The aspartic proteinase from Saccharomyces cerevisiae folds its own inhibitor into a helix
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The potency and specificity of the interaction between the IA3 inhibitor and its target aspartic proteinase from Saccharomyces cerevisiaeSolution Structure of the Squash Aspartic Acid Proteinase Inhibitor (SQAPI) and Mutational Analysis of Pepsin InhibitionUnique thrombin inhibition mechanism by anophelin, an anticoagulant from the malaria vectorThe structure of the SBP-Tag-streptavidin complex reveals a novel helical scaffold bridging binding pockets on separate subunits.Comparative analysis of Saccharomyces cerevisiae WW domains and their interacting proteins.Key features determining the specificity of aspartic proteinase inhibition by the helix-forming IA3 polypeptide.Analysis of crystal structures of aspartic proteinases: on the role of amino acid residues adjacent to the catalytic site of pepsin-like enzymesN-terminal extension of the yeast IA3 aspartic proteinase inhibitor relaxes the strict intrinsic selectivity.ff14IDPs force field improving the conformation sampling of intrinsically disordered proteins.Test and Evaluation of ff99IDPs Force Field for Intrinsically Disordered Proteins.Multi-scaled explorations of binding-induced folding of intrinsically disordered protein inhibitor IA3 to its target enzyme.Recognition between flexible protein molecules: induced and assisted folding.Structured disorder and conformational selection.Continuous wave W- and D-band EPR spectroscopy offer "sweet-spots" for characterizing conformational changes and dynamics in intrinsically disordered proteins.The many faces of protease-protein inhibitor interactionGenetic and molecular aspects of Alzheimer's disease shed light on new mechanisms of transcriptional regulation.Rate constants and mechanisms of intrinsically disordered proteins binding to structured targetsProtease inhibitors as potential disease-modifying therapeutics for Alzheimer's disease.Intrinsically semi-disordered state and its role in induced folding and protein aggregationMeCP2: structure and function.Side-chain to main-chain hydrogen bonding controls the intrinsic backbone dynamics of the amyloid precursor protein transmembrane helixsAβPPα is a Potent Endogenous Inhibitor of BACE1.Characterization of the disordered-to-α-helical transition of IA₃ by SDSL-EPR spectroscopy.Heparan sulfate regulates amyloid precursor protein processing by BACE1, the Alzheimer's beta-secretase.The backbone dynamics of the amyloid precursor protein transmembrane helix provides a rationale for the sequential cleavage mechanism of γ-secretase.Analysis of binding interactions of pepsin inhibitor-3 to mammalian and malarial aspartic proteases.Predicting functional residues of the Solanum lycopersicum aspartic protease inhibitor (SLAPI) by combining sequence and structural analysis with molecular docking.Cathepsin D is specifically inhibited by deoxyribonucleic acids.Analysis of the interaction between the aspartic peptidase inhibitor SQAPI and aspartic peptidases using surface plasmon resonance.The IDP-Specific Force Field ff14IDPSFF Improves the Conformer Sampling of Intrinsically Disordered Proteins.Virtual interface substructure synthesis method for normal mode analysis of super-large molecular complexes at atomic resolution.
P2860
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P2860
The aspartic proteinase from Saccharomyces cerevisiae folds its own inhibitor into a helix
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The aspartic proteinase from S ...... its own inhibitor into a helix
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The aspartic proteinase from S ...... its own inhibitor into a helix
@en
The aspartic proteinase from S ...... its own inhibitor into a helix
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The aspartic proteinase from S ...... its own inhibitor into a helix
@ast
The aspartic proteinase from S ...... its own inhibitor into a helix
@en
The aspartic proteinase from S ...... its own inhibitor into a helix
@nl
prefLabel
The aspartic proteinase from S ...... its own inhibitor into a helix
@ast
The aspartic proteinase from S ...... its own inhibitor into a helix
@en
The aspartic proteinase from S ...... its own inhibitor into a helix
@nl
P2093
P356
P1476
The aspartic proteinase from S ...... its own inhibitor into a helix
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P2093
A Gustchina
A Wlodawer
J R Winther
L H Phylip
P356
10.1038/72378
P577
2000-02-01T00:00:00Z