about
The proprotein convertase PCSK9 induces the degradation of low density lipoprotein receptor (LDLR) and its closest family members VLDLR and ApoER2Regulation of epithelial sodium channel trafficking by proprotein convertase subtilisin/kexin type 9 (PCSK9)Annexin A2 is a C-terminal PCSK9-binding protein that regulates endogenous low density lipoprotein receptor levelsPCSK9 LNA antisense oligonucleotides induce sustained reduction of LDL cholesterol in nonhuman primatesTherapeutic RNAi targeting PCSK9 acutely lowers plasma cholesterol in rodents and LDL cholesterol in nonhuman primatesHepatocyte nuclear factor 1alpha plays a critical role in PCSK9 gene transcription and regulation by the natural hypocholesterolemic compound berberineApolipoprotein B Is an innate barrier against invasive Staphylococcus aureus infectionLipid nanoparticles for targeted siRNA delivery - going from bench to bedsideClinical efficacy and safety of evolocumab for low-density lipoprotein cholesterol reductionNew drugs for treating dyslipidemia: beyond statinsStructural and biophysical studies of PCSK9 and its mutants linked to familial hypercholesterolemiaMolecular basis for LDL receptor recognition by PCSK9Antagonism of Secreted PCSK9 Increases Low Density Lipoprotein Receptor Expression in HepG2 CellsA PCSK9-binding antibody that structurally mimics the EGF(A) domain of LDL-receptor reduces LDL cholesterol in vivoPCSK9 inhibitors in the prevention of cardiovascular diseaseNew Era of Lipid-Lowering DrugsThe closed conformation of the LDL receptor is destabilized by the low Ca(++) concentration but favored by the high Mg(++) concentration in the endosomeStructural requirements for PCSK9-mediated degradation of the low-density lipoprotein receptorEvidence for positive selection in the C-terminal domain of the cholesterol metabolism gene PCSK9 based on phylogenetic analysis in 14 primate speciesMembrane transporters and protein traffic networks differentially affecting metal tolerance: a genomic phenotyping study in yeast.PCSK9 regulates apoptosis in human lung adenocarcinoma A549 cells via endoplasmic reticulum stress and mitochondrial signaling pathways.Identification of mRNA binding proteins that regulate the stability of LDL receptor mRNA through AU-rich elements.Fenofibrate treatment increases human serum proprotein convertase subtilisin kexin type 9 levels.Molecular population genetics of PCSK9: a signature of recent positive selection.Saturation of the human phenomePCSK9 siRNA inhibits HUVEC apoptosis induced by ox-LDL via Bcl/Bax-caspase9-caspase3 pathway.Serum PCSK9 Levels Distinguish Individuals Who Do Not Respond to High-Dose Statin Therapy with the Expected Reduction in LDL-CIn vivo genome editing using Staphylococcus aureus Cas9High-dose atorvastatin causes a rapid sustained increase in human serum PCSK9 and disrupts its correlation with LDL cholesterolPlasma PCSK9 levels are elevated with acute myocardial infarction in two independent retrospective angiographic studiesEffects of PCSK9 genetic variants on plasma LDL cholesterol levels and risk of premature myocardial infarction in the Italian populationFabs enable single particle cryoEM studies of small proteinsNovel domain interaction regulates secretion of proprotein convertase subtilisin/kexin type 9 (PCSK9) protein.Alirocumab inhibits atherosclerosis, improves the plaque morphology, and enhances the effects of a statin.Therapeutic RNA manipulation in liver disease.Correlation of PCSK9 gene polymorphism with cerebral ischemic stroke in Xinjiang Han and Uygur populations.Plasma PCSK9 concentrations during an oral fat load and after short term high-fat, high-fat high-protein and high-fructose diets.Genetic association of APOB polymorphisms with variation in serum lipid profile among the Kuwait population.Effect of an RNA interference drug on the synthesis of proprotein convertase subtilisin/kexin type 9 (PCSK9) and the concentration of serum LDL cholesterol in healthy volunteers: a randomised, single-blind, placebo-controlled, phase 1 trial.PCSK9 and LDLR degradation: regulatory mechanisms in circulation and in cells.
P2860
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P2860
description
2007 nî lūn-bûn
@nan
2007 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2007 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
name
Molecular biology of PCSK9: its role in LDL metabolism
@ast
Molecular biology of PCSK9: its role in LDL metabolism
@en
Molecular biology of PCSK9: its role in LDL metabolism
@nl
type
label
Molecular biology of PCSK9: its role in LDL metabolism
@ast
Molecular biology of PCSK9: its role in LDL metabolism
@en
Molecular biology of PCSK9: its role in LDL metabolism
@nl
prefLabel
Molecular biology of PCSK9: its role in LDL metabolism
@ast
Molecular biology of PCSK9: its role in LDL metabolism
@en
Molecular biology of PCSK9: its role in LDL metabolism
@nl
P2093
P2860
P3181
P1476
Molecular biology of PCSK9: its role in LDL metabolism
@en
P2093
Helen H Hobbs
Jay D Horton
Jonathan C Cohen
P2860
P3181
P356
10.1016/J.TIBS.2006.12.008
P577
2007-02-01T00:00:00Z