Solution structure of ERK2 binding domain of MAPK phosphatase MKP-3: structural insights into MKP-3 activation by ERK2
about
MAP kinase phosphatasesCharacterization of a murine gene encoding a developmentally regulated cytoplasmic dual-specificity mitogen-activated protein kinase phosphataseExtracellular signal-regulated kinases phosphorylate mitogen-activated protein kinase phosphatase 3/DUSP6 at serines 159 and 197, two sites critical for its proteasomal degradationn-->pi* interactions in proteinsCrystal structure of the MAP kinase binding domain and the catalytic domain of human MKP5Potential tumor suppressive pathway involving DUSP6/MKP-3 in pancreatic cancerImpacts of activation of the mitogen-activated protein kinase pathway in pancreatic cancerMitogen-activated Protein Kinase (MAPK) Phosphatase 3-mediated Cross-talk between MAPKs ERK2 and p38Atypical mitogen-activated protein kinase phosphatase implicated in regulating transition from pre-S-Phase asexual intraerythrocytic development of Plasmodium falciparumIn silico characterization of an atypical MAPK phosphatase of Plasmodium falciparum as a suitable target for drug discoveryToward a molecular understanding of the interaction of dual specificity phosphatases with substrates: insights from structure-based modeling and high throughput screening.Assembly of the Sos1-Grb2-Gab1 ternary signaling complex is under allosteric controlStructure and catalytic mechanism of human protein tyrosine phosphatome.Docking sites on mitogen-activated protein kinase (MAPK) kinases, MAPK phosphatases and the Elk-1 transcription factor compete for MAPK binding and are crucial for enzymic activity.EGFR-mutated lung cancer: a paradigm of molecular oncology.The noncatalytic amino terminus of mitogen-activated protein kinase phosphatase 1 directs nuclear targeting and serum response element transcriptional regulation.Disordered binding regions and linear motifs--bridging the gap between two models of molecular recognition.Protein expression, characterization and activity comparisons of wild type and mutant DUSP5 proteinsAn ERK2 docking site in the Pointed domain distinguishes a subset of ETS transcription factors.Interaction of kinase-interaction-motif protein tyrosine phosphatases with the mitogen-activated protein kinase ERK2Expression of dual-specificity phosphatase 5 pseudogene 1 (DUSP5P1) in tumor cellsNitric oxide affects ERK signaling through down-regulation of MAP kinase phosphatase levels during larval development of the ascidian Ciona intestinalis.Identification of inhibitors that target dual-specificity phosphatase 5 provide new insights into the binding requirements for the two phosphate pocketsMKP-3 has essential roles as a negative regulator of the Ras/mitogen-activated protein kinase pathway during Drosophila development.Small-molecule inhibitors of ERK-mediated immediate early gene expression and proliferation of melanoma cells expressing mutated BRafSolution structure of the rhodanese homology domain At4g01050(175-295) from Arabidopsis thaliana.Diversity and specificity of the mitogen-activated protein kinase phosphatase-1 functions.The hepatitis E virus open reading frame 3 protein activates ERK through binding and inhibition of the MAPK phosphataseInhibition of mitogen-activated protein kinase phosphatase 3 activity by interdomain bindingStructural basis for the regulation of the mitogen-activated protein (MAP) kinase p38α by the dual specificity phosphatase 16 MAP kinase binding domain in solutionMolecular basis of MAP kinase regulation.Phenotypic Characterization of a Comprehensive Set of MAPK1/ERK2 Missense Mutants.WT1 induction of mitogen-activated protein kinase phosphatase 3 represents a novel mechanism of growth suppression.Follicle-Stimulating Hormone (FSH)-dependent Regulation of Extracellular Regulated Kinase (ERK) Phosphorylation by the Mitogen-activated Protein (MAP) Kinase Phosphatase MKP3.A semidominant mutation in an Arabidopsis mitogen-activated protein kinase phosphatase-like gene compromises cortical microtubule organization.Dual-specificity phosphatase 6 (DUSP6): a review of its molecular characteristics and clinical relevance in cancer.
P2860
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P2860
Solution structure of ERK2 binding domain of MAPK phosphatase MKP-3: structural insights into MKP-3 activation by ERK2
description
2001 nî lūn-bûn
@nan
2001 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2001 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
2001年の論文
@ja
2001年論文
@yue
2001年論文
@zh-hant
2001年論文
@zh-hk
2001年論文
@zh-mo
2001年論文
@zh-tw
2001年论文
@wuu
name
Solution structure of ERK2 bin ...... into MKP-3 activation by ERK2
@ast
Solution structure of ERK2 bin ...... into MKP-3 activation by ERK2
@en
Solution structure of ERK2 bin ...... into MKP-3 activation by ERK2
@nl
type
label
Solution structure of ERK2 bin ...... into MKP-3 activation by ERK2
@ast
Solution structure of ERK2 bin ...... into MKP-3 activation by ERK2
@en
Solution structure of ERK2 bin ...... into MKP-3 activation by ERK2
@nl
prefLabel
Solution structure of ERK2 bin ...... into MKP-3 activation by ERK2
@ast
Solution structure of ERK2 bin ...... into MKP-3 activation by ERK2
@en
Solution structure of ERK2 bin ...... into MKP-3 activation by ERK2
@nl
P2093
P1433
P1476
Solution structure of ERK2 bin ...... into MKP-3 activation by ERK2
@en
P2093
C Dhalluin
G Chaturvedi
O Plotnikova
P304
P577
2001-02-01T00:00:00Z