Crystal structure of Trypanosoma cruzi trypanothione reductase in complex with trypanothione, and the structure-based discovery of new natural product inhibitors
about
Three-dimensional structure of a mammalian thioredoxin reductase: implications for mechanism and evolution of a selenocysteine-dependent enzymeTwo interacting binding sites for quinacrine derivatives in the active site of trypanothione reductase: a template for drug designSequence-structure analysis of FAD-containing proteinsLeishmania trypanothione synthetase-amidase structure reveals a basis for regulation of conflicting synthetic and hydrolytic activitiesMini review on tricyclic compounds as an inhibitor of trypanothione reductaseCarbon-oxygen hydrogen bonding in biological structure and functionThe high resolution crystal structure of recombinant Crithidia fasciculata tryparedoxin-IStructures of tryparedoxins revealing interaction with trypanothioneStructural and Biochemical Studies Reveal Differences in the Catalytic Mechanisms of Mammalian and Drosophila melanogaster Thioredoxin Reductases †Structural insights into the catalytic mechanism of Trypanosoma cruzi GPXI (glutathione peroxidase-like enzyme I)Structure of Trypanosoma brucei glutathione synthetase: Domain and loop alterations in the catalytic cycle of a highly conserved enzymeExploiting the high-resolution crystal structure of Staphylococcus aureus MenH to gain insight into enzyme activityInhibition of Leishmania infantum trypanothione reductase by azole-based compounds: a comparative analysis with its physiological substrate by X-ray crystallographyBinding to large enzyme pockets: small-molecule inhibitors of trypanothione reductaseThe Potential of Secondary Metabolites from Plants as Drugs or Leads against Protozoan Neglected Diseases-Part III: In-Silico Molecular Docking InvestigationsStructural analysis and molecular docking of trypanocidal aryloxy-quinones in trypanothione and glutathione reductases: a comparison with biochemical data.Bis(glutathionyl)spermine and other novel trypanothione analogues in Trypanosoma cruzi.Plasticity in the primary binding site of galactose/N-acetylgalactosamine-specific lectins. Implication of the C-H...O hydrogen bond at the specificity-determining C-4 locus of the saccharide in 4-methoxygalactose recognition by jacalin and winged bDevelopment of a novel virtual screening cascade protocol to identify potential trypanothione reductase inhibitors.Improved tricyclic inhibitors of trypanothione reductase by screening and chemical synthesis.The parasite-specific trypanothione metabolism of trypanosoma and leishmania.Crystal structures of oxidized and reduced mitochondrial thioredoxin reductase provide molecular details of the reaction mechanism.Trypanothione synthesis in crithidia revisited.The therapeutic potential of inhibitors of the trypanothione cycle.Catalytic roles for carbon-oxygen hydrogen bonding in SET domain lysine methyltransferases.Metabolic pathway analysis in trypanosomes and malaria parasitesDirect evidence for methyl group coordination by carbon-oxygen hydrogen bonds in the lysine methyltransferase SET7/9Screening and synthesis: high throughput technologies applied to parasitology.The synthesis and inhibitory activity of dethiotrypanothione and analogues against trypanothione reductaseTrypanocidal drugs: mechanisms, resistance and new targets.Indazoles: a new top seed structure in the search of efficient drugs against Trypanosoma cruzi.Molecular recognition in chemical and biological systems.The Architecture of Thiol Antioxidant Systems among Invertebrate Parasites.Receptor-dependent 4D-QSAR analysis of peptidemimetic inhibitors of Trypanosoma cruzi trypanothione reductase with receptor-based alignment.Antitrypanosomal properties of Panax ginseng C. A. Meyer: new possibilities for a remarkable traditional drug.Identification of potential trypanothione reductase inhibitors among commercially available [Formula: see text]-carboline derivatives using chemical space, lead-like and drug-like filters, pharmacophore models and molecular docking.Molecular dynamics simulations of peptide inhibitors complexed with Trypanosoma cruzi trypanothione reductase.Trypanothione reductase: a viable chemotherapeutic target for antitrypanosomal and antileishmanial drug design.Antitumor quinol PMX464 is a cytocidal anti-trypanosomal inhibitor targeting trypanothione metabolism.Ellman's-reagent-mediated regeneration of trypanothione in situ: substrate-economical microplate and time-dependent inhibition assays for trypanothione reductase.
P2860
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P2860
Crystal structure of Trypanosoma cruzi trypanothione reductase in complex with trypanothione, and the structure-based discovery of new natural product inhibitors
description
1999 nî lūn-bûn
@nan
1999 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
1999 թվականի հունվարին հրատարակված գիտական հոդված
@hy
1999年の論文
@ja
1999年論文
@yue
1999年論文
@zh-hant
1999年論文
@zh-hk
1999年論文
@zh-mo
1999年論文
@zh-tw
1999年论文
@wuu
name
Crystal structure of Trypanoso ...... new natural product inhibitors
@ast
Crystal structure of Trypanoso ...... new natural product inhibitors
@en
Crystal structure of Trypanoso ...... new natural product inhibitors
@nl
type
label
Crystal structure of Trypanoso ...... new natural product inhibitors
@ast
Crystal structure of Trypanoso ...... new natural product inhibitors
@en
Crystal structure of Trypanoso ...... new natural product inhibitors
@nl
prefLabel
Crystal structure of Trypanoso ...... new natural product inhibitors
@ast
Crystal structure of Trypanoso ...... new natural product inhibitors
@en
Crystal structure of Trypanoso ...... new natural product inhibitors
@nl
P2093
P50
P1433
P1476
Crystal structure of Trypanoso ...... new natural product inhibitors
@en
P2093
M Berriman
M L Cunningham
P356
10.1016/S0969-2126(99)80011-2
P577
1999-01-01T00:00:00Z