protease domain.Membrane interacting regions of Dengue virus NS2A protein.Amphipathic alpha-helix AH2 is a major determinant for the oligomerization of hepatitis C virus nonstructural protein 4B Aminoterminal amphipathic α-helix AH1 of hepatitis C virus nonstructural protein 4B possesses a dual role in RNA replication and virus production.Equilibrium and folding simulations of NS4B H2 in pure water and water/2,2,2-trifluoroethanol mixed solvent: examination of solvation models.Influenza virus assembly and budding.Genetic complementation of hepatitis C virus nonstructural protein functions associated with replication exhibits requirements that differ from those for virion assembly.Conserved GXXXG- and S/T-like motifs in the transmembrane domains of NS4B protein are required for hepatitis C virus replication NS4B self-interaction through conserved C-terminal elements is required for the establishment of functional hepatitis C virus replication complexes.Charged residues in hepatitis C virus NS4B are critical for multiple NS4B functions in RNA replication.Rab5 and class III phosphoinositide 3-kinase Vps34 are involved in hepatitis C virus NS4B-induced autophagy.Encoded library technology screening of hepatitis C virus NS4B yields a small-molecule compound series with in vitro replicon activity.Lipid Binding of the Amphipathic Helix Serving as Membrane Anchor of Pestivirus Glycoprotein Erns Highly efficient full-length hepatitis C virus genotype 1 (strain TN) infectious culture system.Hepatitis C virus NS4B targets lipid droplets through hydrophobic residues in the amphipathic helices Coevolution analysis of Hepatitis C virus genome to identify the structural and functional dependency network of viral proteins.Modulation of hepatitis C virus genome encapsidation by nonstructural protein 4B Post-translational modifications of hepatitis C viral proteins and their biological significance.The Future of HCV Therapy: NS4B as an Antiviral Target.Interaction networks of hepatitis C virus NS4B: implications for antiviral therapy.The molecular and structural basis of advanced antiviral therapy for hepatitis C virus infection.Interaction between the NS4B amphipathic helix, AH2, and charged lipid headgroups alters membrane morphology and AH2 oligomeric state--Implications for the Hepatitis C virus life cycle.NS5A Domain 1 and Polyprotein Cleavage Kinetics Are Critical for Induction of Double-Membrane Vesicles Associated with Hepatitis C Virus Replication.Modulation of replication efficacy of the hepatitis C virus replicon Con1 by site-directed mutagenesis of an NS4B aminoterminal basic leucine zipper.A hepatitis C virus NS4B inhibitor suppresses viral genome replication by disrupting NS4B's dimerization/multimerization as well as its interaction with NS5A.Identification of a class of HCV inhibitors directed against the nonstructural protein NS4B.PTC725, an NS4B-Targeting Compound, Inhibits a Hepatitis C Virus Genotype 3 Replicon, as Predicted by Genome Sequence Analysis and Determined Experimentally Cell-free expression, purification, and membrane reconstitution for NMR studies of the nonstructural protein 4B from hepatitis C virus.Morphological and biochemical characterization of the membranous hepatitis C virus replication compartment.

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P2860

Identification of a Novel Determinant for Membrane Association in Hepatitis C Virus Nonstructural Protein 4B

http://www.wikidata.org/entity/Q27488432

description

2009 nî lūn-bûn

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2009 թուականի Յունիսին հրատարակուած գիտական յօդուած

@hyw

2009 թվականի հունիսին հրատարակված գիտական հոդված

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2009年の論文

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2009年学术文章

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2009年学术文章

@zh-cn

2009年学术文章

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2009年学术文章

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2009年学术文章

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2009年學術文章

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name

Identification of a Novel Dete ...... Virus Nonstructural Protein 4B

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Identification of a Novel Dete ...... Virus Nonstructural Protein 4B

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Identification of a Novel Dete ...... Virus Nonstructural Protein 4B

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type

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Identification of a Novel Dete ...... Virus Nonstructural Protein 4B

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Identification of a Novel Dete ...... Virus Nonstructural Protein 4B

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Identification of a Novel Dete ...... Virus Nonstructural Protein 4B

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Identification of a Novel Dete ...... Virus Nonstructural Protein 4B

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Identification of a Novel Dete ...... Virus Nonstructural Protein 4B

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Identification of a Novel Dete ...... Virus Nonstructural Protein 4B

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Journal of Virology

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Identification of a Novel Dete ...... Virus Nonstructural Protein 4B

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P2093

Eric Diesis

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Hubert E Blum

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Jean-Marie Ruysschaert

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Naveen Arora

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Valérie Castet

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Vincent Raussens

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P2860

CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice

WT1 suppresses synthesis of the epidermal growth factor receptor and induces apoptosis

Expression of hepatitis C virus proteins induces distinct membrane alterations including a candidate viral replication complex

Isolation and characterization of noncytopathic pestivirus mutants reveals a role for nonstructural protein NS4B in viral cytopathogenicity.

Quantitative Analysis of the Hepatitis C Virus Replication Complex

Highly permissive cell lines for subgenomic and genomic hepatitis C virus RNA replication.

The hepatitis C virus RNA-dependent RNA polymerase membrane insertion sequence is a transmembrane segment.

Palmitoylation and Polymerization of Hepatitis C Virus NS4B Protein

Topology of the Membrane-Associated Hepatitis C Virus Protein NS4B

Identification of the Hepatitis C Virus RNA Replication Complex in Huh-7 Cells Harboring Subgenomic Replicons

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6257-68

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scholarly article

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1478039

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P356

10.1128/JVI.02663-08

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12

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83

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Darius Moradpour

François Penin

Roland Montserret

Jérôme Gouttenoire

Jean-Marie Ruysschaert

P577

2009-06-01T00:00:00Z

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P698

19357161

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P921

Hepatitis C virus

P932

2687391

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